公开(公告)号：US06433152B1

公开(公告)日：2002-08-13

申请号：US09530769

申请日：2000-07-03

申请人： Siegmund Lang ,  Andreas Brakemeier ,  Dieter Wullbrandt ,  Andreas Seiffert-Störicko

发明人： Siegmund Lang ,  Andreas Brakemeier ,  Dieter Wullbrandt ,  Andreas Seiffert-Störicko

IPC分类号： C07G300

CPC分类号： C11D1/667 ,  A01N43/16 ,  A61K8/602 ,  A61K2800/85 ,  A61Q19/00 ,  C07H15/04 ,  C12P19/46

摘要： The invention relates to sophoroselipids of formula (I) wherein R4 represents H, —CH2CH3, —CH2CH2CH3, n is an integer number from 2 to 27, R1 and R2 represent, independently from each other, H or a group of formula (II), and R3 represents H or —OH. The invention also relates to a method for producing sophoroselipids of formula (I) wherein R1, R2, R3 and n have the aforementioned meanings and R4 represents —CH3, —CH2CH3 or —CH2CH2CH3. According to this method, a yeast capable of secreting a sophoroselipid in the form of a lactone in the culture excess, is fermented in a culture medium containing a glycerin. a succinate, a mono-, di- and/or tri-saccharide and a lipid precursor, said sophoroslipid being then isolated from the culture solution. The inventive method is characterised in that the lipid precursor contains one or more 3-alkanols, 4-alkanols or an alkanone with a chain length from 6 to 30 carbon atoms or mixtures of said alkanoistalkanone. Furthermore, according to a variant of the aforementioned method for producing sophoroselipids of formula (I), wherein R1, R2, R3 and n have the meanings aforementioned and R4 represents —CH3, —CH2CH3 or —CH2CH2CH3, the culture medium is maintained during fermentation under a reduced oxygen concentration. The new sophoroselipids may be used, e.g., as surfactants, cosmetics, disinfecting agents or pharmaceutical products.

摘要翻译： 本发明涉及式（I）的槐糖脂，其中R 4表示H，-CH 2 CH 3，-CH 2 CH 2 CH 3，n是2至27的整数，R 1和R 2彼此独立地表示H或式（II）的基团， ，R 3表示H或-OH。 本发明还涉及制备式（I）的槐糖脂的方法，其中R 1，R 2，R 3和n具有上述含义，R 4表示-CH 3，-CH 2 CH 3或-CH 2 CH 2 CH 3。 根据该方法，将能够分泌培养过量的内酯形式的槐糖脂的酵母在含有甘油的培养基中发酵。 琥珀酸盐，单糖，二糖和/或三糖和脂质前体，然后从培养溶液中分离出所述槐糖脂。 本发明的方法的特征在于脂质前体含有一个或多个3-链烷醇，4-链烷醇或链长为6-30个碳原子的烷酮或所述烷酰基烷酮的混合物。 此外，根据上述制备式（I）的槐糖脂的方法的变体，其中R1，R2，R3和n具有上述含义，R4代表-CH3，-CH2CH3或-CH2CH2CH3，培养基在发酵期间保持 在氧浓度降低的情况下。 可以使用新的槐糖脂，例如作为表面活性剂，化妆品，消毒剂或药物产品。

公开(公告)号：US5767255A

公开(公告)日：1998-06-16

申请号：US650852

申请日：1996-05-20

申请人： Dieter Wullbrandt ,  Carlo Giani ,  Andreas Brakemeier ,  Siegmund Lang ,  Fritz Wagner

发明人： Dieter Wullbrandt ,  Carlo Giani ,  Andreas Brakemeier ,  Siegmund Lang ,  Fritz Wagner

IPC分类号： B01F17/56 ,  C07H15/04 ,  C07H15/26 ,  C11D1/68 ,  C12P19/44 ,  C12R1/72 ,  C07H1/00 ,  C07G3/00 ,  C07H13/04

CPC分类号： C07H15/04 ,  C12P19/44

摘要： The present invention relates to glucose- and sophorose-lipids of the formula I ##STR1## in which R.sup.4 is --OH or a group of the formula II, ##STR2## n is an integer from 2 to 26, R.sup.1 and R.sup.2 are, independently of one another, H or ##STR3## R.sup.3 is H or --OH in the case where R.sup.4 is --OH, and is H or --OH or a group of the formula III, ##STR4## in the case where R.sup.4 is a group of the formula II, to a process for obtaining them by fermentation, and to their use as surfactants.

摘要翻译： 本发明涉及式I的葡萄糖和槐糖 - 脂质，其中R 4是-OH或式II的基团，其中n是2至26的整数，R 1和R 2是 在R 4为-OH的情况下，H或R 3为H或-OH，并且在R 4为氢或-OH的情况下为H或-OH或式III， 一组式II，涉及通过发酵获得它们的方法，以及它们作为表面活性剂的用途。