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公开(公告)号：US20080294035A1
公开(公告)日：2008-11-27
申请号：US12124681
申请日：2008-05-21
CPC分类号： A61B5/055 , A61B5/0515 , G06T7/60
摘要： A system and method of evaluating the effectiveness of antiangionetic therapy is described. A patient or test animal is treated with an antiangionetic substance. Magnetic resonance imaging data is obtained prior to and subsequent to the treatment. The parameters of the imaging process are configured so that, by administering a intravascular contrast agent, the relative size of the microvascular and the total vascular volumes in a region of interest may be obtained, so as to form a vascular size index. The value of the vascular size index and other pharmacokinetic data obtained by the administration of a diffusible contrast agent are used to assess the efficacy of the treatment or the antiangionetic substance being studied.
摘要翻译： 描述了评估抗血管治疗疗效的系统和方法。 患者或测试动物用抗血友病药物治疗。 在治疗之前和之后获得磁共振成像数据。 成像过程的参数被配置为使得通过施用血管内造影剂可以获得感兴趣区域中的微血管的相对大小和总血管体积，从而形成血管尺寸指数。 使用通过施用可扩散造影剂获得的血管尺寸指数和其他药代动力学数据的值来评估所研究的治疗或抗血小球药物的功效。
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公开(公告)号：US08195275B2
公开(公告)日：2012-06-05
申请号：US12124681
申请日：2008-05-21
CPC分类号： A61B5/055 , A61B5/0515 , G06T7/60
摘要： A system and method of evaluating the effectiveness of antiangionetic therapy is described. A patient or test animal is treated with an antiangionetic substance. Magnetic resonance imaging data is obtained prior to and subsequent to the treatment. The parameters of the imaging process are configured so that, by administering a intravascular contrast agent, the relative size of the microvascular and the total vascular volumes in a region of interest may be obtained, so as to form a vascular size index. The value of the vascular size index and other pharmacokinetic data obtained by the administration of a diffusible contrast agent are used to assess the efficacy of the treatment or the antiangionetic substance being studied.
摘要翻译： 描述了评估抗血管治疗疗效的系统和方法。 患者或测试动物用抗血友病药物治疗。 在治疗之前和之后获得磁共振成像数据。 成像过程的参数被配置为使得通过施用血管内造影剂可以获得感兴趣区域中的微血管的相对大小和总血管体积，从而形成血管尺寸指数。 使用通过施用可扩散造影剂获得的血管尺寸指数和其他药代动力学数据的值来评估所研究的治疗或抗血小球药物的功效。
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3.发明申请公开(公告)号：US20090062630A1
公开(公告)日：2009-03-05
申请号：US12222776
申请日：2008-08-15
申请人： Arne Hengerer , Robert Krieg , Sebastian Schmidt , Ralph Strecker
发明人： Arne Hengerer , Robert Krieg , Sebastian Schmidt , Ralph Strecker
CPC分类号： A61B5/415 , A61B5/05 , A61B5/06 , A61B5/418 , A61K49/16 , A61K49/18 , A61K49/1875 , B82Y5/00 , G01R33/50 , G01R33/5601
摘要： A sensor is disclosed for permitting detection of a substance in the body of a living being. In at least one embodiment, the sensor includes probe molecules, for binding the substance that is to be detected, and marking elements designed in such a way that the binding of the probe molecules to the substance to be detected is detectable by way of an imaging modality. For example, antigens or pathogens that are present only in a low concentration can be detected.
摘要翻译： 公开了用于允许检测生物体内物质的传感器。 在至少一个实施例中，传感器包括用于结合要检测的物质的探针分子和以使得探针分子与待检测物质的结合可通过成像检测的方式设计的标记元件 模态 例如，可以检测出仅存在低浓度的抗原或病原体。
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4.发明授权Method and device for quantifying the uptake of at least one radiotracer in a body region of a patient of interest to a positron emission tomography measurement 有权用于量化目标患者身体区域中至少一个放射性示踪剂对正电子发射断层摄影测量的摄取的方法和装置公开(公告)号：US08208987B2
公开(公告)日：2012-06-26
申请号：US12222923
申请日：2008-08-20
申请人： Arne Hengerer , Ralph Strecker
发明人： Arne Hengerer , Ralph Strecker
IPC分类号： A61B5/00
CPC分类号： G01R33/56366 , A61B6/037 , A61B6/507 , G01R33/481 , G01R33/5601
摘要： A method for quantifying the uptake of at least one radiotracer in a body region of a patient of interest to a positron emission tomography measurement is disclosed. In at least one embodiment of the method, the uptake of the radiotracer in the body region of the patient of interest to the positron emission tomography measurement is quantified taking into account at least one permeability information item relating to the permeability of at least one blood vessel of the patient, in particular in the body region of interest.
摘要翻译： 公开了一种用于定量正电子发射断层摄影测量的感兴趣的患者的身体区域中的至少一个放射性示踪剂的摄取的方法。 在该方法的至少一个实施方案中，考虑到与至少一个血管的渗透性有关的至少一个渗透性信息项，对正电子发射断层摄影测量的感兴趣的患者的身体区域中的放射性示踪剂的摄取量化 的患者，特别是在感兴趣的身体区域。
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5.发明申请Method for quantifying the uptake of at least one radiotracer in a body region of a patient of interest to a positron emission tomography measurement 有权用于量化目标患者的身体区域中的至少一个放射性示踪剂对正电子发射断层摄影测量的摄取的方法公开(公告)号：US20090117044A1
公开(公告)日：2009-05-07
申请号：US12222923
申请日：2008-08-20
申请人： Arne Hengerer , Ralph Strecker
发明人： Arne Hengerer , Ralph Strecker
CPC分类号： G01R33/56366 , A61B6/037 , A61B6/507 , G01R33/481 , G01R33/5601
摘要： A method for quantifying the uptake of at least one radiotracer in a body region of a patient of interest to a positron emission tomography measurement is disclosed. In at least one embodiment of the method, the uptake of the radiotracer in the body region of the patient of interest to the positron emission tomography measurement is quantified taking into account at least one permeability information item relating to the permeability of at least one blood vessel of the patient, in particular in the body region of interest.
摘要翻译： 公开了一种用于定量正电子发射断层摄影测量的感兴趣的患者的身体区域中的至少一个放射性示踪剂的摄取的方法。 在该方法的至少一个实施方案中，考虑到与至少一个血管的渗透性有关的至少一个渗透性信息项，对正电子发射断层摄影测量的感兴趣的患者的身体区域中的放射性示踪剂的摄取量化 的患者，特别是在感兴趣的身体区域。
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6.发明申请AUTOMATED METHOD FOR ASSESSMENT OF TUMOR RESPONSE TO THERAPY WITH MULTI-PARAMETRIC MRI 审中-公开用于多参数MRI治疗肿瘤反应的自动化方法公开(公告)号：US20100254584A1
公开(公告)日：2010-10-07
申请号：US12751086
申请日：2010-03-31
IPC分类号： G06K9/00
CPC分类号： A61B5/055 , G01R33/5601 , G01R33/5608 , G01R33/56341 , G01R33/56366 , G06T7/0014 , G06T7/162 , G06T2207/10076 , G06T2207/20104 , G06T2207/30096
摘要： A method for assessing a tumor's response to therapy, includes providing images of a first study of a patient and images of a second study of the patient, the second study occurring after the first study and after the patient undergoes therapy to treat a tumor, each study comprising first and second types of functional magnetic resonance (fMR) images, performing a first registration in which the images within each study are registered, performing a second registration in which reference images from both studies are co-registered, segmenting the tumor in an image of each of the second registered studies; and determining that first and second fMR measure differences exist between the segmented tumor's of the first and second studies, the first fMR measure difference being obtained from the first type of fMR images, the second fMR measure difference being obtained from the second type of fMR images.
摘要翻译： 用于评估肿瘤对治疗的反应的方法包括提供患者的第一次研究的图像和患者的第二次研究的图像，第二次研究发生在第一次研究之后，以及在患者进行治疗以治疗肿瘤之后 研究包括第一和第二类型的功能磁共振（fMR）图像，执行其中登记每个研究中的图像的第一登记，执行第二登记，其中来自两个研究的参考图像共同登记，将肿瘤分成 每个第二次注册研究的形象; 并且确定在第一和第二研究的分段肿瘤之间存在第一和第二fMR测量差异，从第一类型的fMR图像获得的第一fMR测量差异，从第二类型fMR图像获得的第二fMR测量差异 。
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