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公开(公告)号：US10188693B2
公开(公告)日：2019-01-29
申请号：US14418827
申请日：2013-07-31
IPC分类号： A61K31/22 , A61K31/40 , A61K38/08 , A61K45/06 , A61K38/07 , A61K31/366 , A61K31/404 , A61K31/505 , A61K31/215 , A61K31/351 , A61P9/10
摘要： Disclosed herein are methods and compositions for preventing or treating atherosclerosis in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide and in some applications, a second active agent chemically linked to the peptide, to subjects in need thereof.
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公开(公告)号：US20180344797A1
公开(公告)日：2018-12-06
申请号：US15848198
申请日：2017-12-20
发明人： D. Travis Wilson , Mark Bamberger , Brian Blakey
IPC分类号： A61K38/07 , A61P9/10 , A61K31/215 , A61K31/351 , A61K45/06 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/505
CPC分类号： A61K38/07 , A61K31/215 , A61K31/22 , A61K31/351 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/505 , A61K45/06 , A61P9/10 , A61K2300/00
摘要： Disclosed herein are methods and compositions for preventing or treating atherosclerosis in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide and, in some applications, a second active agent, to subjects in need thereof. The present technology relates to the treatment or prevention of atherosclerosis in mammals through the administration of a therapeutically effective amount of aromatic cationic peptides and, in some embodiments, a second active agent.
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公开(公告)号：US20180339012A1
公开(公告)日：2018-11-29
申请号：US15848712
申请日：2017-12-20
IPC分类号： A61K38/07 , A61P9/10 , A61K31/215 , A61K31/351 , A61K45/06 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/505
摘要： Disclosed herein are methods and compositions for preventing or treating atherosclerosis in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide and in some applications, a second active agent chemically linked to the peptide, to subjects in need thereof.
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公开(公告)号：US09687519B2
公开(公告)日：2017-06-27
申请号：US14771408
申请日：2014-02-28
发明人： D. Travis Wilson , Mark Bamberger
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
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公开(公告)号：US20170182117A1
公开(公告)日：2017-06-29
申请号：US15313833
申请日：2015-05-27
发明人： D. Travis Wilson , Mark Bamberger , Peter Oates
IPC分类号： A61K38/10 , A61K31/198 , A61K31/205 , A61K31/51 , A61K31/525 , A61K31/455 , A61K31/675 , A61K31/714 , A61K31/519 , A61K31/375 , A61K31/355 , A61K31/385 , A61K31/194 , A61K38/07 , A61K38/08 , A61K38/06 , A61K38/05 , A61K45/06 , A61K38/13 , A61K31/122
CPC分类号： A61K38/10 , A01N1/0226 , A61K31/122 , A61K31/194 , A61K31/198 , A61K31/205 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/675 , A61K31/714 , A61K38/04 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/13 , A61K45/06 , A61K47/645 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/1008 , C07K5/1016 , C07K5/1019 , C07K5/1024 , A61K2300/00
摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of TSM, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to TSM and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2′,6′-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, or D-Arg-2′,6′-Dmt-Lys-Phe-NH2.
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公开(公告)号：US20210401923A1
公开(公告)日：2021-12-30
申请号：US17371475
申请日：2021-07-09
发明人： D. Travis Wilson , Mark Bamberger
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
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公开(公告)号：US20210330735A1
公开(公告)日：2021-10-28
申请号：US17260718
申请日：2019-07-15
发明人： Mark Bamberger , David T. Tse , Daniel Pelaez
IPC分类号： A61K38/07 , A61K38/17 , A61K45/06 , A61K31/4178 , A61K31/05 , A61K31/4409 , A61P27/02
摘要： The present disclosure provides novel methods for treating or preventing traumatic optic neuropathy (TON), methods for improving visual function in a subject having TON, methods for promoting retinal ganglion cell (RGC) survival or increasing neurite outgrowth of an RGC, and methods for reducing the risk of having or developing TON in a subject that has experienced a traumatic injury. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide.
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公开(公告)号：US11083771B2
公开(公告)日：2021-08-10
申请号：US15626255
申请日：2017-06-19
发明人： D. Travis Wilson , Mark Bamberger
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
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公开(公告)号：US20200345803A1
公开(公告)日：2020-11-05
申请号：US16929370
申请日：2020-07-15
发明人： D. Travis Wilson , Mark Bamberger
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
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公开(公告)号：US20180147251A1
公开(公告)日：2018-05-31
申请号：US15626255
申请日：2017-06-19
发明人： D. Travis Wilson , Mark Bamberger
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
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