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    Macroporous material in the form of plastic pearls
    1.
    发明授权
    Macroporous material in the form of plastic pearls 失效
    大孔材料以塑料珠的形式

    公开(公告)号：US07381552B2

    公开(公告)日：2008-06-03

    申请号：US10498971

    申请日：2003-08-25

    申请人： Stefan Menzler ,  Hans-Ulrich Petereit ,  Christian Meier ,  Thomas Boller ,  Thomas Suefke ,  Klaus Schultes ,  Roger Recktenwald

    发明人： Stefan Menzler ,  Hans-Ulrich Petereit ,  Christian Meier ,  Thomas Boller ,  Thomas Suefke ,  Klaus Schultes ,  Roger Recktenwald

    IPC分类号： C12N11/08 ,  G01N33/545 ,  C07K17/08

    CPC分类号： C08F220/28 ,  C08F246/00 ,  Y10S530/815

    摘要： The invention relates to a macroporous plastics bead material with an average particle diameter from 10 to 1000 μm, containing a copolymer of a) 5-60 wt. % vinylically polymerizable monomers with a water solubility of at least 1% at 20° C., b) 1-40 wt. % vinylically polymerizable monomers with an additional functional group, which can enter into covalent bonds with the nucleophilic groups of the ligands in a polymer-like reaction, c) 10-40 wt. % hydrophilic, crosslinking radical-polymerizable monomers with two or more ethylenically unsaturated polymerizable groups and d) 10-60 wt. % vinylically polymerizable monomers with a water solubility of at most 1% at 20° C. are contained, as a rule with the monomers a) to d) adding up to 100%.

    摘要翻译： 本发明涉及平均粒径为10-1000μm的大孔塑料珠粒材料，其含有a）5-60wt。 ％乙烯基聚合性单体，水溶性在20℃下至少为1％，b）1-40wt。 具有另外的官能团的具有可与聚合物样反应中的配体的亲核基团共价键的乙烯基聚合性单体的％，c）10-40wt。 具有两个或更多个烯属不饱和可聚合基团的亲水性交联自由基聚合单体，和d）10-60wt。 在20℃下水溶解度最多为1％的％乙烯基聚合性单体的含量通常与单体a）至d）相加至100％。

    Macroporous material in the form of plastic pearls
    4.
    发明申请
    Macroporous material in the form of plastic pearls 失效
    大孔材料以塑料珍珠的形式

    公开(公告)号：US20050065224A1

    公开(公告)日：2005-03-24

    申请号：US10498971

    申请日：2003-08-25

    申请人： Stefan Menzler ,  Hans-Ulrich Petereit ,  Christian Meier ,  Thomas Boller ,  Thomas Suefke ,  Klaus Schultes ,  Roger Recktenwald

    发明人： Stefan Menzler ,  Hans-Ulrich Petereit ,  Christian Meier ,  Thomas Boller ,  Thomas Suefke ,  Klaus Schultes ,  Roger Recktenwald

    IPC分类号： C08F220/28 ,  C08F246/00 ,  C08J9/00 ,  C08F118/02

    CPC分类号： C08F220/28 ,  C08F246/00 ,  Y10S530/815

    摘要： The invention relates to a macroporous plastics bead material with an average particle diameter from 10 to 1000 μm, containing a copolymer of a) 5-60 wt. % vinylically polymerizable monomers with a water solubility of at least 1% at 20° C., b) 1-40 wt. % vinylically polymerizable monomers with an additional functional group, which can enter into covalent bonds with the nucleophilic groups of the ligands in a polymer-like reaction, c) 10-40 wt. % hydrophilic, crosslinking radical-polymerizable monomers with two or more ethylenically unsaturated polymerizable groups and d) 10-60 wt. % vinylically polymerizable monomers with a water solubility of at most 1% at 20° C. are contained, as a rule with the monomers a) to d) adding up to 100%.

    摘要翻译： 本发明涉及平均粒径为10-1000μm的大孔塑料珠粒材料，其含有a）5-60wt。 ％乙烯基聚合性单体，水溶性在20℃下至少为1％，b）1-40wt。 具有另外的官能团的具有可与聚合物样反应中的配体的亲核基团共价键的乙烯基聚合性单体的％，c）10-40wt。 具有两个或更多个烯属不饱和可聚合基团的亲水性交联自由基聚合单体，和d）10-60wt。 在20℃下水溶解度最多为1％的％乙烯基聚合性单体的含量通常与单体a）至d）相加至100％。

    Coating and binding agent for pharmaceutical formulations with improved storage stability
    7.
    发明授权
    Coating and binding agent for pharmaceutical formulations with improved storage stability 有权
    具有改善储存稳定性的药物制剂的涂层和粘合剂

    公开(公告)号：US07160558B2

    公开(公告)日：2007-01-09

    申请号：US10239634

    申请日：2001-02-27

    申请人： Hans-Ulrich Petereit ,  Christian Meier ,  Erna Roth

    发明人： Hans-Ulrich Petereit ,  Christian Meier ,  Erna Roth

    IPC分类号： A61K9/14 ,  A61K9/16

    CPC分类号： A61K9/282 ,  A61K9/2846 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

    摘要： The invention relates to a process for the preparation of a coating and binding agent for oral or dermal pharmaceutical forms, essentially consisting of (a) a copolymer consisting of free-radical-polymerized C1 to C4 esters of acrylic or methacrylic acid and further (meth)acrylate monomers which contain functional tertiary ammonium groups, the coplymer being present in powdered form having an average particle size of 1–40 μm, (b) 3 to 15% by weight, based on (a), of an emulsifier having an HLB of at least 14 and (c) 5 to 50% by weight, based on (a), of a C12—to C18-monocarboxylic acid or a C12—to C18-hydroxyl compound, the components (a), (b) and (c) being blended or mixed with one another with or without addition of water and if appropriate with addition of a pharmaceutical active compound and further customary additives and the coating and binding agent being produced from the mixture by melting, casting, spreading or spraying. The invention further relates to the coating and binding agent itself.

    摘要翻译： 本发明涉及一种制备用于口服或皮肤药物形式的包衣和粘合剂的方法，其基本上由（a）由丙烯酸或甲基丙烯酸的自由基聚合的C1至C4酯和（甲基）丙烯酸酯组成的共聚物 ）丙烯酸酯单体，所述共聚物以平均粒径为1-40μm的粉末形式存在，（b）基于（a）的3至15重量％的具有HLB的乳化剂 至少14和（c）5至50重量％，基于（a）的C 12 - C 18 C 18 - 单羧酸或C < 将组分（a），（b）和（c）在或不加入水中彼此混合或混合，如果 适当地添加药物活性化合物和进一步的常规添加剂，并且通过熔融，浇铸，铺展或喷涂由混合物制备涂层和粘合剂。 本发明还涉及涂层和粘合剂本身。

    Method for producing coated pharmaceuticals and food supplements with concentration gradients in the coating thereof
    9.
    发明申请
    Method for producing coated pharmaceuticals and food supplements with concentration gradients in the coating thereof 审中-公开
    用于在其涂层中生产具有浓度梯度的包衣药物和食品添加剂的方法

    公开(公告)号：US20050271778A1

    公开(公告)日：2005-12-08

    申请号：US10539614

    申请日：2003-10-18

    申请人： Hans-Ulrich Petereit ,  Christian Meier ,  Erna Roth

    发明人： Hans-Ulrich Petereit ,  Christian Meier ,  Erna Roth

    IPC分类号： A23L1/275 ,  A23L1/308 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A23B4/00

    CPC分类号： A61K9/4891 ,  A23L5/42 ,  A23L33/24 ,  A23L33/25 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/2893 ,  A61K9/5026 ,  A61K9/5047 ,  A61K9/5089

    摘要： The invention relates to a method for producing pharmaceuticals or parts thereof or food supplements or parts thereof, by coating substrates for pharmaceutical uses or for using as food supplements for humans or animals, with a film-forming coating agent mixed with at least one other substance suitable for the cited purposes. The film-forming coating agent and the other substance first constitute separate liquid, sprayable individual portions, and are sprayed by means of at least one spray device which are provided, individually or together, with at least two separate nozzles for liquids, and have overlapping spray jets—in such a way that the individual portions sprayed out of the separate nozzles mix during the spraying process and the mixture forms a continuous film coating on the substrate, forming the food supplement, the pharmaceutical or the part thereof. The invention is characterized in that the coating agent and the other substance are in a concentration gradient from the inside to the outside.

    摘要翻译： 本发明涉及一种制备药物或其部分或食品添加剂或其部分的方法，其通过将药物用途的基质或用作人或动物的食品添加剂，与至少一种其它物质混合的成膜包衣剂 适合引用的用途。 成膜涂层剂和其它物质首先构成单独的液体，可喷雾的单独部分，并且通过至少一个喷射装置喷射，所述喷射装置单独地或一起设置有用于液体的至少两个单独的喷嘴，并且具有重叠 喷射喷嘴 - 以这样的方式，使喷射出单独喷嘴的各个部分在喷涂过程中混合，并且混合物在基材上形成连续的膜涂层，形成食品补充剂，药物或其部分。 本发明的特征在于涂层剂和其它物质的浓度梯度是从内向外。

    Method for producing an immediately decomposing oral form of administration which releases active ingredients
    10.
    发明授权
    Method for producing an immediately decomposing oral form of administration which releases active ingredients 有权

    公开(公告)号：US08343542B2

    公开(公告)日：2013-01-01

    申请号：US10542283

    申请日：2003-11-21

    申请人： Hans-Ulrich Petereit ,  Christian Meier ,  Andreas Gryczke

    发明人： Hans-Ulrich Petereit ,  Christian Meier ,  Andreas Gryczke

    IPC分类号： A61K9/20 ,  B27N3/00

    CPC分类号： A61J3/10 ,  A61K9/0056 ,  A61K9/146 ,  A61K9/1647 ,  A61K9/2054 ,  A61K31/192

    摘要： The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth. According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerized C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass; the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 μm or less; and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein. The invention also relates to the powder containing active ingredients and the uses of the same.