专利检索 ap:("Sreenivasulu MEGATI" OR "Panolil RAVEENDRANATH" OR "Girija Raveendranath" OR "Vijay Raveendranath" OR "Sanjay Raveendranath") AND inv:"Vijay Raveendranath" 第 1 页

1.

发明申请
PROCESS FOR SELECTIVE SULFATION OF AROMATIC HYDROXYL GROUPS 审中-公开
标题翻译：芳香羟基选择性硫化方法

公开(公告)号：US20080194533A1

公开(公告)日：2008-08-14

申请号：US12027502

申请日：2008-02-07

申请人： Sreenivasulu MEGATI , Panolil RAVEENDRANATH , Girija Raveendranath , Vijay Raveendranath , Sanjay Raveendranath

发明人： Sreenivasulu MEGATI , Panolil RAVEENDRANATH , Girija Raveendranath , Vijay Raveendranath , Sanjay Raveendranath

IPC分类号： A61K31/566 , C07J1/00 , A61P5/24 , A61P19/08 , A61P35/00 , A61P9/00 , C12N5/06

CPC分类号： C07J31/006

摘要： The present invention relates to processes for selective sulfation of an aromatic hydroxyl group over an aliphatic hydroxyl group where both are present in the same molecule. This invention also relates to processes for selective sulfation of the aromatic hydroxyl group of equilin, equilenin, estradiol, estra(1,3,5-triene)-3,16,17-triol, dihydroequilenin or dihydroequilin. This invention further relates to alkali metal salts of dihydroequilenin sulfates, dihydroequilin sulfates, estradiol sulfates, and estriol sulfates, processes for making thereof, stable compositions comprising thereof, and the use thereof.

摘要翻译： 本发明涉及在脂肪族羟基上选择性硫酸化芳族羟基的方法，其中两者都存在于同一分子中。本发明还涉及用于选择性硫酸化平衡，平衡，雌二醇，雌二醇（1,3,5-三烯）-3,16,17-三醇，二氢马来西林或二氢马雌二醇的芳族羟基的方法。本发明还涉及硫酸二氢马来酰氯，二氢巯基硫酸盐，雌二醇硫酸盐和雌三醇硫酸盐的碱金属盐，其制备方法，包含它们的稳定组合物及其用途。

2.

发明申请
SYNTHESIS OF PYRROLIDINE COMPOUNDS 审中-公开
标题翻译：吡咯烷酮化合物的合成

公开(公告)号：US20100249207A1

公开(公告)日：2010-09-30

申请号：US12690043

申请日：2010-01-19

申请人： Asaf R. Alimardanov , Lalitha Krishnan , Maotang Zhou , Ting-Zhong Wang , Jianxin Ren , John Leo Considine , Charles C. Wu , Jason Brazzillo , Panolil Raveendranath , Karen Sutherland , Mahmoud Mirmehrabi , Subodh S. Deshmukh , Girija Raveendranath , Vijay Raveendranath , Sanjay Raveendranath

发明人： Asaf R. Alimardanov , Lalitha Krishnan , Maotang Zhou , Ting-Zhong Wang , Jianxin Ren , John Leo Considine , Charles C. Wu , Jason Brazzillo , Panolil Raveendranath , Karen Sutherland , Mahmoud Mirmehrabi , Subodh S. Deshmukh , Girija Raveendranath , Vijay Raveendranath , Sanjay Raveendranath

IPC分类号： A61K31/40 , C07D207/14 , A61P9/10 , A61P3/10 , A61P25/00 , A61P35/00 , A61P39/00 , A61P39/06 , A61P3/14 , A61P9/00

CPC分类号： C07D207/16

摘要： Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

摘要翻译： 提供制备某些取代的吡咯烷化合物的方法，（2S，4R）-1-（2-氨基乙酰基）-4-苯甲酰基吡咯烷-2-甲酸盐酸盐的形式，以及制备和使用这些形式的方法。

3.

发明申请
PROCESS FOR THE MANUFACTURE OF BENZYLSULFONYLARENES 审中-公开
标题翻译：制备苯甲醚的方法

公开(公告)号：US20090012308A1

公开(公告)日：2009-01-08

申请号：US12135350

申请日：2008-06-09

申请人： Mahmut Levent , Panolil Raveendranath , Sanjay Raveendranath , Vijay Raveendranath , Girija Raveendranath

发明人： Mahmut Levent , Panolil Raveendranath , Sanjay Raveendranath , Vijay Raveendranath , Girija Raveendranath

IPC分类号： C07D231/56 , C07C315/00

CPC分类号： C07C315/00 , C07D231/56 , C07C317/14 , C07C317/18

摘要： The present invention provides a process for the manufacture of an arylmethyl-sulfonylarene, R1CH2SO2R2, wherein R1 and R2 are each independently an optionally substituted phenyl or naphthyl group which process comprises reacting an arylmethylhalide, R1CH2-Hal wherein R1 is as defined hereinabove and Hal is Cl, Br or I with a sodium arylsulfinate R2SO2Na wherein R2 is as defined hereinabove in the presence of a base optionally in the presence of a solvent.Also provided is the use of the inventive process in the manufacture of a 3-arylsulfonylindazole 5-HT6 ligand.

摘要翻译： 本发明提供了一种制备芳基甲基磺酰基芳烃R 1 CH 2 SO 2 R 2的方法，其中R 1和R 2各自独立地是任选取代的苯基或萘基，该方法包括使芳基甲基卤，R 1 CH 2 - Hal，其中R 1如上所定义，Hal是 Cl，Br或I与芳基亚磺酸钠R2SO2Na反应，其中R 2如上定义，在碱的存在下，任选地在溶剂存在下。还提供本发明方法在制备3-芳基亚磺酰基吲唑5-HT 6配体中的用途。

4.

发明申请
Process for Preparing Indolinone Phenylaminopropanol Derivatives 审中-公开
标题翻译：制备吲哚啉酮苯基氨基丙醇衍生物的方法

公开(公告)号：US20080146645A1

公开(公告)日：2008-06-19

申请号：US11843364

申请日：2007-08-22

申请人： Anita Wai-Yin Chan , Zhixian Ding , Mousumi Ghosh , Mahmut Levent , Panolil Raveendranath , Jianxin Ren , Maotang Zhou , Asaf Alimardanov , Alexander V. Gontcharov , Antonia A. Nikitenko , John R. Potoski , Girija Raveendranath , Vijay Raveendranath , Sanjay Raveendranath

发明人： Anita Wai-Yin Chan , Zhixian Ding , Mousumi Ghosh , Mahmut Levent , Panolil Raveendranath , Jianxin Ren , Maotang Zhou , Asaf Alimardanov , Alexander V. Gontcharov , Antonia A. Nikitenko , John R. Potoski , Girija Raveendranath , Vijay Raveendranath , Sanjay Raveendranath

IPC分类号： C07D209/34 , A61K31/4015

CPC分类号： C07D209/34

摘要： Processes are disclosed for preparing indolinone phenylaminopropanol derivatives, particularly chiral indolinone phenylaminopropanol derivatives of the general formula: The processes disclosed may be used to prepare, inter alia, 7-fluoro-1-[(1S, 2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one and 7-fluoro-1-[(1S, 2R)-1-(3,5-difluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one. Intermediates of the processes are also disclosed.

摘要翻译： 公开了制备吲哚啉酮苯基氨基丙醇衍生物的方法，特别是具有以下通式的手性吲哚啉酮苯基氨基丙醇衍生物：所公开的方法可用于特别地制备7-氟-1 - [（1S，2R）-1-（3- 氟甲基）-2-羟基-3-（甲基氨基）丙基] -3,3-二甲基-1,3-二氢-2H-吲哚-2-酮和7-氟-1 - [（1S，2R）-1 - （3,5-二氟苯基）-2-羟基-3-（甲基氨基）丙基] -3,3-二甲基-1,3-二氢-2H-吲哚-2-酮。还公开了该方法的中间体。

5.

发明申请
Synthesis of pyrrolidine compounds 审中-公开
标题翻译：吡咯烷化合物的合成

公开(公告)号：US20080188545A1

公开(公告)日：2008-08-07

申请号：US12005118

申请日：2007-12-20

申请人： Asaf R. Alimardanov , Lalitha Krishnan , Maotang Zhou , Ting-Zhong Wang , Jianxin Ren , John Leo Considine , Charles C. Wu , Jason Brazzillo , Panolil Raveendranath , Girija Raveendranath , Vijay Raveendranath , Sanjay Raveeendranath , Karen Sutherland , Mahmoud Mirmehrabi , Subodh S. Deshmukh

发明人： Asaf R. Alimardanov , Lalitha Krishnan , Maotang Zhou , Ting-Zhong Wang , Jianxin Ren , John Leo Considine , Charles C. Wu , Jason Brazzillo , Panolil Raveendranath , Girija Raveendranath , Vijay Raveendranath , Sanjay Raveeendranath , Karen Sutherland , Mahmoud Mirmehrabi , Subodh S. Deshmukh

IPC分类号： A61K31/40 , C07D207/08 , A61P9/06 , A61P9/10

CPC分类号： C07D207/16

摘要： Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

摘要翻译： 提供制备某些取代的吡咯烷化合物的方法，（2S，4R）-1-（2-氨基乙酰基）-4-苯甲酰基吡咯烷-2-甲酸盐酸盐的形式，以及制备和使用这些形式的方法。

6.

发明申请
N'-(2-HALOBENZYLIDENE)SULFONYLHYDRAZIDES AS INTERMEDIATES IN THE MANUFACTURE OF ARYLSULFONYLINDAZOLES 审中-公开
标题翻译： N' - （2-羟基苯甲基）磺酰氯作为芳基磺酰胺的制备中的中间体

公开(公告)号：US20090023925A1

公开(公告)日：2009-01-22

申请号：US12147586

申请日：2008-06-27

申请人： Anita Wai-Yin Chan , Mahmut Levent , David Place , Panolil Raveendranath , Sanjay Raveendranth , Vijay Raveendranath , Girija Raveendranath , Xinxu Shi , Charles Wu

发明人： Anita Wai-Yin Chan , Mahmut Levent , David Place , Panolil Raveendranath , Sanjay Raveendranth , Vijay Raveendranath , Girija Raveendranath , Xinxu Shi , Charles Wu

IPC分类号： C07D241/04 , C07D405/10

CPC分类号： C07C311/49 , C07C303/40 , C07D231/56 , C07D295/135 , C07D295/205

摘要： The present invention provides N′-(2-halobenzylidene)sulfonylhydrazides of formula I Compounds of formula I are useful for the manufacture of 1-arylsulfonylindazole 5-HT6 ligands.

摘要翻译： 本发明提供式I的N' - （2-卤代亚苄基）磺酰基酰肼式I化合物可用于制备1-芳基亚磺酰基吲唑5-HT6配体。