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公开(公告)号：US09895225B2
公开(公告)日：2018-02-20
申请号：US13835508
申请日：2013-03-15
Applicant: Sorin Group Italia S.r.l.
Inventor： Giovanni Rolando , Paolo Gaschino , Antonella Orecchia , Monica Achiluzzi , Massimiliano Ares
IPC: A61F2/24
CPC classification number: A61F2/2445 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0029 , A61F2250/0048
Abstract: A collapsible valve prosthesis includes an armature and a set of prosthetic valve leaflets supported by the armature. The armature is expandable from a contracted condition to an expanded condition for anchoring at an annulus of a natural valve site, and includes a tubular intra-annular portion defining a blood flow lumen having an inflow side and an outflow side. The tubular intra-annular portion supports the prosthetic valve leaflets in the blood flow lumen and is provided with outward formations for coupling with the natural valve site. The armature includes an over-annular portion linked to the intra-annular portion to extend collar-like over the annulus of the natural valve site at the inflow side of the blood flow lumen. The armature may also include an under-annular portion to extend collar-like at the outflow side of the blood flow lumen. The prosthesis may permit mitral valve replacement (MVR) without removing the native valve leaflets and the chordae tendineae.
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2.发明授权公开(公告)号：US09457130B2
公开(公告)日：2016-10-04
申请号：US14966675
申请日：2015-12-11
Applicant: Sorin Group Italia S.r.l.
Inventor： Marina Strasly , Giovanni Rolando
CPC classification number: A61L27/3687 , A61K35/12 , A61L27/3683
Abstract: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.
Abstract translation: 用于生物假体处理生物组织的方法包括通过包含戊二醛的固定溶液固定生物组织并通过用解毒溶液处理来固定固定的生物组织的步骤。 解毒步骤包括通过用消除溶液处理和用解毒溶液处理来消除磷脂的一种或两种。 消除溶液包括1,2-辛二醇和乙醇。 解毒溶液包括牛磺酸或高半胱氨酸。
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公开(公告)号：US09358105B2
公开(公告)日：2016-06-07
申请号：US13835593
申请日：2013-03-15
Applicant: Sorin Group Italia S.r.l.
Inventor： Andrea Marchisio , Giovanni Rolando , Paolo Gaschino
IPC: A61F2/24
CPC classification number: A61F2/2412 , A61F2/2427
Abstract: A support device for implanting a stentless heart valve prosthesis having three leaflets adapted for coapting and defining three corresponding commissures is disclosed. The support device includes a shaft defining a manipulation axis, the shaft having a proximal portion and a distal portion, and three support formations integrally formed and extending from the proximal end of the shaft, the support formations angularly distributed about the manipulation axis of the shaft, such that each of the support formations correspond to locations of each of the commissures of the stentless heart valve prosthesis. The shaft includes a connection portion flexibly connecting the shaft and the support formations to permit a displacement of the manipulation axis with respect to the support formations. The shaft, the plurality of support formations and the connection portion are integrally formed from a single tubular element.
Abstract translation: 公开了一种用于植入无支架心脏瓣膜假体的支撑装置，其具有三个适用于起皱和限定三个相应连合的小叶。 所述支撑装置包括限定操作轴的轴，所述轴具有近端部分和远端部分，以及从所述轴的近端一体地形成并延伸的三个支撑结构，所述支撑结构围绕所述轴的操纵轴线成角度地分布 ，使得每个支撑结构对应于无支架式心脏瓣膜假体的每个连合的位置。 轴包括连接部分，该连接部分柔性地连接轴和支撑结构，以允许操纵轴相对于支撑结构的位移。 轴，多个支撑结构和连接部分由单个管状元件整体形成。
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公开(公告)号：US08685084B2
公开(公告)日：2014-04-01
申请号：US13729636
申请日：2012-12-28
Applicant: Sorin Group Italia S.r.l.
Inventor： Giovanni Rolando , Paolo Gaschino , Monica Achiluzzi , Felice Giuseppe Carlino
IPC: A61F2/24
CPC classification number: A61F2/243 , A61F2/06 , A61F2/064 , A61F2/2409 , A61F2/2427 , A61F2/2436 , A61F2002/9522 , Y10T29/49412
Abstract: A kit for implanting a prosthetic vascular conduit includes a prosthetic vascular conduit for coupling to a prosthetic valve having an annular portion. The conduit includes a terminal collar member for receiving the valve. The kit further includes a holder including a shaft and a hub including a receiving portion configured for housing a prosthetic valve. The conduit is fitted on the holder so that at least a portion of the conduit wraps over the receiving portion of the hub. A sleeve member fitted onto the conduit in a position corresponding to the receiving portion of the hub, and a portion of the collar member is wrapped or folded over the sleeve member. The sleeve member is slidable away from the hub to unwrap the collar member such that it is disposed around the annular portion of a prosthetic valve.
Abstract translation: 用于植入假体血管导管的套件包括用于联接到具有环形部分的假体瓣膜的假体血管导管。 导管包括用于接收阀的端子套环构件。 套件还包括保持器，其包括轴和毂，包括构造成容纳人造瓣膜的接收部分。 导管安装在保持器上，使得至少一部分导管缠绕在毂的接收部分上。 套筒构件在对应于轮毂的接收部分的位置中安装到导管上，并且套环构件的一部分被卷绕或折叠在套筒构件上。 套筒构件可以从轮毂滑动以展开套环构件，使得其围绕假肢瓣膜的环形部分设置。
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公开(公告)号：US09918841B2
公开(公告)日：2018-03-20
申请号：US15433970
申请日：2017-02-15
Applicant: Sorin Group Italia S.r.l.
Inventor： Giovanni Righini , Felice Giuseppe Carlino , Giovanni Rolando
CPC classification number: A61F2/2496 , A61B5/02 , A61B5/103 , A61B5/1076 , A61B5/6871
Abstract: A device for measuring an internal dimension of a native cardiac valve annulus includes an elongated support member having a proximal portion and a distal portion. A measuring portion is coupled to the distal portion, and an indicator is coupled to the proximal portion of the support member. The measuring portion is biased towards a deployed configuration such that when deployed it applies an outwardly directed radial force to the native valve annulus.
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Patent Agency Ranking
公开(公告)号：US20130253643A1
公开(公告)日：2013-09-26
申请号：US13835508
申请日：2013-03-15
Applicant: SORIN GROUP ITALIA S.R.L.
Inventor： Giovanni Rolando , Paolo Gaschino , Antonella Orecchia , Monica Achiluzzi , Massimiliano Ares
IPC: A61F2/24
CPC classification number: A61F2/2445 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0029 , A61F2250/0048
Abstract: A collapsible valve prosthesis includes an armature and a set of prosthetic valve leaflets supported by the armature. The armature is expandable from a contracted condition to an expanded condition for anchoring at an annulus of a natural valve site, and includes a tubular intra-annular portion defining a blood flow lumen having an inflow side and an outflow side. The tubular intra-annular portion supports the prosthetic valve leaflets in the blood flow lumen and is provided with outward formations for coupling with the natural valve site. The armature includes an over-annular portion linked to the intra-annular portion to extend collar-like over the annulus of the natural valve site at the inflow side of the blood flow lumen. The armature may also include an under-annular portion to extend collar-like at the outflow side of the blood flow lumen. The prosthesis may permit mitral valve replacement (MVR) without removing the native valve leaflets and the chordae tendineae.
Abstract translation: 可折叠瓣膜假体包括电枢和由电枢支撑的一组假体瓣膜小叶。 电枢从收缩状态膨胀到膨胀状态，用于锚定在自然阀位的环状部，并且包括限定具有流入侧和流出侧的血流腔的管状环状内部。 管状环形内部部分支撑血流腔中的假体瓣膜小叶，并且设置有用于与天然瓣膜部位联接的向外构造。 电枢包括连接到内环形部分的过环形部分，以在血流腔的流入侧处在自然瓣膜部位的环上延伸颈圈状。 电枢还可以包括在血流腔的流出侧处延伸环状的下环形部分。 假体可以允许二尖瓣置换（MVR），而不需要去除天然瓣叶和腱索。
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公开(公告)号：US20130172991A1
公开(公告)日：2013-07-04
申请号：US13729636
申请日：2012-12-28
Applicant: Sorin Group Italia S.r.l.
Inventor： Giovanni Rolando , Paolo Gaschino , Monica Achiluzzi , Felice Giuseppe Carlino
IPC: A61F2/24
CPC classification number: A61F2/243 , A61F2/06 , A61F2/064 , A61F2/2409 , A61F2/2427 , A61F2/2436 , A61F2002/9522 , Y10T29/49412
Abstract: A kit for implanting a prosthetic vascular conduit includes a prosthetic vascular conduit for coupling to a prosthetic valve having an annular portion. The conduit includes a terminal collar member for receiving the valve. The kit further includes a holder including a shaft and a hub including a receiving portion configured for housing a prosthetic valve. The conduit is fitted on the holder so that at least a portion of the conduit wraps over the receiving portion of the hub. A sleeve member fitted onto the conduit in a position corresponding to the receiving portion of the hub, and a portion of the collar member is wrapped or folded over the sleeve member. The sleeve member is slidable away from the hub to unwrap the collar member such that it is disposed around the annular portion of a prosthetic valve.
Abstract translation: 用于植入假体血管导管的套件包括用于联接到具有环形部分的假体瓣膜的假体血管导管。 导管包括用于接收阀的端子套环构件。 套件还包括保持器，其包括轴和毂，包括构造成容纳人造瓣膜的接收部分。 导管安装在保持器上，使得至少一部分导管缠绕在毂的接收部分上。 套筒构件在对应于轮毂的接收部分的位置中安装到导管上，并且套环构件的一部分被卷绕或折叠在套筒构件上。 套筒构件可以从轮毂滑动以展开套环构件，使得其围绕假肢瓣膜的环形部分设置。
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公开(公告)号：US09138314B2
公开(公告)日：2015-09-22
申请号：US14176533
申请日：2014-02-10
Applicant: Sorin Group Italia S.r.l.
Inventor： Giovanni Rolando , Paolo Gaschino , Monica Achiluzzi , Felice Giuseppe Carlino
CPC classification number: A61F2/243 , A61F2/06 , A61F2/064 , A61F2/2409 , A61F2/2427 , A61F2/2436 , A61F2002/9522 , Y10T29/49412
Abstract: A kit for implanting a prosthetic vascular conduit includes a prosthetic vascular conduit for coupling to a prosthetic valve having an annular portion. The conduit includes a terminal collar member for receiving the valve. The kit further includes a holder including a shaft and a hub including a receiving portion configured for housing a prosthetic valve. The conduit is fitted on the holder so that at least a portion of the conduit wraps over the receiving portion of the hub. A sleeve member fitted onto the conduit in a position corresponding to the receiving portion of the hub, and a portion of the collar member is wrapped or folded over the sleeve member. The sleeve member is slidable away from the hub to unwrap the collar member such that it is disposed around the annular portion of a prosthetic valve.
Abstract translation: 用于植入假体血管导管的套件包括用于联接到具有环形部分的假体瓣膜的假体血管导管。 导管包括用于接收阀的端子套环构件。 套件还包括保持器，其包括轴和毂，包括构造成容纳人造瓣膜的接收部分。 导管安装在保持器上，使得至少一部分导管缠绕在毂的接收部分上。 套筒构件在对应于轮毂的接收部分的位置中安装到导管上，并且套环构件的一部分被卷绕或折叠在套筒构件上。 套筒构件可以从轮毂滑动以展开套环构件，使得其围绕假肢瓣膜的环形部分设置。
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公开(公告)号：US09114010B2
公开(公告)日：2015-08-25
申请号：US13849461
申请日：2013-03-22
Applicant: Sorin Group Italia S.r.l.
Inventor： Paolo Gaschino , Andrea Mariotto , Giovanni Rolando , Massimiliano Ares
CPC classification number: A61F2/2427 , A61F2/0095 , A61F2/2412 , A61F2002/9522
Abstract: A kit for facilitating crimping of a prosthetic heart valve for implantation at an aortic valve site in a human heart, the aortic valve site including a plurality of valve sinuses, the kit comprising a prosthetic aortic heart valve having a tubular structure and a first central axis including an anchoring structure comprising an annular outflow member, an annular inflow member, and a plurality of axial connection formations arranged in pairs angularly distributed around the central axis, and a plurality of leaflets coupled to the anchoring structure and adapted to substantially allow blood flow in a first direction and to substantially prevent blood flow in a second direction. The kit further includes a holder member comprising a first disc support member that includes a central hub and a plurality of bridge elements, wherein the hub and the bridge elements extend axially from opposite sides of the disc support member; and a second ring support member that includes receptacles for coupling with the bridge elements, and a plurality of finger formations protruding axially from the ring member and extending lengthwise along at least a portion of the prosthetic aortic heart valve.
Abstract translation: 一种用于促进假体心脏瓣膜的压接以用于植入人心脏中的主动脉瓣部位的试剂盒，所述主动脉瓣部位包括多个瓣膜窦，该试剂盒包括具有管状结构的假体主动脉瓣心脏瓣膜和第一中心轴线 包括锚定结构，其包括环形流出构件，环形流入构件以及围绕所述中心轴线成角度地分布成对的多个轴向连接结构，以及耦合到所述锚定结构并且适于基本上允许血液流动的多个叶片 第一方向并且基本上防止在第二方向上的血液流动。 该套件还包括保持器构件，其包括第一盘支撑构件，该第一盘支撑构件包括中心轮毂和多个桥接元件，其中轮毂和桥接元件从盘支撑构件的相对侧轴向延伸; 以及第二环支撑构件，其包括用于与所述桥接元件联接的插座，以及从所述环构件轴向突出并沿所述假体主动脉瓣心脏的至少一部分纵向延伸的多个指状结构。
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10.发明申请公开(公告)号：US20140370599A1
公开(公告)日：2014-12-18
申请号：US14341974
申请日：2014-07-28
Applicant: Sorin Group Italia S.r.l.
Inventor： Marina Strasly , Giovanni Rolando
IPC: A61K35/12
CPC classification number: A61L27/3687 , A61K35/12 , A61L27/3683
Abstract: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.
Abstract translation: 用于生物假体处理生物组织的方法包括通过包含戊二醛的固定溶液固定生物组织并通过用解毒溶液处理来固定固定的生物组织的步骤。 解毒步骤包括通过用消除溶液处理和用解毒溶液处理来消除磷脂的一种或两种。 消除溶液包括1,2-辛二醇和乙醇。 解毒溶液包括牛磺酸或高半胱氨酸。
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