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    Fatty acid esters of glycolic acid and its salts
    4.
    发明授权
    Fatty acid esters of glycolic acid and its salts 失效
    乙醇酸及其盐的脂肪酸酯

    公开(公告)号：US5912009A

    公开(公告)日：1999-06-15

    申请号：US959944

    申请日：1997-10-29

    申请人： Srinivasan Venkateshwaran ,  David Fikstad ,  Sonal R. Patel

    发明人： Srinivasan Venkateshwaran ,  David Fikstad ,  Sonal R. Patel

    IPC分类号： A61F13/02 ,  A61K9/00 ,  A61K9/70 ,  A61K31/196 ,  A61K31/506 ,  A61K31/522 ,  A61K31/565 ,  A61K31/568 ,  A61K47/14

    CPC分类号： A61K9/7061 ,  A61K47/14 ,  A61K9/0014 ,  Y10S514/946 ,  Y10S514/947

    摘要： A transdermal drug delivery system which enhances the delivery of the drug comprises a composition containing, as an enhancer, one or more C.sub.6 to C.sub.22 fatty acid esters of glycolic acid and its salts. These compositions are made up of a safe and effective amount of an active pharmaceutical permeant contained in a penetration-enhancing vehicle comprising, 0.25 to 50% w. of the fatty acid glycolic acid ester enhancer in a suitable carrier vehicle. These fatty acid glycolic acid ester enhancers may be used in various carrier vehicles to enhance the transdermal delivery of active permeants in either free form or used in an occlusive device, particularly in a transdermal patch in matrix or reservoir form. When used in matrix patch form, the fatty acid glycolic acid ester enhancers and permeants are incorporated into a biocompatible adhesive. When used in a reservoir type patch, the permeant and fatty acid glycolic acid ester enhancers are incorporated into a carrier fluid of controlled viscosity such as a gel or ointment preferably containing a lower alkanol and water. In free form, the enhancer and permeant may be incorporated into an ointment, lotion, cream, or similar formulation.

    摘要翻译： 增强药物递送的透皮药物递送系统包含含有一种或多种乙醇酸及其盐的一种或多种C 6至C 22脂肪酸酯作为增强剂的组合物。 这些组合物由安全有效量的包含在穿透增强载体中的活性药物渗透剂组成，其包含0.25至50重量％的w。 的脂肪酸乙醇酸酯增强剂在合适的载体载体中。 这些脂肪酸乙醇酸酯增强剂可用于各种载体载体中，以增强游离形式的活性渗透物的透皮递送或用于闭塞装置，特别是基质或储液器形式的透皮贴剂。 当以基质斑块形式使用时，将脂肪酸乙醇酸酯增强剂和渗透剂掺入生物相容性粘合剂中。 当用于储层型贴片时，将渗透剂和脂肪酸乙醇酸酯增强剂掺入到受控粘度的载体流体中，例如优选含有低级链烷醇和水的凝胶或软膏剂。 以游离形式，增强剂和渗透剂可以掺入软膏，洗剂，霜剂或类似制剂中。

    Anti-inflammatory and analgesic compositions and related methods
    5.
    发明申请
    Anti-inflammatory and analgesic compositions and related methods 审中-公开
    抗炎镇痛成分及相关方法

    公开(公告)号：US20070281927A1

    公开(公告)日：2007-12-06

    申请号：US11448597

    申请日：2006-06-06

    申请人： Shanthakumar Tyavanagimatt ,  David Fikstad ,  Chandrashekar Giliyar ,  Mahesh Patel ,  Srinivasan Venkateshwaran

    发明人： Shanthakumar Tyavanagimatt ,  David Fikstad ,  Chandrashekar Giliyar ,  Mahesh Patel ,  Srinivasan Venkateshwaran

    IPC分类号： A61K31/5415

    CPC分类号： A61K31/5415 ,  A61K9/2054 ,  A61K9/4858 ,  A61K9/5084

    摘要： Methods and compositions for delivering a meloxicam compound are disclosed and described. In one aspect, a method may include perorally administering to a subject a therapeutically effective amount of a meloxicam compound that provides a meloxicam plasma concentration within 1 hour which is at least about 40% of the maximum plasma concentration attained by the formulation. In another aspect, a composition may include a therapeutically effective amount of a meloxicam compound in a pharmaceutically acceptable carrier including at least one of an alkalizer or a solubilizer, with the meloxicam compound having a solubility in the carrier that is greater than about 1.0 mg/gm.

    摘要翻译： 公开和描述了递送美洛昔康化合物的方法和组合物。 一方面，方法可以包括向受试者口服施用治疗有效量的美洛昔康化合物，所述美洛昔康化合物在1小时内提供美洛昔康血浆浓度，其为制剂达到的最大血浆浓度的至少约40％。 另一方面，组合物可以包括药学上可接受的载体中的治疗有效量的美洛昔康化合物，其包括碱化剂或增溶剂中的至少一种，其中美洛昔康化合物在载体中的溶解度大于约1.0mg / gm。