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公开(公告)号：US07998483B2
公开(公告)日：2011-08-16
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US20090274716A1
公开(公告)日：2009-11-05
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US07022819B2
公开(公告)日：2006-04-04
申请号：US10160237
申请日：2002-06-04
IPC分类号： C07K14/00
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.
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4.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursors of members of the MAGE-C and MAGE-B FAMILIES and uses thereof 有权编码MAGE-C和MAGE-B家族成员的肿瘤排斥抗原前体的分离的核酸分子及其用途公开(公告)号：US06680191B1
公开(公告)日：2004-01-20
申请号：US09468433
申请日：1999-12-17
申请人： Sophie Lucas , Thierry Boon-Falleur
发明人： Sophie Lucas , Thierry Boon-Falleur
IPC分类号： C12M120
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.
摘要翻译： 本发明涉及分离的核酸分子，其编码由细胞毒性T细胞识别的肿瘤细胞表达的抗原，导致表达它的肿瘤细胞的裂解。 本发明还涉及被设计用于编码由肿瘤细胞表达的抗原以及由核酸分子转染的细胞或包含核酸分子的载体的载体。 由于这些代码也是本发明的一部分的核酸分子和抗原的性质引起的各种治疗和诊断用途。
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5.发明授权Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof 失效分离的核酸分子，与MHC分子HLA-A2形成复合物的肽及其用途
公开(公告)号：US5886145A
公开(公告)日：1999-03-23
申请号：US915972
申请日：1997-08-21
IPC分类号： G01N33/50 , A61K35/26 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C07K14/74 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/15 , G01N33/53 , C07H21/04 , C07K7/06 , C07K14/705
CPC分类号： C07K14/4748 , A61K38/00
摘要： New tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as NAG tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as NAG coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了新的肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为NAG肿瘤排斥抗原前体，编码它们的核酸分子被称为NAG编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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公开(公告)号：US5879892A
公开(公告)日：1999-03-09
申请号：US845998
申请日：1997-04-25
IPC分类号： G01N33/53 , A61K31/711 , A61K38/00 , A61K48/00 , A61P35/02 , C07K14/435 , C07K14/47 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/4748 , C12Q1/6886 , A61K38/00 , C12Q2600/158
摘要： The invention describes leukemia associated genes, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a preproTRH, tryptase-L and/or Oct-T1 gene product.
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公开(公告)号：US06271019B1
公开(公告)日：2001-08-07
申请号：US09430854
申请日：1999-10-29
IPC分类号： C12N121
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： The invention describes leukemia associated genes, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a preproTRH, tryptase-L and/or Oct-T1 gene product.
摘要翻译： 本发明描述了白血病相关基因，包括其片段和生物功能变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以前trR，类胰蛋白酶-L和/或Oct-T1基因产物表达为特征的病症的方法和产品。
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8.发明授权
公开(公告)号：US5997872A
公开(公告)日：1999-12-07
申请号：US993118
申请日：1997-12-17
IPC分类号： C12N15/09 , A61P35/00 , C07K14/47 , C07K14/82 , C12N5/10 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N33/569 , A61K39/00 , A61K38/00 , C07H21/04 , G01N33/574
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the DNA sequence or vectors which comprise the DNA sequence. Various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes are also part of this invention.
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9.发明授权Isolated nucleic acid molecule coding for tumor rejection antigen precursor MAGE-C1 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-C1的分离的核酸分子及其用途
公开(公告)号：US6027924A
公开(公告)日：2000-02-22
申请号：US845528
申请日：1997-04-25
IPC分类号： C12N15/09 , A61P35/00 , C07K14/47 , C07K14/82 , C12N5/10 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N33/569 , C12P19/24
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the DNA sequence or vectors which comprise the DNA sequence. Various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes are also part of this invention.
摘要翻译： 本发明涉及编码由细胞毒性T细胞识别的肿瘤细胞表达的抗原的分离的DNA序列，导致表达其的肿瘤细胞的裂解。 本发明还涉及设计用于编码由肿瘤细胞表达的抗原以及由DNA序列转染的细胞或包含DNA序列的载体的载体。 由DNA及其编码的抗原的性质引起的各种治疗和诊断用途也是本发明的一部分。
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公开(公告)号：US5811519A
公开(公告)日：1998-09-22
申请号：US791495
申请日：1997-01-27
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/74 , C12N15/12 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/70539 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/4748
摘要： The invention describes the LL-1 tumor specific gene family, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LL-1 gene product.
摘要翻译： 本发明描述了LL-1肿瘤特异性基因家族，包括其片段和生物功能变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LL-1基因产物表达为特征的病症的方法和产品。
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