公开(公告)号：US08208987B2

公开(公告)日：2012-06-26

申请号：US12222923

申请日：2008-08-20

申请人： Arne Hengerer ,  Ralph Strecker

发明人： Arne Hengerer ,  Ralph Strecker

IPC分类号： A61B5/00

CPC分类号： G01R33/56366 ,  A61B6/037 ,  A61B6/507 ,  G01R33/481 ,  G01R33/5601

摘要： A method for quantifying the uptake of at least one radiotracer in a body region of a patient of interest to a positron emission tomography measurement is disclosed. In at least one embodiment of the method, the uptake of the radiotracer in the body region of the patient of interest to the positron emission tomography measurement is quantified taking into account at least one permeability information item relating to the permeability of at least one blood vessel of the patient, in particular in the body region of interest.

摘要翻译： 公开了一种用于定量正电子发射断层摄影测量的感兴趣的患者的身体区域中的至少一个放射性示踪剂的摄取的方法。 在该方法的至少一个实施方案中，考虑到与至少一个血管的渗透性有关的至少一个渗透性信息项，对正电子发射断层摄影测量的感兴趣的患者的身体区域中的放射性示踪剂的摄取量化 的患者，特别是在感兴趣的身体区域。

公开(公告)号：US20090117044A1

公开(公告)日：2009-05-07

申请号：US12222923

申请日：2008-08-20

申请人： Arne Hengerer ,  Ralph Strecker

发明人： Arne Hengerer ,  Ralph Strecker

IPC分类号： A61K49/00 ,  A61P43/00 ,  G01T1/166

CPC分类号： G01R33/56366 ,  A61B6/037 ,  A61B6/507 ,  G01R33/481 ,  G01R33/5601

摘要： A method for quantifying the uptake of at least one radiotracer in a body region of a patient of interest to a positron emission tomography measurement is disclosed. In at least one embodiment of the method, the uptake of the radiotracer in the body region of the patient of interest to the positron emission tomography measurement is quantified taking into account at least one permeability information item relating to the permeability of at least one blood vessel of the patient, in particular in the body region of interest.

摘要翻译： 公开了一种用于定量正电子发射断层摄影测量的感兴趣的患者的身体区域中的至少一个放射性示踪剂的摄取的方法。 在该方法的至少一个实施方案中，考虑到与至少一个血管的渗透性有关的至少一个渗透性信息项，对正电子发射断层摄影测量的感兴趣的患者的身体区域中的放射性示踪剂的摄取量化 的患者，特别是在感兴趣的身体区域。

公开(公告)号：US20090062630A1

公开(公告)日：2009-03-05

申请号：US12222776

申请日：2008-08-15

申请人： Arne Hengerer ,  Robert Krieg ,  Sebastian Schmidt ,  Ralph Strecker

发明人： Arne Hengerer ,  Robert Krieg ,  Sebastian Schmidt ,  Ralph Strecker

IPC分类号： A61B5/145 ,  C12Q1/00 ,  A61B5/05 ,  A61F2/06

CPC分类号： A61B5/415 ,  A61B5/05 ,  A61B5/06 ,  A61B5/418 ,  A61K49/16 ,  A61K49/18 ,  A61K49/1875 ,  B82Y5/00 ,  G01R33/50 ,  G01R33/5601

摘要： A sensor is disclosed for permitting detection of a substance in the body of a living being. In at least one embodiment, the sensor includes probe molecules, for binding the substance that is to be detected, and marking elements designed in such a way that the binding of the probe molecules to the substance to be detected is detectable by way of an imaging modality. For example, antigens or pathogens that are present only in a low concentration can be detected.

摘要翻译： 公开了用于允许检测生物体内物质的传感器。 在至少一个实施例中，传感器包括用于结合要检测的物质的探针分子和以使得探针分子与待检测物质的结合可通过成像检测的方式设计的标记元件 模态 例如，可以检测出仅存在低浓度的抗原或病原体。

公开(公告)号：US20080294035A1

公开(公告)日：2008-11-27

申请号：US12124681

申请日：2008-05-21

申请人： Stefan Zwick ,  Ralph Strecker ,  Fabian Kiessling ,  Arne Hengerer ,  Sebastian Schmidt

发明人： Stefan Zwick ,  Ralph Strecker ,  Fabian Kiessling ,  Arne Hengerer ,  Sebastian Schmidt

IPC分类号： A61B5/055 ,  A61K49/00

CPC分类号： A61B5/055 ,  A61B5/0515 ,  G06T7/60

摘要： A system and method of evaluating the effectiveness of antiangionetic therapy is described. A patient or test animal is treated with an antiangionetic substance. Magnetic resonance imaging data is obtained prior to and subsequent to the treatment. The parameters of the imaging process are configured so that, by administering a intravascular contrast agent, the relative size of the microvascular and the total vascular volumes in a region of interest may be obtained, so as to form a vascular size index. The value of the vascular size index and other pharmacokinetic data obtained by the administration of a diffusible contrast agent are used to assess the efficacy of the treatment or the antiangionetic substance being studied.

摘要翻译： 描述了评估抗血管治疗疗效的系统和方法。 患者或测试动物用抗血友病药物治疗。 在治疗之前和之后获得磁共振成像数据。 成像过程的参数被配置为使得通过施用血管内造影剂可以获得感兴趣区域中的微血管的相对大小和总血管体积，从而形成血管尺寸指数。 使用通过施用可扩散造影剂获得的血管尺寸指数和其他药代动力学数据的值来评估所研究的治疗或抗血小球药物的功效。

公开(公告)号：US08195275B2

公开(公告)日：2012-06-05

申请号：US12124681

申请日：2008-05-21

申请人： Stefan Zwick ,  Ralph Strecker ,  Fabian Kiessling ,  Arne Hengerer ,  Sebastian Schmidt

发明人： Stefan Zwick ,  Ralph Strecker ,  Fabian Kiessling ,  Arne Hengerer ,  Sebastian Schmidt

IPC分类号： A61B5/055 ,  G06K9/00

CPC分类号： A61B5/055 ,  A61B5/0515 ,  G06T7/60

摘要： A system and method of evaluating the effectiveness of antiangionetic therapy is described. A patient or test animal is treated with an antiangionetic substance. Magnetic resonance imaging data is obtained prior to and subsequent to the treatment. The parameters of the imaging process are configured so that, by administering a intravascular contrast agent, the relative size of the microvascular and the total vascular volumes in a region of interest may be obtained, so as to form a vascular size index. The value of the vascular size index and other pharmacokinetic data obtained by the administration of a diffusible contrast agent are used to assess the efficacy of the treatment or the antiangionetic substance being studied.

摘要翻译： 描述了评估抗血管治疗疗效的系统和方法。 患者或测试动物用抗血友病药物治疗。 在治疗之前和之后获得磁共振成像数据。 成像过程的参数被配置为使得通过施用血管内造影剂可以获得感兴趣区域中的微血管的相对大小和总血管体积，从而形成血管尺寸指数。 使用通过施用可扩散造影剂获得的血管尺寸指数和其他药代动力学数据的值来评估所研究的治疗或抗血小球药物的功效。

公开(公告)号：US09651639B2

公开(公告)日：2017-05-16

申请号：US13894623

申请日：2013-05-15

申请人： Björn Heismann ,  Arne Hengerer ,  Sebastian Schmidt

发明人： Björn Heismann ,  Arne Hengerer ,  Sebastian Schmidt

IPC分类号： G01R33/48 ,  G01R33/483 ,  A61B5/055 ,  G01R33/485 ,  G01R33/563

CPC分类号： G01R33/485 ,  A61B5/055 ,  G01R33/48 ,  G01R33/4806 ,  G01R33/483 ,  G01R33/5616 ,  G01R33/56366

摘要： A method for determining a change over time in a biomarker in a region to be examined of a patient is provided. The change is determined from magnetic resonance data using a magnetic resonance measuring system with sequences and protocols for measuring the biomarkers by functional resting state connectivity by rsfMRI, perfusion values, magnetic resonance spectra of voxels, or morphometry of organs. A control unit has programs which evaluates the biomarker and a data memory which stores the results of the evaluation and additional data. During a first examination, a quantity result of the biomarkers is determined and stored in the data memory. During a follow-up examination, at least one previous item of the result and additional data from the first examination stored in the data memory are used for determining a quantitative change in the biomarker.

公开(公告)号：US20160363641A1

公开(公告)日：2016-12-15

申请号：US15183201

申请日：2016-06-15

申请人： Matthew Finnerty ,  Arne Hengerer ,  Volker Matschl ,  Gregory Weisberg ,  Tsinghua Zheng

发明人： Matthew Finnerty ,  Arne Hengerer ,  Volker Matschl ,  Gregory Weisberg ,  Tsinghua Zheng

IPC分类号： G01R33/3415 ,  G01R33/34

CPC分类号： G01R33/3415 ,  G01R33/34007 ,  G01R33/3678

摘要： In order to provide interventional access during an image-guided interventional procedure, while increasing the signal-to-noise ratio for generated images compared to a single loop coil, a local coil includes a single coil element disposed around an opening through the local coil and two coil elements positioned on opposite sides of the single coil element. The opening provides access for an interventional tool used during the image-guided interventional procedure.

摘要翻译： 为了在图像引导的介入过程期间提供介入通路，与单个环形线圈相比，在增加所产生的图像的信噪比的同时，局部线圈包括设置在通过局部线圈的开口周围的单个线圈元件， 两个线圈元件位于单个线圈元件的相对侧上。 该开放提供了在图像引导介入程序期间使用的介入工具的访问。

公开(公告)号：US20160073925A1

公开(公告)日：2016-03-17

申请号：US14837060

申请日：2015-08-27

申请人： David Grodzki ,  Annemarie Hausotte ,  Björn Heismann ,  Arne Hengerer ,  Mark-Aleksi Keller-Reichenbecher ,  Sebastian Schmidt

发明人： David Grodzki ,  Annemarie Hausotte ,  Björn Heismann ,  Arne Hengerer ,  Mark-Aleksi Keller-Reichenbecher ,  Sebastian Schmidt

IPC分类号： A61B5/06 ,  A61B5/055 ,  G06T11/60 ,  G06T11/00 ,  G06T7/00 ,  A61N5/10 ,  A61B5/00

CPC分类号： G06T11/60 ,  A61B5/055 ,  A61B5/064 ,  A61B34/20 ,  A61B90/39 ,  A61N5/1001 ,  A61N5/1049 ,  A61N2005/1055 ,  G01R33/286

摘要： An apparatus is provided for obtaining a spatial instrument image of a medical instrument with a magnetic resonance tomography device, wherein the apparatus includes a medical instrument, a magnetic resonance tomography device, and a computing and control device. The medical instrument includes at least one marker material in at least one region, the marker material having a nuclear spin resonance outside of the proton resonance and wherein the computing and control device is configured to control the magnetic resonance tomography device such that a nuclear spin tomography imaging may be implemented by the magnetic resonance tomography device with the nuclear spin resonance of the at least one marker material in order to obtain a spatial instrument image, and wherein the computing and control device is configured to accept the instrument image. A corresponding medical instrument and a corresponding method are also provided.

摘要翻译： 提供一种用于获得具有磁共振断层摄影装置的医疗器械的空间仪器图像的装置，其中所述装置包括医疗器械，磁共振断层摄影装置和计算和控制装置。 所述医疗器械在至少一个区域中包括至少一种标记材料，所述标记材料在所述质子共振之外具有核自旋共振，并且其中所述计算和控制装置被配置为控制所述磁共振断层摄影装置，使得核自旋断层扫描 成像可以通过具有至少一种标记材料的核自旋共振的磁共振断层摄影装置来实现，以获得空间仪器图像，并且其中计算和控制装置被配置为接受仪器图像。 还提供了相应的医疗仪器和相应的方法。

公开(公告)号：US08529615B2

公开(公告)日：2013-09-10

申请号：US13042532

申请日：2011-03-08

申请人： Arne Hengerer

发明人： Arne Hengerer

IPC分类号： A61F2/06

CPC分类号： A61B5/055 ,  A61B5/0515 ,  A61B5/6846 ,  A61B90/39 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/602 ,  A61L2300/80 ,  A61L2400/12

摘要： An element is disclosed that can be fixed in a blood vessel of a living being has a base body to which a first substance and/or a second substance is/are applied at least in parts. In at least one embodiment, the first substance is determined in such a way that it can be detected from outside of the body of the living being by way of a first non-invasive detection method and reacts with at least one first biochemical substance that is released by the living being into the blood vessel during a first pathological condition of the living being, with the result that the quantity of first substance applied to the base body is reduced. The second substance is determined in such a way that it binds at least one second biochemical substance that is released by the living being into the blood vessel during a second pathological condition of the living being and the presence of the bound substance can be detected from outside of the body of the living being by way of a second non-invasive detection method.

摘要翻译： 公开了一种能够固定在生物体的血管中的元件，其具有至少部分地施加有第一物质和/或第二物质的基体。 在至少一个实施方案中，第一物质以这样的方式确定：其可以通过第一非侵入性检测方法从生物体内从外部检测，并与至少一种第一生化物质反应 在生命的第一病态下，由生物释放到血管中，结果是施加到基体的第一物质的量减少。 第二物质以这样的方式确定，即在活体的第二病理状态期间，将生物释放的至少一种第二生化物质结合到血管中，并且可以从外部检测结合物质的存在 通过第二种非侵入性检测方法来检测生命体。

公开(公告)号：US20110224533A1

公开(公告)日：2011-09-15

申请号：US13042532

申请日：2011-03-08

申请人： Arne Hengerer

发明人： Arne Hengerer

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/0515 ,  A61B5/6846 ,  A61B90/39 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/602 ,  A61L2300/80 ,  A61L2400/12

摘要： An element is disclosed that can be fixed in a blood vessel of a living being has a base body to which a first substance and/or a second substance is/are applied at least in parts. In at least one embodiment, the first substance is determined in such a way that it can be detected from outside of the body of the living being by way of a first non-invasive detection method and reacts with at least one first biochemical substance that is released by the living being into the blood vessel during a first pathological condition of the living being, with the result that the quantity of first substance applied to the base body is reduced. The second substance is determined in such a way that it binds at least one second biochemical substance that is released by the living being into the blood vessel during a second pathological condition of the living being and the presence of the bound substance can be detected from outside of the body of the living being by way of a second non-invasive detection method.

摘要翻译： 公开了一种能够固定在生物体的血管中的元件，其具有至少部分地施加有第一物质和/或第二物质的基体。 在至少一个实施方案中，第一物质以这样的方式确定：其可以通过第一非侵入性检测方法从生物体内从外部检测，并与至少一种第一生化物质反应 在生命的第一病态下，由生物释放到血管中，结果是施加到基体的第一物质的量减少。 第二物质以这样的方式确定，即在活体的第二病理状态期间，将生物释放的至少一种第二生化物质结合到血管中，并且可以从外部检测结合物质的存在 通过第二种非侵入性检测方法来检测生命体。