公开(公告)号：US20110237527A1

公开(公告)日：2011-09-29

申请号：US13052171

申请日：2011-03-21

申请人： Shuang LIU ,  Cheng GUO ,  Min HU ,  Douglas B. KITCHEN ,  Peter R. GUZZO ,  Russell DEORAZIO

发明人： Shuang LIU ,  Cheng GUO ,  Min HU ,  Douglas B. KITCHEN ,  Peter R. GUZZO ,  Russell DEORAZIO

IPC分类号： A61K31/706 ,  C07H7/06 ,  A61P3/10 ,  A61P27/12 ,  A61P3/06 ,  A61P3/04 ,  A61P17/02 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06

CPC分类号： A61K31/706

摘要： The present invention relates to compounds which are inhibitors of sodium dependent glucose co-transporter-2 (SGLT-2). These compounds are used in the treatment of various disorders, including diabetes, impaired glucose tolerance, insulin resistance, retinopathy, nephropathy, neuropathy, cataracts, hyperglycemia, hyperinsulinemia, hyperchlolesterolemia, elevated blood level of free fatty acids or glycerol, hyperlipidemia, hypertriglyceridemia, obesity, wound healing, tissue ischemia, atherosclerosis, and hypertension. These compounds and compositions are also useful for treating and preventing kidney stones, hyperuricemia, gout, and hyponatremia. Methods of making these compounds are also described in the present invention.

摘要翻译： 本发明涉及作为钠依赖性葡萄糖共转运体-2（SGLT-2）抑制剂的化合物。 这些化合物用于治疗各种疾病，包括糖尿病，葡萄糖耐量降低，胰岛素抵抗，视网膜病变，肾病，神经病，白内障，高血糖症，高胰岛素血症，高胆固醇血症，游离脂肪酸或甘油血液水平升高，高脂血症，高甘油三酯血症，肥胖 伤口愈合，组织缺血，动脉粥样硬化和高血压。 这些化合物和组合物还可用于治疗和预防肾结石，高尿酸血症，痛风和低钠血症。 制备这些化合物的方法也在本发明中描述。

公开(公告)号：US20090118260A1

公开(公告)日：2009-05-07

申请号：US12253170

申请日：2008-10-16

申请人： Bruce F. MOLINO ,  Shuang LIU ,  Aruna SAMBANDAM ,  Peter R. GUZZO ,  Min HU ,  Congxiang ZHA ,  Kassoum NACRO ,  David D. MANNING ,  Matthew L. ISHERWOOD ,  Kristen N. FLEMING ,  Wenge CUI ,  Richard E. OLSON

发明人： Bruce F. MOLINO ,  Shuang LIU ,  Aruna SAMBANDAM ,  Peter R. GUZZO ,  Min HU ,  Congxiang ZHA ,  Kassoum NACRO ,  David D. MANNING ,  Matthew L. ISHERWOOD ,  Kristen N. FLEMING ,  Wenge CUI ,  Richard E. OLSON

IPC分类号： A61K31/55 ,  C07D487/02 ,  C07D403/02

CPC分类号： C07D223/16 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.

摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。

公开(公告)号：US20110267607A1

公开(公告)日：2011-11-03

申请号：US12771753

申请日：2010-04-30

申请人： Min HU ,  Wei WU ,  Fung Suong OU ,  Zhiyong LI ,  R. Stanley WILLIAMS

发明人： Min HU ,  Wei WU ,  Fung Suong OU ,  Zhiyong LI ,  R. Stanley WILLIAMS

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  B82Y15/00

摘要： An integrated device for enhancing signals in Surface Enhanced Raman Spectroscopy (SERS). The integrated device comprising an array of nanostructures comprising a material, wherein the material is configured to allow light to pass through. The integrated device also comprising SERS active nanoparticles disposed on at least portion of the array of nanostructures and a mirror integrated below a base of the array of nanostructures. The mirror is configured to reflect light passing through the material into the array of nanostructures.

摘要翻译： 一种用于增强表面增强拉曼光谱（SERS）信号的集成器件。 所述集成器件包括纳米结构的阵列，其包括材料，其中所述材料被配置为允许光通过。 该集成装置还包括设置在纳米结构阵列的至少一部分上的SERS活性纳米颗粒和集成在纳米结构阵列的基底下方的反射镜。 镜子被配置为将通过材料的光反射到纳米结构阵列中。

公开(公告)号：US20110267610A1

公开(公告)日：2011-11-03

申请号：US12772063

申请日：2010-04-30

申请人： Min HU ,  Wei Wu ,  Fung Suong Ou ,  Zhen Peng ,  Zhiyong Li ,  R. Stanley Williams

发明人： Min HU ,  Wei Wu ,  Fung Suong Ou ,  Zhen Peng ,  Zhiyong Li ,  R. Stanley Williams

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  G01N21/7746

摘要： A compact sensor system comprising: an analysis cell configured for photon-matter interaction, where photons are received from a light source; and an integrated-optical spectral analyzer configured for identifying a set of frequencies, the integrated-optical spectral analyzer comprising: a waveguide coupled with the analysis cell, the waveguide configured for propagating a set of frequencies through the waveguide; one or more ring resonators coupled with the waveguide, the one or more ring resonators comprising a predetermined bandwidth and configured for capturing the set of frequencies corresponding to frequencies within the predetermined bandwidth; and one or more frequency detectors coupled with the one or more tunable ring resonators, the one or more frequency detectors configured for generating electrical signals that identify each of the set of frequencies.

摘要翻译： 一种紧凑的传感器系统，包括：配置用于光子 - 物质相互作用的分析单元，其中从光源接收光子; 所述集成光谱分析仪包括：与所述分析单元耦合的波导，所述波导被配置为通过所述波导传播一组频率;以及波导，其被配置为用于识别一组频率。 一个或多个与所述波导耦合的环形谐振器，所述一个或多个环形谐振器包括预定带宽并被配置用于捕获与所述预定带宽内的频率相对应的频率集合; 以及与所述一个或多个可调环形谐振器耦合的一个或多个频率检测器，所述一个或多个频率检测器被配置用于产生标识所述一组频率中的每一个的电信号。

公开(公告)号：US20150177151A1

公开(公告)日：2015-06-25

申请号：US13194556

申请日：2011-07-29

申请人： Min HU ,  Zhiyong LI ,  Fung Suong OU ,  Ansoon KIM

发明人： Min HU ,  Zhiyong LI ,  Fung Suong OU ,  Ansoon KIM

IPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/44

CPC分类号： G01N21/658 ,  B82Y20/00 ,  G01J3/0256 ,  G01J3/4412 ,  G01N2201/06113 ,  Y10S977/954 ,  Y10T29/49

摘要： In a method of fabricating an apparatus for use in a sensing application, a plurality of nano-fingers are formed on a substrate and a Raman-active material nano-particle is formed on respective tips of the nano-fingers. In addition, the Raman-active material nano-particles on the tips of adjacent ones of the nano-fingers are caused to come into contact with the Raman-active material nano-particle on the tip of at least another one of the plurality of nano-fingers to form respective clusters and the clusters of Raman-active material nano-particles are transferred to a component layer from the plurality of nano-fingers while maintaining a spatial relationship between the contacting Raman-active material nano-particles.

摘要翻译： 在制造用于感测应用的装置的方法中，在衬底上形成多个纳米指，并且在纳米手指的各个尖端上形成拉曼活性材料纳米颗粒。 另外，使相邻的纳米指尖的拉曼活性物质纳米粒子与多个纳米尺寸中的至少另一个的前端的拉曼活性物质纳米粒子接触 - 形成相应的簇，并且拉曼活性材料纳米颗粒簇从多个纳米指转移到组分层，同时保持接触拉曼活性材料纳米颗粒之间的空间关系。

公开(公告)号：US20150157775A1

公开(公告)日：2015-06-11

申请号：US14621362

申请日：2015-02-12

申请人： Min HU

发明人： Min HU

IPC分类号： A61M1/06 ,  A61F7/00

CPC分类号： A61M1/062 ,  A61F7/007 ,  A61F2007/0021 ,  A61F2007/0088 ,  A61M1/064 ,  A61M2205/3633 ,  A61M2205/3653 ,  A61M2205/8206

摘要： A breast pump including a container, a host unit disposed above and communicating with the container, an electric heating cup disposed at the front end of the host unit and communicating with the container, an electric heating element, and heat insulation. The electric heating cup includes an inner cover and an outer cover which are integrated. The electric heating element and the heat insulation are disposed between the inner cover and the outer cover. The heat insulation is disposed between the electric heating element and the outer cover. Positive and negative electrodes of the electric heating element are connected to conducting plates disposed in the inner side of the outer cover via connection wires. The conducting plates extend to the outer side of the outer cover and are in electric connection to contact chips disposed at the lower front end of the host unit.

摘要翻译： 一种吸奶器，包括容器，设置在容器上方并与容器连通的主体单元，设置在主体单元的前端并与容器连通的电加热杯，电加热元件和隔热层。 电加热杯包括一体的内盖和外盖。 电加热元件和隔热件设置在内盖和外盖之间。 隔热件设置在电加热元件和外盖之间。 电加热元件的正极和负极通过连接线连接到设置在外盖的内侧的导电板。 导电板延伸到外盖的外侧并且与设置在主机单元的下前端的接触芯片电连接。

公开(公告)号：US20110073487A1

公开(公告)日：2011-03-31

申请号：US12570227

申请日：2009-09-30

申请人： Ran Niu ,  Hai Yang ,  John H. Barber ,  Min HU ,  Rihua Xiong ,  Wei Cai ,  Xin Gao ,  Yunfeng Liu

发明人： Ran Niu ,  Hai Yang ,  John H. Barber ,  Min HU ,  Rihua Xiong ,  Wei Cai ,  Xin Gao ,  Yunfeng Liu

IPC分类号： B01D57/00

CPC分类号： C02F1/4691 ,  C02F2103/08 ,  C02F2201/46135 ,  C02F2201/4614 ,  C02F2209/005

摘要： An electrochemical desalination system includes a first and a second electrochemical device and a controller. The first and second electrochemical devices each comprises a electrochemical desalination module comprising at least one pair of electrodes and a compartment between each pair of electrodes for receiving an electrolyte solution. Each of the first and second electrochemical desalination devices comprises a plurality of successive operation cycles. Each cycle comprises a charging mode of operation for charging each pair of electrodes and for adsorbing ions in the electrolyte solution on the electrodes, and a discharging mode of operation for discharging the pair of electrodes and for desorbing ions from the pair of electrodes. The controller is configured to control the system that the first and second electrochemical desalination devices have interleaved charging and discharging modes of operation. One of the first and second electrochemical desalination devices is in a discharging mode and the at least one pair of electrodes release electrical current, while the other of the first and second electrochemical desalination devices is in a charging mode of operation and receives the electrical current released from said one of the first and second electrochemical desalination device.

摘要翻译： 电化学脱盐系统包括第一和第二电化学装置和控制器。 第一和第二电化学装置各自包括电化学脱盐模块，其包括至少一对电极和用于接收电解质溶液的每对电极之间的隔室。 第一和第二电化学脱盐装置中的每一个包括多个连续的操作循环。 每个循环包括用于对每对电极进行充电并用于将电解质中的离子吸附在电极上的充电操作模式，以及用于对该电极放电和用于从一对电极解吸离子的放电模式。 控制器被配置为控制系统，第一和第二电化学脱盐装置具有交错的充放电操作模式。 第一和第二电化学脱盐装置之一处于放电模式，并且至少一对电极释放电流，而第一和第二电化学脱盐装置中的另一个处于充电操作模式并且接收释放的电流 从所述第一和第二电化学脱盐装置中的一个。