公开(公告)号：US20210007996A1

公开(公告)日：2021-01-14

申请号：US17016528

申请日：2020-09-10

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer TOLEDANO ,  Haim Bar-Simantov ,  Nissim Bilman ,  Leora Shapiro ,  Raed Abu-Reziq ,  Hanan Sertchook

IPC: A61K9/50 ,  C09C3/06 ,  A61K8/11 ,  A61Q19/00 ,  A61K8/67 ,  B01J13/02 ,  A01N25/26 ,  B01J13/22 ,  A61K8/38 ,  A01N53/00 ,  A61K8/25

Abstract: The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.

公开(公告)号：US10653899B2

公开(公告)日：2020-05-19

申请号：US16052635

申请日：2018-08-02

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A01N25/28 ,  A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/50 ,  A61K9/06 ,  A61K8/28 ,  A61K8/29 ,  A61K8/27 ,  A61K8/73 ,  A61K47/02 ,  A61K8/06 ,  F28D20/02

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US20180117369A1

公开(公告)日：2018-05-03

申请号：US15834805

申请日：2017-12-07

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K8/11 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K9/00

CPC classification number: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/671 ,  A61K9/0014 ,  A61K9/5115 ,  A61K9/5192 ,  A61K2800/412 ,  B01J13/14

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US12070629B2

公开(公告)日：2024-08-27

申请号：US17340334

申请日：2021-06-07

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/67 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61K9/50 ,  A61K9/51 ,  B01J13/14 ,  B01J13/18 ,  F28D20/02 ,  A61K47/32 ,  A61K47/38

CPC classification number: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/671 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/10 ,  A61K9/501 ,  A61K9/5115 ,  A61K9/5192 ,  B01J13/14 ,  B01J13/18 ,  F28D20/023 ,  A61K9/5026 ,  A61K47/32 ,  A61K47/38 ,  A61K2800/412

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US09687465B2

公开(公告)日：2017-06-27

申请号：US13686533

申请日：2012-11-27

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Hanan Sertchook ,  Ofer Toledano ,  Haim Bar-Simantov

IPC: A61K31/327 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K9/107 ,  A61K9/50

CPC classification number: A61K31/165 ,  A61K9/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1075 ,  A61K9/501 ,  A61K31/192 ,  A61K31/327 ,  A61K31/704 ,  A61K31/7052 ,  A61K31/7056 ,  A61K47/10 ,  A61K47/14 ,  A61K2300/00

Abstract: The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.

公开(公告)号：US20210290985A1

公开(公告)日：2021-09-23

申请号：US17340334

申请日：2021-06-07

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/06 ,  A61K9/50 ,  B01J13/18 ,  F28D20/02 ,  A61K9/10

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US20180147165A1

公开(公告)日：2018-05-31

申请号：US15879600

申请日：2018-01-25

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Hanan Sertchook ,  Ofer Toledano ,  Haim Bar-Simantov

IPC: A61K31/165 ,  A61K31/327 ,  A61K47/10 ,  A61K9/50 ,  A61K9/107 ,  A61K9/00 ,  A61K47/14 ,  A61K31/7052 ,  A61K31/704 ,  A61K31/192 ,  A61K31/7056 ,  A61K9/06

CPC classification number: A61K31/165 ,  A61K9/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1075 ,  A61K9/501 ,  A61K31/192 ,  A61K31/327 ,  A61K31/704 ,  A61K31/7052 ,  A61K31/7056 ,  A61K47/10 ,  A61K47/14 ,  A61K2300/00

Abstract: The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.

公开(公告)号：US12156946B2

公开(公告)日：2024-12-03

申请号：US17016528

申请日：2020-09-10

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Nissim Bilman ,  Leora Shapiro ,  Raed Abu-Reziq ,  Hanan Sertchook

IPC: A61K9/50 ,  A01N25/26 ,  A01N53/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/38 ,  A61K8/67 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/22 ,  C09C3/06

Abstract: The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.

公开(公告)号：US11071878B2

公开(公告)日：2021-07-27

申请号：US15924331

申请日：2018-03-19

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/06 ,  A61K9/50 ,  B01J13/18 ,  F28D20/02 ,  A61K9/10 ,  A61K47/38 ,  A61K47/32

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.