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公开(公告)号：US10281480B2
公开(公告)日：2019-05-07
申请号：US14643938
申请日：2015-03-10
发明人： Juergen Patzke
摘要： The present invention is in the field of coagulation diagnostics and relates to methods for detecting modulators of GPIb-thrombin interaction in a sample. To this end, the sample is contacted with isolated mutated GPIbα protein and thrombin, and the formation of a complex between mutated GPIbα protein and thrombin is determined.
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2.发明授权公开(公告)号：US09869683B2
公开(公告)日：2018-01-16
申请号：US14964737
申请日：2015-12-10
IPC分类号： G01N33/53 , G01N33/68 , G01N33/566 , G01N33/543 , G01N33/553 , C12Q1/37 , G01N33/86
CPC分类号： G01N33/6893 , C12Q1/37 , G01N33/543 , G01N33/54313 , G01N33/553 , G01N33/566 , G01N33/68 , G01N33/86 , G01N2333/755 , G01N2333/96486 , G01N2800/222 , G01N2800/226
摘要： Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
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公开(公告)号：US20240345119A1
公开(公告)日：2024-10-17
申请号：US18619034
申请日：2024-03-27
发明人： Juergen Patzke
CPC分类号： G01N35/04 , G01N2035/00346 , G01N2035/0434
摘要： An automatic analysis system (1) for analyzing a sample (23), the analysis system (1) comprising a first device (2) for storing cartridges (3) at a first temperature (T1), the first temperature (T1) being less than 268.15 kelvin.
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4.发明申请公开(公告)号：US20180088133A1
公开(公告)日：2018-03-29
申请号：US15835914
申请日：2017-12-08
IPC分类号： G01N33/68 , G01N33/543 , G01N33/553 , G01N33/86 , C12Q1/37 , G01N33/566
CPC分类号： G01N33/6893 , C12Q1/37 , G01N33/543 , G01N33/54313 , G01N33/553 , G01N33/566 , G01N33/68 , G01N33/86 , G01N2333/755 , G01N2333/96486 , G01N2800/222 , G01N2800/226
摘要： Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
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5.发明申请公开(公告)号：US20150260736A1
公开(公告)日：2015-09-17
申请号：US14643938
申请日：2015-03-10
发明人： Juergen Patzke
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N2333/745 , G01N2333/755 , G01N2333/974
摘要： The present invention is in the field of coagulation diagnostics and relates to methods for detecting modulators of GPIb-thrombin interaction in a sample. To this end, the sample is contacted with isolated mutated GPIbα protein and thrombin, and the formation of a complex between mutated GPIbα protein and thrombin is determined.
摘要翻译： 本发明涉及凝血诊断领域，涉及用于检测样品中GPIb-凝血酶相互作用的调节剂的方法。 为此，将样品与分离的突变GPIbα蛋白和凝血酶接触，确定突变的GPIbα蛋白与凝血酶之间的复合物的形成。
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公开(公告)号：US20190227084A1
公开(公告)日：2019-07-25
申请号：US16379672
申请日：2019-04-09
发明人： Juergen Patzke
IPC分类号： G01N33/86
摘要： The present invention is in the field of coagulation diagnostics and relates to methods for detecting modulators of GPIb-thrombin interaction in a sample. To this end, the sample is contacted with isolated mutated GPIbα protein and thrombin, and the formation of a complex between mutated GPIbα protein and thrombin is determined.
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7.发明授权公开(公告)号：US10591490B2
公开(公告)日：2020-03-17
申请号：US15835914
申请日：2017-12-08
IPC分类号： G01N33/53 , G01N33/68 , G01N33/566 , G01N33/543 , G01N33/553 , C12Q1/37 , G01N33/86
摘要： Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
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8.发明申请公开(公告)号：US20180067022A1
公开(公告)日：2018-03-08
申请号：US15698618
申请日：2017-09-07
发明人： Juergen Patzke
CPC分类号： G01N1/4077 , G01N33/92 , G01N2001/4083 , G01N2800/044
摘要： The present invention is in the field of in vitro diagnostics and relates to a method for preparing lipemic plasma or serum samples and the use thereof for establishing a lipid interference in the quantitative determination of the amount or the activity of an analyte in a plasma or serum sample.
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公开(公告)号：US09766234B2
公开(公告)日：2017-09-19
申请号：US13779904
申请日：2013-02-28
发明人： Juergen Patzke
IPC分类号： G01N33/566 , G01N33/86
CPC分类号： G01N33/566 , G01N33/86 , G01N2333/755
摘要： The invention relates to a screening process for determining a disordered von Willebrand factor (VWF)-GPIb interaction in a patient's sample. This comprises contacting the sample with isolated GPIb.alpha. protein, with VWF protein and with a solid phase associated with an antibody specific for said isolated GPIb.alpha. protein, and determining complex formation.
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10.发明申请Methods And Kits For Determining Von Willebrand Factor Activity In The Absence Of Ristocetin 有权方法和试剂盒用于确定不含赖斯托菌素时的血管性血友病因子活性公开(公告)号：US20160231331A1
公开(公告)日：2016-08-11
申请号：US14964737
申请日：2015-12-10
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N33/543 , G01N33/54313 , G01N33/553 , G01N33/566 , G01N33/68 , G01N33/86 , G01N2333/755 , G01N2333/96486 , G01N2800/222 , G01N2800/226
摘要： Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
摘要翻译： 本文描述的是在不存在瑞斯他汀的情况下测定样品中的血管性血友病因子（VWF）活性的方法，试剂盒，试剂等。
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