公开(公告)号：US5750652A

公开(公告)日：1998-05-12

申请号：US185432

申请日：1994-01-21

申请人： Spyridon Artavanis-Tsakonas ,  Isabelle Busseau ,  Robert J. Diederich ,  Tian Xu ,  Kenji Matsuno

发明人： Spyridon Artavanis-Tsakonas ,  Isabelle Busseau ,  Robert J. Diederich ,  Tian Xu ,  Kenji Matsuno

IPC分类号： A61K38/00 ,  C07H21/00 ,  C07K14/435 ,  C07K14/47 ,  C07K16/18 ,  C07K14/705

CPC分类号： C07H21/00 ,  C07K14/435 ,  C07K14/47 ,  C07K16/18 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to amino acid sequences of the encoded deltex protein. The invention further relates to fragments and other derivatives, and analogs, of deltex proteins. In specific embodiments, the invention relates to deltex protein derivatives and analogs of the invention which are functionally active, or which comprise one or more domains of a deltex protein, including but not limited to the Gln-rich clusters, SH3 binding domains, domains which mediate binding to Notch or to a Notch derivative containing Notch cdc10/SW16/ankyrin ("ANK") repeats, domains which mediate binding to a second deltex protein, or any combination of the foregoing. The present invention also relates to compositions based on deltex proteins.

摘要翻译： 本发明涉及编码的deltex蛋白的氨基酸序列。 本发明还涉及deltex蛋白的片段和其他衍生物和类似物。 在具体实施方案中，本发明涉及在功能上有活性或包含一个或多个deltex蛋白结构域的本发明的脱胶蛋白衍生物和类似物，包括但不限于富含Gln的簇，SH3结合结构域， 介导与Notch或Notch cdc10 / SW16 / ankyrin（“ANK”）的Notch衍生物的结合重复，介导与第二个脱落蛋白结合的结构域，或上述的任何组合。 本发明还涉及基于脱胶蛋白的组合物。