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1.发明申请公开(公告)号：US20140370599A1
公开(公告)日：2014-12-18
申请号：US14341974
申请日：2014-07-28
Applicant: Sorin Group Italia S.r.l.
Inventor： Marina Strasly , Giovanni Rolando
IPC: A61K35/12
CPC classification number: A61L27/3687 , A61K35/12 , A61L27/3683
Abstract: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.
Abstract translation: 用于生物假体处理生物组织的方法包括通过包含戊二醛的固定溶液固定生物组织并通过用解毒溶液处理来固定固定的生物组织的步骤。 解毒步骤包括通过用消除溶液处理和用解毒溶液处理来消除磷脂的一种或两种。 消除溶液包括1,2-辛二醇和乙醇。 解毒溶液包括牛磺酸或高半胱氨酸。
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公开(公告)号：US20160158415A1
公开(公告)日：2016-06-09
申请号：US15045126
申请日：2016-02-16
Applicant: Sorin Group Italia S.r.l.
Inventor： Marina Strasly , Vincenzo Cassolaro
IPC: A61L27/36
CPC classification number: A61L27/3687 , A61L27/3604 , A61L2430/40 , C12N5/0652
Abstract: Biological tissues may be prepared for use in biological prostheses. The biological tissue may be fixated with glutaraldehyde and may be subjected to successive treatment of the tissue with a solution containing taurine to neutralize excess aldehyde groups that remain free after fixation.
Abstract translation: 可以制备生物组织用于生物假体。 生物组织可以用戊二醛固定，并且可以用含有牛磺酸的溶液对组织进行连续处理，以中和固定后保持游离的过量醛基。
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3.发明授权公开(公告)号：US09457130B2
公开(公告)日：2016-10-04
申请号：US14966675
申请日：2015-12-11
Applicant: Sorin Group Italia S.r.l.
Inventor： Marina Strasly , Giovanni Rolando
CPC classification number: A61L27/3687 , A61K35/12 , A61L27/3683
Abstract: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.
Abstract translation: 用于生物假体处理生物组织的方法包括通过包含戊二醛的固定溶液固定生物组织并通过用解毒溶液处理来固定固定的生物组织的步骤。 解毒步骤包括通过用消除溶液处理和用解毒溶液处理来消除磷脂的一种或两种。 消除溶液包括1,2-辛二醇和乙醇。 解毒溶液包括牛磺酸或高半胱氨酸。
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4.发明申请公开(公告)号：US20160095957A1
公开(公告)日：2016-04-07
申请号：US14966675
申请日：2015-12-11
Applicant: Sorin Group Italia S.r.l.
Inventor： Marina Strasly , Giovanni Rolando
IPC: A61L27/36
CPC classification number: A61L27/3687 , A61K35/12 , A61L27/3683
Abstract: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.
Abstract translation: 用于生物假体处理生物组织的方法包括通过包含戊二醛的固定溶液固定生物组织并通过用解毒溶液处理来固定固定的生物组织的步骤。 解毒步骤包括通过用消除溶液处理和用解毒溶液处理来消除磷脂的一种或两种。 消除溶液包括1,2-辛二醇和乙醇。 解毒溶液包括牛磺酸或高半胱氨酸。
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