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    Deltex proteins
    1.
    发明授权
    Deltex proteins 失效
    Deltex蛋白

    公开(公告)号：US5750652A

    公开(公告)日：1998-05-12

    申请号：US185432

    申请日：1994-01-21

    申请人： Spyridon Artavanis-Tsakonas ,  Isabelle Busseau ,  Robert J. Diederich ,  Tian Xu ,  Kenji Matsuno

    发明人： Spyridon Artavanis-Tsakonas ,  Isabelle Busseau ,  Robert J. Diederich ,  Tian Xu ,  Kenji Matsuno

    IPC分类号： A61K38/00 ,  C07H21/00 ,  C07K14/435 ,  C07K14/47 ,  C07K16/18 ,  C07K14/705

    CPC分类号： C07H21/00 ,  C07K14/435 ,  C07K14/47 ,  C07K16/18 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention relates to amino acid sequences of the encoded deltex protein. The invention further relates to fragments and other derivatives, and analogs, of deltex proteins. In specific embodiments, the invention relates to deltex protein derivatives and analogs of the invention which are functionally active, or which comprise one or more domains of a deltex protein, including but not limited to the Gln-rich clusters, SH3 binding domains, domains which mediate binding to Notch or to a Notch derivative containing Notch cdc10/SW16/ankyrin ("ANK") repeats, domains which mediate binding to a second deltex protein, or any combination of the foregoing. The present invention also relates to compositions based on deltex proteins.

    摘要翻译： 本发明涉及编码的deltex蛋白的氨基酸序列。 本发明还涉及deltex蛋白的片段和其他衍生物和类似物。 在具体实施方案中，本发明涉及在功能上有活性或包含一个或多个deltex蛋白结构域的本发明的脱胶蛋白衍生物和类似物，包括但不限于富含Gln的簇，SH3结合结构域， 介导与Notch或Notch cdc10 / SW16 / ankyrin（“ANK”）的Notch衍生物的结合重复，介导与第二个脱落蛋白结合的结构域，或上述的任何组合。 本发明还涉及基于脱胶蛋白的组合物。

    Manipulation of non-terminally differentiated cells using the notch pathway
    2.
    发明申请
    Manipulation of non-terminally differentiated cells using the notch pathway 审中-公开
    使用缺口途径操纵非终末分化细胞

    公开(公告)号：US20070166824A1

    公开(公告)日：2007-07-19

    申请号：US11605536

    申请日：2006-11-28

    申请人： Spyridon Artavanis-Tsakonas ,  Mark Fortini ,  Kenji Matsuno

    发明人： Spyridon Artavanis-Tsakonas ,  Mark Fortini ,  Kenji Matsuno

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0623 ,  A61K35/12 ,  A61K38/00 ,  C07K14/47 ,  C12N5/0018 ,  C12N5/0601 ,  C12N2501/42

    摘要： The present invention is directed to methods for the expansion of non-terminally differentiated cells (“precursor cells”) using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.

    摘要翻译： 本发明涉及使用Notch功能的激动剂来扩增非终末分化的细胞（“前体细胞”）的方法，通过抑制细胞的分化而不抑制增殖（有丝分裂活性），使得扩增的非 - 得到终末分化的细胞。 细胞优选是干细胞或祖细胞。 这些扩展的细胞可用于细胞替代疗法以提供所需的细胞群体并有助于患病和/或损伤组织的再生。 扩增的细胞群体也可以重组并用于基因治疗，或可用于提供与特定前体细胞或其后代细胞相关的功能。

    Manipulation of non-terminally differentiated cells using the Notch pathway
    5.
    发明申请
    Manipulation of non-terminally differentiated cells using the Notch pathway 审中-公开
    使用Notch途径操纵非终末分化细胞

    公开(公告)号：US20050158859A1

    公开(公告)日：2005-07-21

    申请号：US10746237

    申请日：2003-12-22

    申请人： Spyridon Artavanis-Tsakonas ,  Mark Fortini ,  Kenji Matsuno

    发明人： Spyridon Artavanis-Tsakonas ,  Mark Fortini ,  Kenji Matsuno

    IPC分类号： A61K35/12 ,  A61K38/00 ,  C07K14/47 ,  C12N5/00 ,  C12N5/07 ,  A61K48/00 ,  C12N5/08 ,  C12N15/85

    CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  C12N5/0018 ,  C12N5/0601 ,  C12N2501/42

    摘要： The present invention is directed to methods for the expansion of non-terminally differentiated cells (“precursor cells”) using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.

    摘要翻译： 本发明涉及使用Notch功能的激动剂来扩增非终末分化的细胞（“前体细胞”）的方法，通过抑制细胞的分化而不抑制增殖（有丝分裂活性），使得扩增的非 - 得到终末分化的细胞。 细胞优选是干细胞或祖细胞。 这些扩展的细胞可用于细胞替代疗法以提供所需的细胞群体并有助于患病和/或损伤组织的再生。 扩增的细胞群体也可以重组并用于基因治疗，或可用于提供与特定前体细胞或其后代细胞相关的功能。

    Methods and apparatus for manufacturing tubes
    7.
    发明授权
    Methods and apparatus for manufacturing tubes 失效
    用于制造管子的方法和装置

    公开(公告)号：US4800250A

    公开(公告)日：1989-01-24

    申请号：US64548

    申请日：1987-06-22

    申请人： Michio Watanabe ,  Kazuhisa Ishibashi ,  Kenji Matsuno ,  Hideo Kurashima

    发明人： Michio Watanabe ,  Kazuhisa Ishibashi ,  Kenji Matsuno ,  Hideo Kurashima

    IPC分类号： B21D51/26 ,  B21C37/08 ,  B23K26/26 ,  B23K26/00

    CPC分类号： B21C37/0822 ,  B21C37/08 ,  B23K26/262

    摘要： A method and apparatus for guiding the opposed edges of sheet material into substantially abutting edge-to-edge relationship with one another and thereafter welding said edges by a high energy welding source to form a seam. The invention enables the continuous high speed butt welding of the sheet material to form cylindrical bodies. The apparatus includes three elements, a mandrel, a mandrel holder and tube holders. Sheet material is fed to around said mandrel and advanced by a tube holder with an edge of two opposite edges of said sheet material being in intimate contact with a basis plane of said mandrel holder. Another edges is slided into contact with above mentioned edge of sheet material making abutting relationship after passing through the basis plane of said mandrel holder. These abutting edges pass a high energy zone of a welder and butt welded to make a tube.

    摘要翻译： 一种用于将片材的相对边缘引导成彼此基本上邻接的边缘到边缘关系的方法和装置，然后通过高能量焊接源焊接所述边缘以形成接缝。 本发明能够使片材的连续高速对接焊接形成圆柱体。 该装置包括三个元件，心轴，心轴保持器和管座。 片材被馈送到所述心轴周围并由管保持器推进，其中所述片材的两个相对边缘的边缘与所述心轴保持器的基础平面紧密接触。 另外的边缘与上述片材的边缘滑动接触，在穿过所述心轴保持器的基面之后形成邻接关系。 这些邻接边缘通过焊机的高能区域并对接焊接以制造管。

    Method of electric welding tinfree cans
    8.
    发明授权
    Method of electric welding tinfree cans 失效
    无锡罐焊接方法

    公开(公告)号：US4334138A

    公开(公告)日：1982-06-08

    申请号：US150775

    申请日：1980-05-19

    申请人： Kenji Matsuno ,  Hiroyuki Funamoto

    发明人： Kenji Matsuno ,  Hiroyuki Funamoto

    IPC分类号： B23K11/06 ,  B23K11/30

    CPC分类号： B23K11/063 ,  B23K11/309 ,  B23K2201/12

    摘要： Disclosed are a method of and apparatus for making a welded metallic can body by effecting a mash resistance welding on a lapped side portion of a can body preform by means of a combination of a cooled elongated electrode and a cooled rotary electrode and, as required, with wire electrodes interposed between the lapped side portion and these electrodes. Also, disclosed are a tinfree steel welded can body and its making method wherein it is formed by a mash resistance welding on a lapped side portion of a can body preform made from tinfree steel, without requiring the removal of surface chromium film from the welded portion and its vicinity.

    摘要翻译： 公开了一种通过冷却的细长电极和冷却的旋转电极的组合在罐体预制件的搭接侧部分上进行防咬焊焊接来制造焊接金属罐体的方法和装置，并且根据需要， 其中线电极介于重叠侧部分和这些电极之间。 此外，公开了一种无锡钢焊接罐体及其制造方法，其通过在由无锡钢制成的罐体预制件的搭接侧部分上的防咬焊而形成，而不需要从焊接部分去除表面铬膜 及其附近。