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公开(公告)号：US11446652B2
公开(公告)日：2022-09-20
申请号：US17595802
申请日：2020-05-08
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： Jason Bryant , Eric Yeaton , Dan Harris , Josiah Hackendorf , Steven Allen , Mark Talmer
Abstract: Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.
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公开(公告)号：US20220379300A1
公开(公告)日：2022-12-01
申请号：US17818144
申请日：2022-08-08
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： Jason Bryant , Eric Yeaton , Dan Harris , Josiah Hackendorf , Steven Allen , Mark Talmer
Abstract: Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.
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公开(公告)号：US20220143596A1
公开(公告)日：2022-05-12
申请号：US17595802
申请日：2020-05-08
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： Jason Bryant , Eric Yeaton , Dan Harris , Josiah Hackendorf , Steven Allen , Mark Talmer
Abstract: Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.
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公开(公告)号：US11638917B2
公开(公告)日：2023-05-02
申请号：US17818144
申请日：2022-08-08
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： Jason Bryant , Eric Yeaton , Dan Harris , Josiah Hackendorf , Steven Allen , Mark Talmer
Abstract: Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.
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