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公开(公告)号：US20160317609A1
公开(公告)日：2016-11-03
申请号：US15034844
申请日：2014-11-07
发明人： Ivan Coulter , Vincenzo Aversa , Monica Rosa
CPC分类号： A61K38/13 , A61K9/0053 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5036 , A61K9/5047 , A61K9/5073
摘要： A modified release composition comprising cyclosporin A for oral administration. The composition may comprise a core and a modified release coating, wherein the core comprises a hydrogel-forming polymer matrix and cyclosporin A. The composition may be in the form of a minibead. The compositions provide a pharmacokinetic profile and dissolution profile which provides release of cyclosporin A in the lower GI tract whilst minimising systemic exposure. Also disclosed are uses of the composition in the treatment of conditions affecting the lower GI tract, particularly the colon.
摘要翻译： 一种包含口服给药的环孢菌素A的改良组合物。 组合物可以包含芯和改性释放包衣，其中芯包含形成水凝胶的聚合物基质和环孢菌素A.组合物可以是微型载体的形式。 组合物提供药代动力学特征和溶出曲线，其提供在下GI胃中释放环孢菌素A，同时使全身暴露最小化。 还公开了该组合物在治疗影响下胃肠道，特别是结肠的病症中的用途。
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公开(公告)号：US20180360909A1
公开(公告)日：2018-12-20
申请号：US16110795
申请日：2018-08-23
发明人： Ivan Coulter , Vincenzo Aversa , Monica Rosa
摘要： A modified release composition comprising cyclosporin A for oral administration. The composition may comprise a core and a modified release coating, wherein the core comprises a hydrogel-forming polymer matrix and cyclosporin A. The composition may be in the form of a minibead. The compositions provide a pharmacokinetic profile and dissolution profile which provides release of cyclosporin A in the lower GI tract whilst minimising systemic exposure. Also disclosed are uses of the composition in the treatment of conditions affecting the lower GI tract, particularly the colon.
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公开(公告)号：US20160310561A1
公开(公告)日：2016-10-27
申请号：US15034847
申请日：2014-11-07
IPC分类号： A61K38/13 , A61K9/48 , A61K9/00 , A61K31/502 , A61K31/635 , A61K9/50 , A61K31/196
CPC分类号： A61K38/13 , A61K9/0053 , A61K9/1658 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5036 , A61K9/5047 , A61K9/5073 , A61K9/5089 , A61K31/196 , A61K31/502 , A61K31/635 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/36 , A61K47/42
摘要： The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.
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