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    FORMULATIONS COMPRISING CYCLOSPORIN A
    8.
    发明申请
    FORMULATIONS COMPRISING CYCLOSPORIN A 审中-公开
    包含环磷酰胺A的配方

    公开(公告)号：US20160317609A1

    公开(公告)日：2016-11-03

    申请号：US15034844

    申请日：2014-11-07

    申请人： SIGMOID PHARMA LIMITED

    发明人： Ivan Coulter ,  Vincenzo Aversa ,  Monica Rosa

    IPC分类号： A61K38/13 ,  A61K9/50 ,  A61K9/48 ,  A61K9/00

    CPC分类号： A61K38/13 ,  A61K9/0053 ,  A61K9/4808 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/5026 ,  A61K9/5036 ,  A61K9/5047 ,  A61K9/5073

    摘要： A modified release composition comprising cyclosporin A for oral administration. The composition may comprise a core and a modified release coating, wherein the core comprises a hydrogel-forming polymer matrix and cyclosporin A. The composition may be in the form of a minibead. The compositions provide a pharmacokinetic profile and dissolution profile which provides release of cyclosporin A in the lower GI tract whilst minimising systemic exposure. Also disclosed are uses of the composition in the treatment of conditions affecting the lower GI tract, particularly the colon.

    摘要翻译： 一种包含口服给药的环孢菌素A的改良组合物。 组合物可以包含芯和改性释放包衣，其中芯包含形成水凝胶的聚合物基质和环孢菌素A.组合物可以是微型载体的形式。 组合物提供药代动力学特征和溶出曲线，其提供在下GI胃中释放环孢菌素A，同时使全身暴露最小化。 还公开了该组合物在治疗影响下胃肠道，特别是结肠的病症中的用途。

    COMPOSITION COMPRISING OIL DROPS
    9.
    发明申请
    COMPOSITION COMPRISING OIL DROPS 有权
    包含油料的组合物

    公开(公告)号：US20160143989A1

    公开(公告)日：2016-05-26

    申请号：US15011372

    申请日：2016-01-29

    申请人： Sigmoid Pharma Limited

    发明人： Ivan Coulter ,  Bernard Francis McDonald ,  Vincenzo Aversa

    IPC分类号： A61K38/13 ,  A61K9/50

    CPC分类号： A61K38/13 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K9/5026 ,  A61K9/5036 ,  A61K9/5047 ,  A61K9/5073 ,  A61K31/436 ,  A61K38/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  Y02A50/465 ,  Y02A50/471 ,  Y02A50/473

    摘要： A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.

    摘要翻译： 组合物包含其中分散有油滴的水溶性聚合物基质，该组合物包含活性成分。 本发明包括其中有效原理包括在至少一些油滴中的实施方案以及其中油滴没有主动原理的实施方案。 当含有它们的基质溶解在水性介质中时，油滴被释放。 在一个实施方案中，油滴基本上固定在基质中或由基质固定，并且当基质溶解在水性介质中时，固定化特征丧失。 在某些实施方案中，油滴可统称为本发明组合物的油相。 该产品可以是迷你珠的形式。 油相和/或聚合物基质可各自包括表面活性剂。

    FORMULATIONS COMPRISING CYCLOSPORIN A
    10.
    发明申请
    FORMULATIONS COMPRISING CYCLOSPORIN A 审中-公开

    公开(公告)号：US20180360909A1

    公开(公告)日：2018-12-20

    申请号：US16110795

    申请日：2018-08-23

    申请人： Sigmoid Pharma Limited

    发明人： Ivan Coulter ,  Vincenzo Aversa ,  Monica Rosa

    IPC分类号： A61K38/13 ,  A61K9/50 ,  A61K9/48 ,  A61K9/00

    摘要： A modified release composition comprising cyclosporin A for oral administration. The composition may comprise a core and a modified release coating, wherein the core comprises a hydrogel-forming polymer matrix and cyclosporin A. The composition may be in the form of a minibead. The compositions provide a pharmacokinetic profile and dissolution profile which provides release of cyclosporin A in the lower GI tract whilst minimising systemic exposure. Also disclosed are uses of the composition in the treatment of conditions affecting the lower GI tract, particularly the colon.