公开(公告)号：US07439737B2

公开(公告)日：2008-10-21

申请号：US11569071

申请日：2005-05-03

申请人： Steffen Weiss ,  Tobias Schaeffter

发明人： Steffen Weiss ,  Tobias Schaeffter

IPC分类号： G01V3/00

CPC分类号： G01R33/56 ,  G01R33/4824 ,  G01R33/561 ,  G01R33/5619

摘要： A method of magnetic resonance imaging is provided. The method includes the steps of applying a preparation pulse sequence to a subject (16) disposed in an examination region (14), acquiring k-space data related to a plurality of k-space trajectories through the center of k-space such as radial trajectories and reconstructing a first image form the k-space data wherein data within a region (210) around the center of k-space (205) of at least a first of the k-space trajectories is not used. Rather, data of only a limited number of views within said region is used for image reconstruction. Hence, image contrast is essentially determined by said limited number of views.

摘要翻译： 提供了一种磁共振成像方法。 该方法包括以下步骤：将准备脉冲序列应用于设置在检查区域（14）中的对象（16），通过k空间的中心获取与多个k空间轨迹相关的k空间数据，例如径向 轨迹，并且重建第一图像，形成k空间数据，其中不使用至少k个空间轨迹中的至少第一个的k空间（205）的中心周围的区域（210）内的数据。 相反，在所述区域内只有有限数量的视图的数据被用于图像重构。 因此，图像对比度基本上由所述有限数量的视图来确定。

公开(公告)号：US20080077002A1

公开(公告)日：2008-03-27

申请号：US11574747

申请日：2005-09-06

申请人： Tim Nielsen ,  Steffen Weiss ,  Tobias Schaeffter ,  Bernhard Gleich ,  Paul Haaker ,  Udo Van Stevendaal ,  Peter Mazurkewitz

发明人： Tim Nielsen ,  Steffen Weiss ,  Tobias Schaeffter ,  Bernhard Gleich ,  Paul Haaker ,  Udo Van Stevendaal ,  Peter Mazurkewitz

IPC分类号： A61B5/05

CPC分类号： A61K49/225 ,  A61B5/0059 ,  A61K49/0091 ,  G01N21/1717 ,  G01N2021/6441

摘要： The present invention relates to novel methods and compounds for combined opticalultrasound imaging. The compounds of the present invention relate to particles comprising fluorescence donor and acceptor molecules for energy exchange via FRET. The methods of the present invention use ultrasound to modify the distance between donor and acceptor molecules present on the particles, and to consequently modify the fluorescence emitted by the donor and acceptor. The compounds and methods of the present invention are useful in medical or diagnostic imaging.

摘要翻译： 本发明涉及组合光超声成像的新方法和化合物。 本发明的化合物涉及通过FRET进行能量交换的包含荧光供体和受体分子的颗粒。 本发明的方法使用超声波改变存在于颗粒上的供体和受体分子之间的距离，并因此改变由供体和受体发出的荧光。 本发明的化合物和方法可用于医学或诊断成像。

公开(公告)号：US20080012563A1

公开(公告)日：2008-01-17

申请号：US11569071

申请日：2005-05-03

申请人： Steffen Weiss ,  Tobias Schaeffter

发明人： Steffen Weiss ,  Tobias Schaeffter

IPC分类号： G01R33/56

CPC分类号： G01R33/56 ,  G01R33/4824 ,  G01R33/561 ,  G01R33/5619

摘要： A method of magnetic resonance imaging is provided. The method includes the steps of applying a preparation pulse sequence to a subject (16) disposed in an examination region (14), acquiring k-space data related to a plurality of k-space trajectories through the center of k-space such as radial trajectories and reconstructing a first image form the k-space data wherein data within a region (210) around the center of k-space (205) of at least a first of the k-space trajectories is not used. Rather, data of only a limited number of views within said region is used for image reconstruction. Hence, image contrast is essentially determined by said limited number of views.

摘要翻译： 提供了一种磁共振成像方法。 该方法包括以下步骤：将准备脉冲序列应用于设置在检查区域（14）中的对象（16），通过k空间的中心获取与多个k空间轨迹相关的k空间数据，例如径向 轨迹，并且重建第一图像，形成k空间数据，其中不使用至少k个空间轨迹中的至少第一个的k空间（205）的中心周围的区域（210）内的数据。 相反，在所述区域内只有有限数量的视图的数据被用于图像重构。 因此，图像对比度基本上由所述有限数量的视图来确定。

公开(公告)号：US20080230715A1

公开(公告)日：2008-09-25

申请号：US11997417

申请日：2006-07-25

申请人： Tim Nielsen ,  Udo Van Stevendaal ,  Bernhard Gleich ,  Tobias Schaeffter ,  Paul Haaker ,  Peter Mazurkewitz ,  Steffen Weiss

发明人： Tim Nielsen ,  Udo Van Stevendaal ,  Bernhard Gleich ,  Tobias Schaeffter ,  Paul Haaker ,  Peter Mazurkewitz ,  Steffen Weiss

IPC分类号： G01J1/58

CPC分类号： A61B5/0059 ,  A61B5/05

摘要： An optical imaging apparatus (100) for examination of an object of interest (101), the optical imaging apparatus (100) comprising an optical radiation source (102) adapted to emit a primary optical radiation beam onto the object of interest (101), an optical radiation detector (106) adapted to detect a secondary optical radiation beam emitted by the object of interest (101) upon absorbing the primary optical radiation beam, a magnetic field generating element (107) adapted to generate an inhomogeneous magnetic field varying along an extension of the object of interest (101), and a determination unit (108) adapted to determine information concerning the object of interest (101) based on an analysis of the detected secondary optical radiation beam in combination with an analysis of the inhomogeneous magnetic field.

摘要翻译： 一种用于检查感兴趣物体（101）的光学成像设备（100），所述光学成像设备（100）包括适于将主要光辐射束发射到感兴趣对象（101）上的光辐射源（102） 适于在吸收主光辐射束时检测由感兴趣物体（101）发射的次级光辐射束的光学辐射检测器（106），适于产生沿着所述第一光辐射束变化的非均匀磁场的磁场产生元件（107） 感兴趣对象的扩展（101），以及确定单元（108），其适于基于对所检测到的次级光辐射束的分析来确定与感兴趣对象（101）有关的信息，以及非均匀磁场的分析 。

公开(公告)号：US20060258934A1

公开(公告)日：2006-11-16

申请号：US10554307

申请日：2004-04-13

申请人： Michael Zenge ,  Steffen Weiss ,  Tobias Schaeffter ,  Ralph Sinkus

发明人： Michael Zenge ,  Steffen Weiss ,  Tobias Schaeffter ,  Ralph Sinkus

IPC分类号： A61B5/05

CPC分类号： G01R33/286

摘要： The invention relates to a magnetic resonance method for locating interventional devices, in particular in vivo, in which the interventional device bears a marking which in magnetic resonance images influences the measured signals or generates its own measured signals, where the measured signals are processed by means of a one-dimensional signal processing method in order to suppress noise and artefacts. This may in particular be the maximum entropy method, which can be further expanded by the use of model functions. These model functions are subtracted from the measured signals during the iterative method in order in this way to additionally improve the elimination of artefacts. As an alternative to the use of the maximum entropy method, the use of filters, in particular Wiener filters or bandpass filters, is also possible.

摘要翻译： 本发明涉及用于定位介入装置，特别是体内的磁共振方法，其中介入装置具有在磁共振图像中影响测量信号或产生其自身测量信号的标记，其中测量信号通过装置 的一维信号处理方法，以便抑制噪声和伪影。 这可能特别是最大熵方法，可以通过使用模型函数进一步扩展。 在迭代方法中，从测量信号中减去这些模型函数，以此方式另外提高了人为因素的消除。 作为使用最大熵方法的替代方案，也可以使用滤波器，特别是维纳滤波器或带通滤波器。

公开(公告)号：US20080265890A1

公开(公告)日：2008-10-30

申请号：US12091303

申请日：2006-10-03

申请人： Ingmar Graesslin ,  Tobias Schaeffter ,  Paul R. Harvey

发明人： Ingmar Graesslin ,  Tobias Schaeffter ,  Paul R. Harvey

IPC分类号： G01R33/36

CPC分类号： G01R33/3635

摘要： A medical imaging system (2) excites multiple nuclei through a single RF amplifier (24). The medical imaging system (2) includes a magnet (10) that generates a main magnetic field (Bo) in an examination region. A gradient coil (14) superimposes magnetic field gradients (G) on the main magnetic field Bo. At least one transmitter (28) generates multi-nuclei excitation pulses associated with at least two different isotopes and two different frequency spectra. The single amplifier (24) sends the multi-nuclei excitation pulses to a RF coil (18, 20) for application to the examination region.

摘要翻译： 医学成像系统（2）通过单个RF放大器（24）激发多个核。 医疗成像系统（2）包括在检查区域中产生主磁场（Bo）的磁体（10）。 梯度线圈（14）将磁场梯度（G）叠加在主磁场Bo上。 至少一个发射器（28）产生与至少两个不同同位素和两个不同频谱相关联的多核激励脉冲。 单个放大器（24）将多核激励脉冲发送到RF线圈（18,20）以供应用于检查区域。

公开(公告)号：US06466015B2

公开(公告)日：2002-10-15

申请号：US09982263

申请日：2001-10-17

申请人： Tobias Schaeffter ,  Peter Koken

发明人： Tobias Schaeffter ,  Peter Koken

IPC分类号： G01V300

CPC分类号： G01R33/56554 ,  G01R33/56518

摘要： The invention relates to an MR imaging method, notably for real-time imaging, in which the phase errors that occur in the MR signals because of inter alia eddy currents, are continuously monitored on the basis of the MR data sets acquired for imaging. To this end, MR signals that are successively acquired with different read-out gradients are related to one another in order to detect changes in the eddy current behavior on the basis of the phase differences. If necessary, calibration measurements are initiated so as to determine phase correction profiles whereby the phase errors of the MR data sets are compensated. For the imaging in accordance with the invention use can be made of Echo Planar Imaging (EPI) sequences for which individual, successively acquired echo signals are related to one another in order to monitor the phase errors. These echo signals are measured with the same phase encoding and with each time opposed read-out gradients for this purpose.

公开(公告)号：US08175678B2

公开(公告)日：2012-05-08

申请号：US12066510

申请日：2006-09-07

申请人： Hannes Dahnke ,  Tobias Schaeffter

发明人： Hannes Dahnke ,  Tobias Schaeffter

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B6/481 ,  A61K49/1818 ,  B82Y5/00 ,  G01R33/50 ,  G01R33/5601 ,  G01R33/56366

摘要： MRI based molecular imaging is strongly supported by the accurate quantification of contrast agents. According to an exemplary embodiment of the present invention, contrast agent is applied on the basis of a multiple injection application scheme, during which changes in relaxation rate are determined. This may provide for an accurate determination of tumor vascularity via MRI relaxometry.

摘要翻译： 通过造影剂的准确定量强烈支持基于MRI的分子成像。 根据本发明的示例性实施方案，在多次注射施用方案的基础上应用造影剂，在此期间确定松弛率的变化。 这可以通过MRI弛豫测定来准确地确定肿瘤血管。

公开(公告)号：US07615997B2

公开(公告)日：2009-11-10

申请号：US12091303

申请日：2006-10-03

申请人： Ingmar Graesslin ,  Tobias Schaeffter ,  Paul R. Harvey

发明人： Ingmar Graesslin ,  Tobias Schaeffter ,  Paul R. Harvey

IPC分类号： G01V3/00

CPC分类号： G01R33/3635

摘要： A medical imaging system (2) excites multiple nuclei through a single RF amplifier (24). The medical imaging system (2) includes a magnet (10) that generates a main magnetic field (Bo) in an examination region. A gradient coil (14) superimposes magnetic field gradients (G) on the main magnetic field Bo. At least one transmitter (28) generates multi-nuclei excitation pulses associated with at least two different isotopes and two different frequency spectra. The single amplifier (24) sends the multi-nuclei excitation pulses to a RF coil (18, 20) for application to the examination region.

摘要翻译： 医学成像系统（2）通过单个RF放大器（24）激发多个核。 医疗成像系统（2）包括在检查区域中产生主磁场（Bo）的磁体（10）。 梯度线圈（14）将磁场梯度（G）叠加在主磁场Bo上。 至少一个发射器（28）产生与至少两个不同同位素和两个不同频谱相关联的多核激励脉冲。 单个放大器（24）将多核激励脉冲发送到RF线圈（18,20）以供应用于检查区域。

公开(公告)号：US20090227860A1

公开(公告)日：2009-09-10

申请号：US11573408

申请日：2005-08-08

申请人： Hannes Dahnke ,  Tobias Schaeffter

发明人： Hannes Dahnke ,  Tobias Schaeffter

IPC分类号： A61B5/055

CPC分类号： G01R33/50 ,  G01R33/281 ,  G01R33/56536 ,  G01R33/56563

摘要： The invention relates to an MR method for the quantitative determination of local relaxation time values in an examination volume. Firstly, a plurality of echo signals (1, 2, 3) with different echo time values (t1, t2, t3) are recorded in a phase-sensitive manner. From these echo signals (1, 2, 3), complex MR images (4, 5, 6) are then reconstructed for the different echo time values (t1, t2, t3). Next, local resonant frequency values (7) are calculated for each image point from the echo-time-dependent change in the phases of the complex image values, and then preliminary local magnetic field inhomogeneity values (8) are calculated from the local resonant frequency values (7). The invention proposes that the local relaxation time values (10) be determined from the echo-time-dependent change in the amplitudes of the image values and correction of the local relaxation time values (10) be carried out taking account of final local magnetic field inhomogeneity values. The preliminary magnetic field inhomogeneity values (8) are used as start values for an iterative optimization procedure (19) for determining the final local magnetic field inhomogeneity values.

摘要翻译： 本发明涉及用于定量测定检查体积中局部弛豫时间值的MR方法。 首先，以相敏的方式记录具有不同回波时间值（t1，t2，t3）的多个回波信号（1,2,3）。 然后，根据这些回波信号（1,2,3），对于不同的回波时间值（t1，t2，t3）重构复数MR图像（4,5,6）。 接下来，从复图像值的相位的回波 - 时间相关的变化中，针对每个图像点计算局部谐振频率值（7），然后从局部谐振频率计算初步局部磁场不均匀性值（8） 值（7）。 本发明提出，根据图像值幅度的回波 - 时间相关的变化确定局部弛豫时间值（10），并且考虑到最终局部磁场来执行局部弛豫时间值（10）的校正 不均匀性值。 将初步磁场不均匀性值（8）用作用于确定最终局部磁场不均匀性值的迭代优化程序（19）的起始值。