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    Temperature-Insensitive Calcium Phosphate Cements
    1.
    发明申请
    Temperature-Insensitive Calcium Phosphate Cements 有权
    温度不敏感的磷酸钙水泥

    公开(公告)号：US20160206775A1

    公开(公告)日：2016-07-21

    申请号：US15083701

    申请日：2016-03-29

    Applicant: Skeletal Kinetics LLC

    Inventor： Sahil Jalota ,  David C. Delaney ,  Duran N. Yetkinler

    IPC: A61L24/00

    CPC classification number: A61L24/0084 ,  A61K9/0024 ,  A61K33/42 ,  A61L2430/02

    Abstract: Temperature-insensitive calcium phosphate cements and methods of using the same are provided. Aspects of the cements include a dry component having fine and coarse calcium phosphate particulate reactants and a setting fluid which includes a cellulose. The dry component and setting fluid may be combined over a broad temperature range to produce a flowable composition. The resultant flowable composition finds use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.

    Abstract translation: 提供了温度不敏感的磷酸钙水泥及其使用方法。 水泥的方面包括具有细小的和粗糙的磷酸钙颗粒反应物的干组分和包括纤维素的固化液。 干组分和凝固流体可以在宽的温度范围内组合以产生可流动的组合物。 所得到的可流动组合物可用于各种不同的应用，包括修复硬组织缺陷，例如骨缺损如骨折。

    Implantable, Malleable Calcium Phosphate Compositions and Methods for Making and Using the Same
    2.
    发明申请
    Implantable, Malleable Calcium Phosphate Compositions and Methods for Making and Using the Same 审中-公开
    可植入的，可延展的磷酸钙组合物及其制备和使用方法

    公开(公告)号：US20150374751A1

    公开(公告)日：2015-12-31

    申请号：US14742532

    申请日：2015-06-17

    Applicant: Skeletal Kinetics, LLC

    Inventor： David C. Delaney ,  Sahil Jalota ,  Duran N. Yetkinler

    IPC: A61K33/42 ,  A61L27/12

    CPC classification number: A61K33/42 ,  A61K9/0024 ,  A61K47/02 ,  A61L27/12 ,  A61L27/58 ,  A61L2430/02

    Abstract: Implantable, malleable calcium phosphate compositions are provided. The compositions include calcium and phosphate reactants and a non-aqueous liquid carrier. Aspects of the invention also include methods of making and using the compositions, as well as kits that include the compositions. The compositions and methods find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.

    Abstract translation: 提供可植入的可延展的磷酸钙组合物。 组合物包括钙和磷酸盐反应物和非水性液体载体。 本发明的方面还包括制备和使用组合物的方法，以及包括组合物的试剂盒。 组合物和方法可用于各种应用，包括修复硬组织缺陷，例如骨缺损。

    Calcium phosphate cements and methods for using the same
    3.
    发明授权
    Calcium phosphate cements and methods for using the same 有权

    公开(公告)号：US10022471B2

    公开(公告)日：2018-07-17

    申请号：US13800694

    申请日：2013-03-13

    Applicant: Skeletal Kinetics, LLC

    Inventor： Brent R. Constantz ,  David Delaney ,  Duran N. Yetkinler

    IPC: A61L27/12

    Abstract: Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.

    Tricalcium Phosphate Coarse Particle Compositions and Methods for Making the Same
    7.
    发明申请
    Tricalcium Phosphate Coarse Particle Compositions and Methods for Making the Same 审中-公开
    磷酸三钙粗颗粒组合物及其制备方法

    公开(公告)号：US20140010880A1

    公开(公告)日：2014-01-09

    申请号：US13928211

    申请日：2013-06-26

    Applicant: Skeletal Kinetics LLC

    Inventor： Sahil Jalota ,  David C. Delaney ,  Duran N. Yetkinler

    IPC: A61K9/14 ,  C01B25/32 ,  A61K47/02

    CPC classification number: A61K9/14 ,  A61K47/02 ,  A61L27/12 ,  C01B25/32 ,  C01B25/327 ,  C04B12/025 ,  C04B35/447 ,  C04B35/6313 ,  Y10T428/2982

    Abstract: Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.

    Abstract translation: 提供了制备磷酸三钙粗颗粒组合物的方法。 方法的方面包括将初始磷酸三钙颗粒组合物转化为羟基磷灰石，烧结所得羟基磷灰石以产生第二磷酸三钙组合物，然后机械操作第二磷酸三钙组合物以产生磷酸三钙粗颗粒组合物。 由此产生的主题方法和组合物可用于各种应用。

    Calcium Phosphate Cements and Methods for Using the Same
    8.
    发明申请
    Calcium Phosphate Cements and Methods for Using the Same 有权
    磷酸钙水泥及其使用方法

    公开(公告)号：US20130273118A1

    公开(公告)日：2013-10-17

    申请号：US13800694

    申请日：2013-03-13

    Applicant: Skeletal Kinetics, LLC

    Inventor： Brent R. Constantz ,  David Delaney ,  Duran N. Yetkinler

    IPC: A61L27/12

    CPC classification number: A61L27/12 ,  Y10S514/951 ,  Y10S514/955

    Abstract: Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.

    Abstract translation: 用于生产可流动组合物的方法和组合物，例如 提供了设置成磷酸钙产品的糊剂。 在本发明方法中，包括钙源和磷酸盐源的干燥反应物与固化流体组合以产生可流动组合物。 本发明方法的特征在于干燥反应物包括平均粒径小于约8μm并具有窄尺寸分布的颗粒状钙和/或磷酸盐反应物。 还提供了组合物本身以及用于实践本发明方法的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如骨缺损。

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