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公开(公告)号：US20210401923A1
公开(公告)日：2021-12-30
申请号：US17371475
申请日：2021-07-09
发明人： D. Travis Wilson , Mark Bamberger
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
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公开(公告)号：US11141456B2
公开(公告)日：2021-10-12
申请号：US16746745
申请日：2020-01-17
发明人： D. Travis Wilson
IPC分类号： A61K38/10 , A61K38/06 , A61K38/08 , A61K38/07 , C07K5/078 , C07K5/09 , C07K5/087 , C07K5/107 , C07K5/065 , C07K5/113 , C07K5/072 , C07K5/097 , A61K47/64 , A61K38/05 , A61K38/13 , A61K38/17 , A61K38/40 , A61K38/44 , A61K38/45 , A61K38/46 , A61K38/51 , A61K38/53
摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2′,6′-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, or D-Arg-2′,6′-Dmt-Lys-Phe-NH2.
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公开(公告)号：US11083771B2
公开(公告)日：2021-08-10
申请号：US15626255
申请日：2017-06-19
发明人： D. Travis Wilson , Mark Bamberger
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
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公开(公告)号：US20210025873A1
公开(公告)日：2021-01-28
申请号：US16845687
申请日：2020-04-10
发明人： D. Travis Wilson
IPC分类号： G01N33/50
摘要： The present technology provides methods for detecting and diagnosing diseases and conditions characterized by mitochondrial dysfunction using monocytes as an indicator of the dysfunction.
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公开(公告)号：US20200345803A1
公开(公告)日：2020-11-05
申请号：US16929370
申请日：2020-07-15
发明人： D. Travis Wilson , Mark Bamberger
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
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公开(公告)号：US20200223887A1
公开(公告)日：2020-07-16
申请号：US16724037
申请日：2019-12-20
摘要： The present disclosure provides methods of preventing or treating renal ischemia-reperfusion injury in a mammalian subject and methods for chronic treatment of ARVD, including administering an effective amount of an aromatic-cationic peptide to a subject in need thereof. The methods include administering aromatic-cationic peptides to prevent or treat renal injury during the treatment of renal artery stenosis. The methods include administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
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公开(公告)号：US10646539B2
公开(公告)日：2020-05-12
申请号：US16390799
申请日：2019-04-22
发明人： D. Travis Wilson
IPC分类号： A61K38/07 , A61K38/08 , A61K33/243 , A61K31/137 , A61K31/185 , A61K31/337 , A61K31/366 , A61K31/4245 , A61K31/4748 , A61K31/55 , A61K31/7042
摘要： The disclosure relates to methods for treating a subject suffering from hyperalgesia caused by drug-induced neuropathy by administering to the subject an effective amount of an aromatic-cationic peptide. The disclosure also relates to methods for protecting a subject from hyperalgesia caused by drug-induced neuropathy by administering an effective amount of an aromatic-cationic peptide to a subject at risk for developing the condition.
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公开(公告)号：US20190388493A1
公开(公告)日：2019-12-26
申请号：US16425892
申请日：2019-05-29
发明人： D. Travis Wilson
IPC分类号： A61K38/07 , A61K45/06 , A61K38/28 , A61K31/122 , A61K31/401 , A61K31/4412 , A61K31/7048 , C07K5/11
摘要： The disclosure provides methods of preventing or treating Friedreich's ataxia in a mammalian subject, reducing risk factors, signs and/or symptoms associated with Friedreich's ataxia, and/or reducing the likelihood or severity of Friedreich's ataxia. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to e.g., reduce oxidative stress, increase mitochondrial metabolism, or a combination thereof.
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公开(公告)号：US10279008B2
公开(公告)日：2019-05-07
申请号：US15488697
申请日：2017-04-17
发明人： D. Travis Wilson
摘要： The disclosure relates to methods for treating a subject suffering from hyperalgesia caused by drug-induced neuropathy by administering to the subject an effective amount of an aromatic-cationic peptide. The disclosure also relates to methods for protecting a subject from hyperalgesia caused by drug-induced neuropathy by administering an effective amount of an aromatic-cationic peptide to a subject at risk for developing the condition.
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公开(公告)号：US20180147251A1
公开(公告)日：2018-05-31
申请号：US15626255
申请日：2017-06-19
发明人： D. Travis Wilson , Mark Bamberger
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
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