公开(公告)号：US6147266A

公开(公告)日：2000-11-14

申请号：US220662

申请日：1998-12-24

申请人： Si-Joon Lee ,  Chang-Kuk Kim ,  Young-Gyun Jung ,  Young-Sun Kang ,  Taik-Keun Kim

发明人： Si-Joon Lee ,  Chang-Kuk Kim ,  Young-Gyun Jung ,  Young-Sun Kang ,  Taik-Keun Kim

IPC分类号： B01J31/08 ,  C07B61/00 ,  C07C29/42 ,  C07C29/44 ,  C07C33/042 ,  C07C33/048 ,  C07C33/04

CPC分类号： C07C29/42

摘要： There is disclosed a method for producing acetylene alcohol compounds in a continuous process, which are produced via ethynylation in which ketones containing a group --CH.sub.2 COCH.sub.2 --, are condensed with acetylenes at a temperature of about 20 to 50.degree. C. under a pressure of about 10 to 30 kg/cm.sup.2 in the presence of a quaternary ammonium hydroxide anion exchange resin having strong basicity in an aprotic solvent by feeding a reactant mixture at an LHSV range of 0.1 to 5.0 and the reactant mixture comprises the acetylene, the ketone and the solvent at a molar ratio of 1.0:0.2-3.0:1.0-4.0.

摘要翻译： 公开了一种在连续方法中生产乙炔醇化合物的方法，其通过乙炔化产生，其中含有基团-CH 2 COCH 2 - 的酮在约20至50℃的温度下在约20至50℃的温度下与乙炔冷凝， 在非质子传递溶剂中具有强碱性的季铵氢氧根阴离子交换树脂的存在下，通过在0.1至5.0的LHSV范围内加入反应物混合物，反应物混合物包括乙炔，酮和溶剂，10至30kg / 摩尔比为1.0:0.2-3.0:1.0-4.0。

公开(公告)号：US07598279B2

公开(公告)日：2009-10-06

申请号：US11407526

申请日：2006-04-20

申请人： Yong Moon Choi ,  Choon-Gil Kim ,  Han-Ju Yi ,  Young-Sun Kang ,  Hyun-Seok Lee

发明人： Yong Moon Choi ,  Choon-Gil Kim ,  Han-Ju Yi ,  Young-Sun Kang ,  Hyun-Seok Lee

IPC分类号： A61K31/445 ,  C07D401/12 ,  C07D249/08 ,  C07D249/04

CPC分类号： C07D257/04 ,  C07D249/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06

摘要： Azole compounds containing carbamoyl group and pharmaceutically useful salts thereof are described. The compounds are effective anticonvulsants which are used in the treatment of disorders of the central nervous system, especially as anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, drug abuse, smoking, ADHD, obesity, sleep disorder, neuropathic pain, stroke, cognitive impairment, neurodegeneration, stroke and muscle spasm.

摘要翻译： 描述了含有氨基甲酰基的唑类化合物及其药用盐。 这些化合物是用于治疗中枢神经系统疾病的有效抗惊厥药，特别是焦虑，抑郁，惊厥，癫痫，偏头痛，双相情感障碍，药物滥用，吸烟，ADHD，肥胖，睡眠障碍，神经性疼痛，中风 ，认知障碍，神经变性，中风和肌肉痉挛。

公开(公告)号：US20060258718A1

公开(公告)日：2006-11-16

申请号：US11407526

申请日：2006-04-20

申请人： Yong Choi ,  Choon-Gil Kim ,  Han-Ju Yi ,  Young-Sun Kang ,  Hyun-Seok Lee

发明人： Yong Choi ,  Choon-Gil Kim ,  Han-Ju Yi ,  Young-Sun Kang ,  Hyun-Seok Lee

IPC分类号： A61K31/4192 ,  C07D249/16 ,  A61K31/41

CPC分类号： C07D257/04 ,  C07D249/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06

摘要： Azole compounds containing carbamoyl group and pharmaceutically useful salts thereof are described. The compounds are effective anticonvulsants which are used in the treatment of disorders of the central nervous system, especially as anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, drug abuse, smoking, ADHD, obesity, sleep disorder, neuropathic pain, stroke, cognitive impairment, neurodegeneration, stroke and muscle spasm.