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    Substituted 2-pyridone derivatives, method for their preparation and their use as medicament
    2.
    发明授权
    Substituted 2-pyridone derivatives, method for their preparation and their use as medicament 失效
    取代的2-吡啶酮衍生物，其制备方法及其用作药物

    公开(公告)号：US07863280B2

    公开(公告)日：2011-01-04

    申请号：US11733833

    申请日：2007-04-11

    申请人： Stefan Peukert ,  Stefan Guessregen ,  Armin Hofmeister ,  Herman Schreuder ,  Uwe Schwahn

    发明人： Stefan Peukert ,  Stefan Guessregen ,  Armin Hofmeister ,  Herman Schreuder ,  Uwe Schwahn

    IPC分类号： C07D401/02 ,  A61K31/44

    CPC分类号： C07D213/69 ,  C07D213/74 ,  C07D213/76 ,  C07D213/85 ,  C07D401/12

    摘要： This invention relates to compounds of formula (I), wherein R1 and R3 independently represent fluorine, methoxy, —OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; R2 represents hydrogen, fluorine, methoxy, —OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; X represents O, S, NH or N(C1-C3-alkyl); and Ar represents an unsubstituted or at least monosubstituted aryl or heteroaryl. Said compounds are inhibitors of poly(ADP-ribose) polymerase (PARP), and may be used for the treatment of a variety of disorders.

    摘要翻译： 本发明涉及式（I）化合物，其中R 1和R 3独立地表示氟，甲氧基，-OCF 3，C 2 -C 3 - 烯基或任选被氯，甲氧基或一个，二或三个氟取代的C 1 -C 4烷基 原子 R 2表示氢，氟，甲氧基，-OCF 3，C 2 -C 3 - 烯基或任选被氯，甲氧基或一个，两个或三个氟原子取代的C 1 -C 4烷基; X表示O，S，NH或N（C 1 -C 3 - 烷基）; 并且Ar表示未取代或至少单取代的芳基或杂芳基。 所述化合物是聚（ADP-核糖）聚合酶（PARP）的抑制剂，可用于治疗多种疾病。