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公开(公告)号:US07632952B2
公开(公告)日:2009-12-15
申请号:US11536757
申请日:2006-09-29
申请人: Stéphanie Deprets , Anke Steinmetz , Odile Angouillant-Boniface , Daniel Bezard , Jidong Zhang , Yannick Benedetti , François Clerc
发明人: Stéphanie Deprets , Anke Steinmetz , Odile Angouillant-Boniface , Daniel Bezard , Jidong Zhang , Yannick Benedetti , François Clerc
IPC分类号: A61K31/428 , C07D277/82
CPC分类号: C07D417/12 , C07D277/82 , C07D417/14
摘要: The invention especially relates to novel chemical compounds, especially novel benzothiazole derivatives, to compositions containing said compounds, and to the use thereof as medicaments.
摘要翻译: 本发明特别涉及新型化合物,特别是新颖的苯并噻唑衍生物,含有所述化合物的组合物及其作为药物的用途。
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公开(公告)号:US20070093488A1
公开(公告)日:2007-04-26
申请号:US11536757
申请日:2006-09-29
申请人: Stephanie Deprets , Anke Steinmetz , Odile Angouillant-Boniface , Daniel Bezard , Jidong Zhang , Yannick Benedetti , Francois Clerc
发明人: Stephanie Deprets , Anke Steinmetz , Odile Angouillant-Boniface , Daniel Bezard , Jidong Zhang , Yannick Benedetti , Francois Clerc
IPC分类号: A61K31/53 , A61K31/517 , A61K31/506 , A61K31/4745 , A61K31/4439 , A61K31/4709 , A61K31/428 , C07D417/02
CPC分类号: C07D417/12 , C07D277/82 , C07D417/14
摘要: The invention especially relates to novel chemical compounds, especially novel benzothiazole derivatives, to compositions containing said compounds, and to the use thereof as medicaments.
摘要翻译: 本发明特别涉及新型化合物,特别是新颖的苯并噻唑衍生物,含有所述化合物的组合物及其作为药物的用途。
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3.Substituted indazoles, compositions containing them, method of production and use 有权
标题翻译: 取代的吲唑,含有它们的组合物,生产和使用方法公开(公告)号:US07473701B2
公开(公告)日:2009-01-06
申请号:US10963880
申请日:2004-10-13
申请人: Dominique Damour , Jean-Christophe Carry , Patrick Nemecek , Corinne Terrier , Frederico Nardi , Bruno Filoche-Romme , Marie-Pierre Cherrier , Daniel Bezard
发明人: Dominique Damour , Jean-Christophe Carry , Patrick Nemecek , Corinne Terrier , Frederico Nardi , Bruno Filoche-Romme , Marie-Pierre Cherrier , Daniel Bezard
IPC分类号: A61K31/415 , C07D231/54
CPC分类号: C07D231/56
摘要: Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting activity, having therapeutic activity, in particular in oncology.
摘要翻译: 取代的吲唑,含有它们的组合物,生产和使用方法。 本发明特别涉及具有激酶抑制活性的新型特异性取代的吲唑,具有治疗活性,特别是肿瘤学。
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公开(公告)号:US20050267304A1
公开(公告)日:2005-12-01
申请号:US10995103
申请日:2004-11-23
申请人: Paul Cox , Tahir Majid , Justine Lai , Andrew Morley , Shelley Amendola , Stephanie Deprets , Christopher Edlin , Charles Gardner , Dorothea Kominos , Brian Pedgrift , Frank Halley , Timothy Gillespy , Michael Edwards , Francois Clerc , Conception Nemecek , Olivier Houille , Dominique Damour , Herve Bouchard , Daniel Bezard , Chantal Carrez
发明人: Paul Cox , Tahir Majid , Justine Lai , Andrew Morley , Shelley Amendola , Stephanie Deprets , Christopher Edlin , Charles Gardner , Dorothea Kominos , Brian Pedgrift , Frank Halley , Timothy Gillespy , Michael Edwards , Francois Clerc , Conception Nemecek , Olivier Houille , Dominique Damour , Herve Bouchard , Daniel Bezard , Chantal Carrez
IPC分类号: A61K20060101 , A61K31/437 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61P20060101 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D20060101 , C07D209/00 , C07D221/00 , C07D241/00 , C07D471/04 , C07D487/04 , C07D519/00 , C07D487/02 , A61K31/4745 , A61K31/498 , C07D471/02
CPC分类号: C07D519/00 , C07D471/04 , C07D487/04
摘要: The invention is directed to physiologically active compounds of general formula (I):— and compositions containing such compounds; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.
摘要翻译: 本发明涉及通式(I)的生理活性化合物: - 和含有这些化合物的组合物; 及其前药,以及这些化合物及其前药的药学上可接受的盐和溶剂合物,以及式(I)范围内的新化合物。 这些化合物和组合物具有有价值的药物特性,特别是抑制激酶的能力。
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5.Substituted indazoles, compositions containing them, method of production and use 有权
标题翻译: 取代的吲唑,含有它们的组合物,生产和使用方法公开(公告)号:US20050059722A1
公开(公告)日:2005-03-17
申请号:US10963880
申请日:2004-10-13
申请人: Dominique Damour , Jean-Christophe Carry , Patrick Nemecek , Corinne Terrier , Frederico Nardi , Bruno Filoche , Marie-Pierre Cherrier , Daniel Bezard
发明人: Dominique Damour , Jean-Christophe Carry , Patrick Nemecek , Corinne Terrier , Frederico Nardi , Bruno Filoche , Marie-Pierre Cherrier , Daniel Bezard
IPC分类号: A61K31/416 , A61K31/4184 , A61K31/42 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/695 , A61P35/00 , A61P43/00 , C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07F7/10 , C07D43/02
CPC分类号: C07D231/56
摘要: Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting activity, having therapeutic activity, in particular in oncology.
摘要翻译: 取代的吲唑,含有它们的组合物,生产和使用方法。 本发明特别涉及具有激酶抑制活性的新型特异性取代的吲唑,具有治疗活性,特别是肿瘤学。
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6.Substituted indazoles, compositions containing them, method of production and use 有权
标题翻译: 取代的吲唑,含有它们的组合物,生产和使用方法公开(公告)号:US06858638B2
公开(公告)日:2005-02-22
申请号:US10385870
申请日:2003-03-11
申请人: Dominique Damour , Jean-Christophe Carry , Patrick Nemecek , Corinne Terrier , Frederico Nardi , Bruno Filoche , Marie-Pierre Cherrier , Daniel Bezard
发明人: Dominique Damour , Jean-Christophe Carry , Patrick Nemecek , Corinne Terrier , Frederico Nardi , Bruno Filoche , Marie-Pierre Cherrier , Daniel Bezard
IPC分类号: A61K31/416 , A61K31/4184 , A61K31/42 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/695 , A61P35/00 , A61P43/00 , C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07F7/10
CPC分类号: C07D231/56
摘要: Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting activity, having therapeutic activity, in particlar in oncology.
摘要翻译: 取代的吲唑,含有它们的组合物,生产和使用方法。 本发明特别涉及具有激酶抑制活性的新型特异性取代吲唑,具有治疗活性,特别是肿瘤学。
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