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    2-aminothiazoline derivatives and process for preparing the same
    4.
    发明授权
    2-aminothiazoline derivatives and process for preparing the same 失效
    2-氨基噻唑啉衍生物及其制备方法

    公开(公告)号：US06699895B2

    公开(公告)日：2004-03-02

    申请号：US10159498

    申请日：2002-05-31

    申请人： Jean-Christophe Carry ,  Dominique Damour ,  Claude Guyon ,  Serge Mignani ,  Antony Bigot ,  Eric Bacque ,  Michel Tabart

    发明人： Jean-Christophe Carry ,  Dominique Damour ,  Claude Guyon ,  Serge Mignani ,  Antony Bigot ,  Eric Bacque ,  Michel Tabart

    IPC分类号： C07D41706

    CPC分类号： C07D417/06 ,  A61K31/426 ,  A61K31/4439 ,  C07D277/18

    摘要： The present invention relates to a class of 2-aminothiazoline derivatives of formula I: in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, —CH2—R3, —CH2—S—R4 or phenyl radical substituted with a nitro or —NH—C(═NH)CH3 radical, or R1 is an alkyl radical and R2 is a hydrogen atom, R3 is a (3-6C) cycloalkyl, pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl or phenyl radical or a phenyl radical substituted with a nitro, hydroxy or carboxyl radical, R4 represents a pyridyl or pyridyl N-oxide radical, alk represents an alkylene radical, or pharmaceutically acceptable salts thereof, which are useful as inhibitors of inducible NO-synthase.

    摘要翻译： 本发明涉及一类式I的2-氨基噻唑啉衍生物：其中R1是氢原子或烷基，R2是烷基，-alk-NH2，-CH2-R3，-CH2-S-R4 或被硝基或-NH-C（= NH）CH 3基团取代的苯基，或R 1是烷基，R 2是氢原子，R 3是（3-6C）环烷基，吡啶基，吡啶基N-氧化物，噻吩基 ，噻唑基，咪唑基，吡嗪基，三唑基或苯基或被硝基，羟基或羧基取代的苯基，R4表示吡啶基或吡啶基N-氧化物基，alk表示亚烷基或其药学上可接受的盐，它们是 可用作诱导型NO合成酶的抑制剂。

    Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase
    5.
    发明授权
    Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase 失效
    使用2-氨基噻唑啉衍生物作为诱导型无合成酶的抑制剂

    公开(公告)号：US06451821B1

    公开(公告)日：2002-09-17

    申请号：US09878814

    申请日：2001-06-08

    申请人： Jean-Christophe Carry ,  Dominique Damour ,  Claude Guyon ,  Serge Mignani ,  Antony Bigot ,  Eric Bacque ,  Michel Tabart

    发明人： Jean-Christophe Carry ,  Dominique Damour ,  Claude Guyon ,  Serge Mignani ,  Antony Bigot ,  Eric Bacque ,  Michel Tabart

    IPC分类号： A61K3144

    CPC分类号： C07D417/06 ,  A61K31/426 ,  A61K31/4439 ,  C07D277/18

    摘要： The present invention relates to the use of 2-aminothiazoline derivatives of formula: in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk—NH2, —CH2—R3, —CH2—S—R4 or phenyl radical substituted with a nitro or —NH— C (═NH) CH3 radical, or R1 is an alkyl radical and R2 is a hydrogen atom, R3 is a (3-6C) cycloalkyl, pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl or phenyl radical or a phenyl radical substituted with a nitro, hydroxy or carboxyl radical, R4 represents a pyridyl or pyridyl N-oxide radical, alk represents an alkylene radical, or pharmaceutically acceptable salts thereof, as inhibitors of inducible NO-synthase.

    摘要翻译： 本发明涉及下式的2-氨基噻唑啉衍生物的用途：其中R1是氢原子或烷基，R2是烷基，-alk-NH2，-CH2-R3，-CH2-S-R4或 被硝基或-NH- C（= NH）CH 3基取代的苯基，或R 1是烷基，R 2是氢原子，R 3是（3-6C）环烷基，吡啶基，吡啶基N-氧化物，噻吩基， 噻唑基，咪唑基，吡嗪基，三唑基或苯基或被硝基，羟基或羧基取代的苯基，R4表示吡啶基或吡啶基N-氧化物基，alk表示亚烷基或其药学上可接受的盐，作为 诱导型NO合成酶。