公开(公告)号：US07142635B2

公开(公告)日：2006-11-28

申请号：US11102083

申请日：2005-04-08

申请人： Srijit Kamath ,  Sartaj Sahni ,  Jonathan Gang Li ,  Jatinder Palta ,  Sanjay Ranka

发明人： Srijit Kamath ,  Sartaj Sahni ,  Jonathan Gang Li ,  Jatinder Palta ,  Sanjay Ranka

IPC分类号： A61N5/10

CPC分类号： A61N5/1042 ,  A61N5/1036

摘要： A method of delivering intensity modulated radiation therapy (IMRT) is disclosed. An intensity profile for the treatment of a patient is provided which spans a prescribed field width and includes a discrete profile having intensity values at each of a plurality of sample points bounded by the prescribed width. The prescribed width is compared to a maximum field width provided by the radiation treatment system. The intensity profile is split into a plurality of intensity profile portions, each having respective widths less than the maximum width if the prescribed width is greater than the maximum width. The prescribed field is also divided into a plurality of different profile portion split arrangements. A monitor unit (MU) efficiency is calculated for each of the arrangements. One of the arrangements is selected for delivery by the system using a leaf sequencing method.

摘要翻译： 公开了一种递送强度调制放射治疗（IMRT）的方法。 提供了用于治疗患者的强度分布，其跨越规定的场宽度并且包括在由规定宽度限定的多个采样点中的每一个处具有强度值的离散轮廓。 将规定的宽度与辐射处理系统提供的最大场宽进行比较。 如果规定的宽度大于最大宽度，则强度分布被分成多个强度分布部分，每个强度分布部分各自具有小于最大宽度的宽度。 规定的场也被分成多个不同的轮廓部分割装置。 针对每个布置计算监视器单元（MU）的效率。 选择其中一种安排用于通过系统使用叶片测序方法递送。

公开(公告)号：US20050148841A1

公开(公告)日：2005-07-07

申请号：US10736023

申请日：2003-12-15

申请人： Srijit Kamath ,  Sartaj Sahni ,  Jatinder Palta ,  Sanjay Ranka ,  Jonathan Li

发明人： Srijit Kamath ,  Sartaj Sahni ,  Jatinder Palta ,  Sanjay Ranka ,  Jonathan Li

IPC分类号： A61B5/05 ,  A61N5/10

CPC分类号： A61N5/103 ,  A61N5/1036 ,  A61N5/1042

摘要： A method of delivering radiation treatment using multi-leaf collimation includes the step of providing a radiation fluence map which includes an intensity profile. The fluence map is converted into a preliminary leaf sequence, wherein the preliminary leaf sequence minimizes machine on-time and is generated without leaf movement constraints. The leaf movement constraint is imposed on the preliminary leaf sequence. At least one constraint elimination algorithm is then applied, the algorithm adjusting the preliminary leaf sequence to minimize violations of the constraint while providing the desired fluence map and minimized radiation on-time. The method can be applied to SMLC and DLMC systems, and can include adjustment for the tongue-and-groove effect.

摘要翻译： 使用多叶准直进行放射治疗的方法包括提供包括强度分布的辐射注量图的步骤。 注量图被转换成初步的叶子序列，其中初步叶子序列使机器准时最小化，并且不产生叶片运动限制。 叶片运动约束对初步叶序列施加。 然后应用至少一个约束消除算法，该算法调整初步叶序列以最小化对约束的违反，同时提供期望的通量图和最小化的辐射on-time。 该方法可以应用于SMLC和DLMC系统，并且可以包括对榫槽效应的调整。

公开(公告)号：US20050254623A1

公开(公告)日：2005-11-17

申请号：US11102083

申请日：2005-04-08

申请人： Srijit Kamath ,  Sartaj Sahni ,  Jonathan Li ,  Jatinder Palta ,  Sanjay Ranka

发明人： Srijit Kamath ,  Sartaj Sahni ,  Jonathan Li ,  Jatinder Palta ,  Sanjay Ranka

IPC分类号： A61N5/10

CPC分类号： A61N5/1042 ,  A61N5/1036

摘要： A method of delivering intensity modulated radiation therapy (IMRT) is disclosed. An intensity profile for the treatment of a patient is provided which spans a prescribed field width and includes a discrete profile having intensity values at each of a plurality of sample points bounded by the prescribed width. The prescribed width is compared to a maximum field width provided by the radiation treatment system. The intensity profile is split into a plurality of intensity profile portions, each having respective widths less than the maximum width if the prescribed width is greater than the maximum width. The prescribed field is also divided into a plurality of different profile portion split arrangements. A monitor unit (MU) efficiency is calculated for each of the arrangements. One of the arrangements is selected for delivery by the system using a leaf sequencing method.

摘要翻译： 公开了一种递送强度调制放射治疗（IMRT）的方法。 提供了用于治疗患者的强度分布，其跨越规定的场宽度并且包括在由规定宽度限定的多个采样点中的每一个处具有强度值的离散轮廓。 将规定的宽度与辐射处理系统提供的最大场宽进行比较。 如果规定的宽度大于最大宽度，则强度分布被分成多个强度分布部分，每个强度分布部分各自具有小于最大宽度的宽度。 规定的场也被分成多个不同的轮廓部分割装置。 针对每个布置计算监视器单元（MU）的效率。 选择其中一种安排用于通过系统使用叶片测序方法递送。

公开(公告)号：US07573978B2

公开(公告)日：2009-08-11

申请号：US11995303

申请日：2006-07-11

申请人： Srijit Kamath ,  Sartaj Kumar Sahni ,  Jonathan Li ,  Jatinder Palta ,  Sanjay Ranka

发明人： Srijit Kamath ,  Sartaj Kumar Sahni ,  Jonathan Li ,  Jatinder Palta ,  Sanjay Ranka

IPC分类号： A61N5/10

CPC分类号： A61N5/1042 ,  A61N5/1036 ,  G21K1/04

摘要： A method and associated system 300 for delivering intensity-modulated radiation therapy (IMRT) uses variable feathering field splitting for intensity modulated fields of large size. A processor controls a beam-shaping device that splits the radiation beam into a plurality of radiation fields delivered to a patient. The processor in cooperation with the beam-shaping device implements a variable feathering method which includes providing an intensity matrix for the treatment of a patient, the intensity matrix having a plurality of rows and columns for spanning a prescribed radiation field including a prescribed field width. The prescribed width is compared to a maximum field width provided by the radiation treatment system. The intensity matrix is split into a plurality of spatially overlapping intensity submatrices by variably feathering the intensity matrix when the prescribed width exceeds the maximum field width, Radiotherapy is then provided to the patient using a leaf sequencing method to generate the submatrices.

摘要翻译： 用于递送强度调制辐射治疗（IMRT）的方法和相关系统300使用大尺寸强度调制场的可变羽化场分割。 处理器控制将辐射束分成传递给患者的多个辐射场的光束整形装置。 与光束成形装置协作的处理器实现了一种可变羽化方法，其包括提供用于治疗患者的强度矩阵，所述强度矩阵具有多个行和列，用于跨越包括规定场宽的规定辐射场。 将规定的宽度与辐射处理系统提供的最大场宽进行比较。 当规定的宽度超过最大场宽度时，强度矩阵通过可变地羽化强度矩阵而被分割成多个空间上重叠的强度子矩阵，然后使用叶子排序方法向患者提供放射疗法以产生子矩阵。

公开(公告)号：US20080240348A1

公开(公告)日：2008-10-02

申请号：US11995303

申请日：2006-07-11

申请人： Srijit Kamath ,  Sartaj Kumar Sahni ,  Jonathan Li ,  Jatinder Palta ,  Sanjay Ranka

发明人： Srijit Kamath ,  Sartaj Kumar Sahni ,  Jonathan Li ,  Jatinder Palta ,  Sanjay Ranka

IPC分类号： A61N5/10

CPC分类号： A61N5/1042 ,  A61N5/1036 ,  G21K1/04

摘要： A method and associated system 300 for delivering intensity-modulated radiation therapy (IMRT) uses variable feathering field splitting for intensity modulated fields of large size. Processor 112 controls a beam-shaping device 106 so that the beam-shaping device splits the radiation beam into a plurality of radiation fields delivered to the patient 102. Processor 112 in cooperation with beam-shaping device 106 implements a variable feathering method which includes the steps of providing an intensity matrix for the treatment of a patient, the intensity matrix having a plurality of rows and columns for spanning a prescribed radiation field including a prescribed field width. The prescribed width is compared to a maximum field width provided by the radiation treatment system. The intensity matrix is split into a plurality of spatially overlapping intensity submatrices when the prescribed width exceeds the maximum field width, wherein the splitting comprises variably feathering the intensity matrix. Radiotherapy is then provided to the patient 102 using a leaf sequencing method to generate the submatrices.

摘要翻译： 用于递送强度调制辐射治疗（IMRT）的方法和相关系统300使用大尺寸强度调制场的可变羽化场分割。 处理器112控制光束整形装置106，使得光束整形装置将辐射束分成传送到患者102的多个辐射场。 与光束整形装置106协作的处理器112实现可变羽化方法，其包括提供用于治疗患者的强度矩阵的步骤，所述强度矩阵具有多个行和列，用于跨越规定的辐射场，包括规定的 字段宽度。 将规定的宽度与辐射处理系统提供的最大场宽进行比较。 当规定的宽度超过最大场宽时，强度矩阵被分割成多个空间上重叠的强度子矩阵，其中分割包括可变地羽化强度矩阵。 然后使用叶片测序方法向患者102提供放射疗法以产生子矩阵。

公开(公告)号：US06449336B2

公开(公告)日：2002-09-10

申请号：US09859813

申请日：2001-05-18

申请人： Siyong Kim ,  Jatinder Palta

发明人： Siyong Kim ,  Jatinder Palta

IPC分类号： A61N510

CPC分类号： A61N5/1084 ,  A61N5/1042

摘要： A technique for Intensity-modulated radiation therapy (IMRT), an advanced form of external beam irradiation that is commonly referred as three-dimensional conformal radiation therapy (3DCRT), uses an array of radiation sources disposed within cells of a two-dimensional (2D) grid of radiation blocking walls. The intensity of radiation applied to a patient from any individual source is modulated dependent on local properties of a target, such as characteristics or dimensions of that portion of a tumor subject to radiation from a given source at a given time. In particular, each source is individually moved toward or away from the patient depending on the local (i.e., local to that source) properties of the target.