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1.发明授权Use of the M3 protein of MHV68 to block binding of a chemokine to its receptor 失效使用MHV68的M3蛋白阻断趋化因子与其受体的结合公开(公告)号：US06843991B1
公开(公告)日：2005-01-18
申请号：US09617178
申请日：2000-07-17
申请人： Stacey Efstathiou , Antonio Alcami , Christopher Marc Parry , Vincent Peter Smith , João Pedro Monteiro e Louro Machado de Simas
发明人： Stacey Efstathiou , Antonio Alcami , Christopher Marc Parry , Vincent Peter Smith , João Pedro Monteiro e Louro Machado de Simas
IPC分类号： G01N33/53 , A61K35/76 , A61K38/00 , A61K45/00 , A61K48/00 , A61P31/12 , A61P33/00 , A61P37/02 , C07K14/03 , C12N15/09 , G01N33/566 , G01N33/68 , A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/14143 , C12N2710/16022 , G01N33/6863 , Y10S530/826
摘要： A pharmaceutical composition comprises M3 protein as encoded by virus MHV 68, or a homologue of said M3 protein, for use in binding to a chemokine or a chemokine analogue in vivo, or to block binding of chemokines to corresponding cell surface receptors in vivo, to produce an immunomodulatory effect, or to bind to a chemokine analogue present in a virus or parasite to block its entry into cells.
摘要翻译： 药物组合物包含由病毒MHV68编码的M3蛋白或所述M3蛋白的同源物，用于在体内与趋化因子或趋化因子类似物结合，或阻断趋化因子与体内相应细胞表面受体的结合，至 产生免疫调节作用或与病毒或寄生虫中存在的趋化因子类似物结合以阻止其进入细胞。
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公开(公告)号：US08192930B2
公开(公告)日：2012-06-05
申请号：US12223759
申请日：2007-02-08
申请人： Eric Hans Vermaas , Graham John Worsley , Jonathan Mark Boutell , Colin Lloyd Barnes , Roberto Rigatti , Niall Anthony Gormley , Geoffrey Paul Smith , Vincent Peter Smith , Tobias William Barr Ost , David Bentley
发明人： Eric Hans Vermaas , Graham John Worsley , Jonathan Mark Boutell , Colin Lloyd Barnes , Roberto Rigatti , Niall Anthony Gormley , Geoffrey Paul Smith , Vincent Peter Smith , Tobias William Barr Ost , David Bentley
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6869 , C12Q2565/518 , C12Q2537/149
摘要： The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.
摘要翻译： 本发明提供了双链多核苷酸模板的成对测序的方法，该方法导致多核苷酸模板的两个不同和分离的区域中的核苷酸序列的顺序测定。
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公开(公告)号：US20110009276A1
公开(公告)日：2011-01-13
申请号：US12223759
申请日：2007-02-08
申请人： Eric Hans Vermaas , Graham John Worsley , Jonathan Mark Boutell , Colin Lloyd Barnes , Roberto Rigatti , Niall Anthony Gormley , Geoffrey Paul Smith , Vincent Peter Smith , Tobias Willaim Barr Ost , David Bentley
发明人： Eric Hans Vermaas , Graham John Worsley , Jonathan Mark Boutell , Colin Lloyd Barnes , Roberto Rigatti , Niall Anthony Gormley , Geoffrey Paul Smith , Vincent Peter Smith , Tobias Willaim Barr Ost , David Bentley
IPC分类号： C40B30/00
CPC分类号： C12Q1/6874 , C12Q1/6869 , C12Q2565/518 , C12Q2537/149
摘要： The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.
摘要翻译： 本发明提供了双链多核苷酸模板的成对测序的方法，该方法导致多核苷酸模板的两个不同和分离的区域中的核苷酸序列的顺序测定。
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公开(公告)号：US08945835B2
公开(公告)日：2015-02-03
申请号：US13444654
申请日：2012-04-11
申请人： Eric Hans Vermaas , Graham John Worsley , Jonathan Mark Boutell , Colin Lloyd Barnes , Roberto Rigatti , Niall Anthony Gormley , Geoffrey Paul Smith , Vincent Peter Smith , Tobias William Barr Ost , David Bentley
发明人： Eric Hans Vermaas , Graham John Worsley , Jonathan Mark Boutell , Colin Lloyd Barnes , Roberto Rigatti , Niall Anthony Gormley , Geoffrey Paul Smith , Vincent Peter Smith , Tobias William Barr Ost , David Bentley
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6869 , C12Q2565/518 , C12Q2537/149
摘要： The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.
摘要翻译： 本发明提供了双链多核苷酸模板的成对测序的方法，该方法导致多核苷酸模板的两个不同和分离的区域中的核苷酸序列的顺序测定。
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公开(公告)号：US20130165327A1
公开(公告)日：2013-06-27
申请号：US13444654
申请日：2012-04-11
申请人： Eric Hans Vermaas , Graham John Worsley , Jonathan Mark Boutell , Colin Lloyd Barnes , Roberto Rigatti , Niall Anthony Gormley , Geoffrey Paul Smith , Vincent Peter Smith , Tobias William Barr Ost , David Bentley
发明人： Eric Hans Vermaas , Graham John Worsley , Jonathan Mark Boutell , Colin Lloyd Barnes , Roberto Rigatti , Niall Anthony Gormley , Geoffrey Paul Smith , Vincent Peter Smith , Tobias William Barr Ost , David Bentley
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6869 , C12Q2565/518 , C12Q2537/149
摘要： The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.
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