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公开(公告)号：US20120107240A1
公开(公告)日：2012-05-03
申请号：US13373072
申请日：2011-11-03
申请人： Shuanglong Liu , Hongguang Liu , Zhen Cheng
发明人： Shuanglong Liu , Hongguang Liu , Zhen Cheng
IPC分类号： A61K51/00 , C07D211/78 , C12Q1/02
CPC分类号： A61K51/0459 , C07D213/81 , G01N33/5011 , G01N33/5088 , G01N33/5743 , G01N33/60 , G01N2800/52
摘要： Embodiments of the present disclosure provide for labeled probes such as a 3-18F-fluoropicolinamide probe, methods of making labeled probes, pharmaceutical compositions including labeled probes, methods of using labeled probes, methods of diagnosing, localizing, monitoring, and/or assessing melanin related diseases, cancers, tumors, precancerous cells, and related biological events (e.g., malignant melanoma), using labeled probes, kits for diagnosing, localizing, monitoring, and/or assessing melanin related diseases, cancers, tumors, precancerous cells, and related biological events, using labeled probes, and the like.
摘要翻译： 本公开的实施方案提供了标记的探针，例如3-18F-氟吡啶酰胺探针，制备标记探针的方法，包括标记探针的药物组合物，使用标记探针的方法，诊断，定位，监测和/或评估黑色素的方法 使用标记的探针，用于诊断，定位，监测和/或评估黑色素相关疾病，癌症，肿瘤，癌前期细胞和相关的试剂盒的相关疾病，癌症，肿瘤，癌前期细胞和相关生物学事件（例如，恶性黑素瘤） 生物学事件，使用标记探针等。
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2.发明授权公开(公告)号：US08753605B2
公开(公告)日：2014-06-17
申请号：US13199428
申请日：2011-08-30
申请人： Zhen Cheng , Sanjiv Sam Gambhir , Zheng Miao , Hongguang Liu , Gang Ren
发明人： Zhen Cheng , Sanjiv Sam Gambhir , Zheng Miao , Hongguang Liu , Gang Ren
CPC分类号： A61K49/0004 , A61K38/16 , A61K49/0008 , A61K49/14 , A61K51/08 , A61K51/088 , G01N33/574 , G01N33/74 , G01N2333/71
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of detecting the over-expression of epidermal growth factor receptor (EGFR) in a subject or sample, methods of diagnosing the presence of one or more angiogenesis related diseases or related biological events in a subject or sample, method of monitoring the progress of one or more angiogenesis related diseases or related biological events in a subject or sample, a 18F-FBEM-CYS-ZEGFR:1907 probe, compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe, and pharmaceutical compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe and the like.
摘要翻译： 根据本公开的目的，如本文所体现和广泛描述的，本公开的实施方案在一方面涉及检测受试者中表皮生长因子受体（EGFR）的过度表达的方法 或样品，诊断受试者或样品中一种或多种血管生成相关疾病或相关生物事件的存在的方法，监测受试者或样品中一种或多种血管生成相关疾病或相关生物学事件进展的方法，18F- FBEM-CYS-ZEGFR：1907探针，包含18F-FBEM-CYS-ZEGFR：1907探针的组合物和包含18F-FBEM-CYS-ZEGFR：1907探针等的药物组合物。
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公开(公告)号：US10517964B2
公开(公告)日：2019-12-31
申请号：US13406891
申请日：2012-02-28
摘要： Embodiments of the present disclosure provide for radionuclide probes, methods of using the radionuclide probes, methods of detecting an optical signal from radionuclides, methods of detecting an optical signal from a quantum dot(s) that receives optical energy from a radionuclide(s), system for analyzing optical energy emitted by a radionuclide(s), system for imaging a target within a living subject or a sample, methods of imaging a disease or condition, and the like.
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4.发明申请OPTICAL IMAGING PROBES, OPTICAL IMAGING SYSTEMS, METHODS OF OPTICAL IMAGING, AND METHODS OF USING OPTICAL IMAGING PROBES 审中-公开光学成像探针，光学成像系统，光学成像方法和使用光学成像探针的方法公开(公告)号：US20120220870A1
公开(公告)日：2012-08-30
申请号：US13406891
申请日：2012-02-28
CPC分类号： A61K49/0013 , A61B5/0075 , A61B6/037 , A61B6/508 , A61K51/00 , A61K51/0491 , B82Y30/00
摘要： Embodiments of the present disclosure provide for radionuclide probes, methods of using the radionuclide probes, methods of detecting an optical signal from radionuclides, methods of detecting an optical signal from a quantum dot(s) that receives optical energy from a radionuclide(s), system for analyzing optical energy emitted by a radionuclide(s), system for imaging a target within a living subject or a sample, methods of imaging a disease or condition, and the like.
摘要翻译： 本公开的实施例提供放射性核素探针，使用放射性核素探针的方法，从放射性核素检测光信号的方法，从从放射性核素接收光能的量子点检测光信号的方法， 用于分析由放射性核素发射的光能的系统，用于对活体或样品内的靶进行成像的系统，成像疾病或病症的方法等。
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5.发明申请公开(公告)号：US20120052009A1
公开(公告)日：2012-03-01
申请号：US13199428
申请日：2011-08-30
申请人： Zheng Cheng , Sanjiv Sam Gambhir , Zheng Miao , Hongguang Liu , Gang Ren
发明人： Zheng Cheng , Sanjiv Sam Gambhir , Zheng Miao , Hongguang Liu , Gang Ren
IPC分类号： A61K51/08 , G01N33/566 , C07K14/00
CPC分类号： A61K49/0004 , A61K38/16 , A61K49/0008 , A61K49/14 , A61K51/08 , A61K51/088 , G01N33/574 , G01N33/74 , G01N2333/71
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of detecting the over-expression of epidermal growth factor receptor (EGFR) in a subject or sample, methods of diagnosing the presence of one or more angiogenesis related diseases or related biological events in a subject or sample, method of monitoring the progress of one or more angiogenesis related diseases or related biological events in a subject or sample, a 18F-FBEM-CYS-ZEGFR:1907 probe, compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe, and pharmaceutical compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe and the like.
摘要翻译： 根据本公开的目的，如本文所体现和广泛描述的，本公开的实施方案在一方面涉及检测受试者中表皮生长因子受体（EGFR）的过度表达的方法 或样品，诊断受试者或样品中一种或多种血管生成相关疾病或相关生物事件的存在的方法，监测受试者或样品中一种或多种血管生成相关疾病或相关生物学事件进展的方法，18F- FBEM-CYS-ZEGFR：1907探针，包含18F-FBEM-CYS-ZEGFR：1907探针的组合物和包含18F-FBEM-CYS-ZEGFR：1907探针等的药物组合物。
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