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    COMPOSITION COMPRISING OIL DROPS
    2.
    发明申请
    COMPOSITION COMPRISING OIL DROPS 有权
    包含油料的组合物

    公开(公告)号：US20160143989A1

    公开(公告)日：2016-05-26

    申请号：US15011372

    申请日：2016-01-29

    申请人： Sigmoid Pharma Limited

    发明人： Ivan Coulter ,  Bernard Francis McDonald ,  Vincenzo Aversa

    IPC分类号： A61K38/13 ,  A61K9/50

    CPC分类号： A61K38/13 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K9/5026 ,  A61K9/5036 ,  A61K9/5047 ,  A61K9/5073 ,  A61K31/436 ,  A61K38/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  Y02A50/465 ,  Y02A50/471 ,  Y02A50/473

    摘要： A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.

    摘要翻译： 组合物包含其中分散有油滴的水溶性聚合物基质，该组合物包含活性成分。 本发明包括其中有效原理包括在至少一些油滴中的实施方案以及其中油滴没有主动原理的实施方案。 当含有它们的基质溶解在水性介质中时，油滴被释放。 在一个实施方案中，油滴基本上固定在基质中或由基质固定，并且当基质溶解在水性介质中时，固定化特征丧失。 在某些实施方案中，油滴可统称为本发明组合物的油相。 该产品可以是迷你珠的形式。 油相和/或聚合物基质可各自包括表面活性剂。

    CELECOXIB FORMULATIONS USEFUL FOR TREATING COLORECTAL CANCER
    8.
    发明申请
    CELECOXIB FORMULATIONS USEFUL FOR TREATING COLORECTAL CANCER 审中-公开
    CELECOXIB配方可用于治疗彩色癌

    公开(公告)号：US20150342893A1

    公开(公告)日：2015-12-03

    申请号：US14723314

    申请日：2015-05-27

    申请人： SIGMOID PHARMA LIMITED

    发明人： Ivan Coulter ,  Bernard Francis McDonald ,  Vincenzo Aversa

    IPC分类号： A61K9/48 ,  A61K45/06 ,  A61K31/635

    CPC分类号： A61K45/06 ,  A61K9/1617 ,  A61K9/1658 ,  A61K9/1694 ,  A61K9/4858 ,  A61K9/5047 ,  A61K31/635 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K2300/00

    摘要： An oral celecoxib formulation, the formulation being a multiple minibead formulation wherein the minibeads comprise a hydrogel-forming polymer matrix in which are distributed celecoxib, a polyoxyethylated non-ionic surfactant and an anionic surfactant, the minibeads when combined with water being capable of releasing self-assembly structures comprising surfactant and celecoxib.The formulation may be used for treating colorectal cancer, e.g. for inhibiting, reducing or delaying the initiation and/or progression of colorectal cancer, or for use in reversing colorectal cancer, reducing the burden of colorectal cancer and/or inducing remission of colorectal cancer, or for inhibiting, reducing or delaying metastasis of a colorectal cancer.

    摘要翻译： 口服塞来昔布制剂，该制剂是多重小型制剂，其中微型载体包含形成水凝胶的聚合物基质，其中分布有塞来昔布，聚氧乙烯化非离子表面活性剂和阴离子表面活性剂，当与水结合时能够释放自身的微型体 组合结构包括表面活性剂和塞来昔布。 该制剂可用于治疗结肠直肠癌，例如， 用于抑制，减少或延迟结肠直肠癌的起始和/或进展，或用于逆转结肠直肠癌，减少结肠直肠癌的负担和/或诱导结肠直肠癌的缓解，或用于抑制，减少或延迟结肠直肠的转移 癌症。