公开(公告)号：US08920658B2

公开(公告)日：2014-12-30

申请号：US14186649

申请日：2014-02-21

申请人： Spectra Analysis Instruments, Inc.

发明人： William W. Carson ,  Sidney Bourne

IPC分类号： G01N30/12 ,  G01N35/10 ,  B01D15/08 ,  B01D45/12 ,  H01J49/00 ,  B01D1/22 ,  B01D1/00 ,  B01D19/00 ,  G01N30/84 ,  B01D1/16 ,  G01N30/74

CPC分类号： B01D1/222 ,  B01D1/0094 ,  B01D1/16 ,  B01D19/0026 ,  B01D19/0052 ,  B01D19/0057 ,  G01N30/84 ,  G01N2030/743 ,  G01N2030/8494 ,  Y10T436/111666 ,  Y10T436/255 ,  Y10T436/25875

摘要： Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets. When the droplets are sufficiently small, Stokes drag from the exiting solvent vapor carries the droplets out through the center of the cylindrical cavity. After exiting, the superheated solvent vapor further dries the droplets. Solvent vapor is removed by condensation onto a cooled surface. A freezing point reducing agent may be added to improve removal of solvent condensate. Stokes drag from a non-condensable gas maintains the dried droplets in suspension. This suspension travels through an orifice that focuses the impaction of the dried droplets onto the optical surface for infrared analysis. The deposition surface is in an evacuated chamber and is temperature controlled to freeze liquid solutes yet allowing sublimation of residual solvent.

摘要翻译： 公开了在保持溶解的基底的时间分辨率的同时使流动的液体流脱溶的方法和装置。 一种新颖的小型自调节喷雾干燥器保持时间分辨率，同时对液相色谱洗脱液流进行脱溶剂并将溶质沉积在光学表面上用于红外光谱分析。 将液体洗脱液泵送通过加热的雾化器以产生含有液体和溶剂蒸气的溶质的高速射流。 该射流沿周向定向在热的圆柱形空腔内。 离心力使较大的液滴沿腔的外径行进。 加热空腔表面以使液滴沸腾。 薄膜沸腾减少与空腔表面的液滴接触，从而将溶质保留在液滴中。 通过控制溶剂从液滴蒸发的压力来限制溶质温度。 当液滴足够小时，来自离开的溶剂蒸气的斯托克斯阻力将液滴通过圆柱形空腔的中心带出。 离开后，过热溶剂蒸气进一步干燥液滴。 溶剂蒸气通过冷凝除去冷却的表面。 可以加入凝固点还原剂以改善溶剂冷凝物的去除。 来自不可冷凝气体的斯托克斯阻力将干燥的液滴保持在悬浮状态。 该悬浮液通过孔将干燥小滴的冲击聚焦到光学表面上用于红外分析。 沉积表面处于抽真空室中并进行温度控制以冷冻液体溶质，同时允许残留溶剂升华。