公开(公告)号：US20080230715A1

公开(公告)日：2008-09-25

申请号：US11997417

申请日：2006-07-25

申请人： Tim Nielsen ,  Udo Van Stevendaal ,  Bernhard Gleich ,  Tobias Schaeffter ,  Paul Haaker ,  Peter Mazurkewitz ,  Steffen Weiss

发明人： Tim Nielsen ,  Udo Van Stevendaal ,  Bernhard Gleich ,  Tobias Schaeffter ,  Paul Haaker ,  Peter Mazurkewitz ,  Steffen Weiss

IPC分类号： G01J1/58

CPC分类号： A61B5/0059 ,  A61B5/05

摘要： An optical imaging apparatus (100) for examination of an object of interest (101), the optical imaging apparatus (100) comprising an optical radiation source (102) adapted to emit a primary optical radiation beam onto the object of interest (101), an optical radiation detector (106) adapted to detect a secondary optical radiation beam emitted by the object of interest (101) upon absorbing the primary optical radiation beam, a magnetic field generating element (107) adapted to generate an inhomogeneous magnetic field varying along an extension of the object of interest (101), and a determination unit (108) adapted to determine information concerning the object of interest (101) based on an analysis of the detected secondary optical radiation beam in combination with an analysis of the inhomogeneous magnetic field.

摘要翻译： 一种用于检查感兴趣物体（101）的光学成像设备（100），所述光学成像设备（100）包括适于将主要光辐射束发射到感兴趣对象（101）上的光辐射源（102） 适于在吸收主光辐射束时检测由感兴趣物体（101）发射的次级光辐射束的光学辐射检测器（106），适于产生沿着所述第一光辐射束变化的非均匀磁场的磁场产生元件（107） 感兴趣对象的扩展（101），以及确定单元（108），其适于基于对所检测到的次级光辐射束的分析来确定与感兴趣对象（101）有关的信息，以及非均匀磁场的分析 。

公开(公告)号：US20080077002A1

公开(公告)日：2008-03-27

申请号：US11574747

申请日：2005-09-06

申请人： Tim Nielsen ,  Steffen Weiss ,  Tobias Schaeffter ,  Bernhard Gleich ,  Paul Haaker ,  Udo Van Stevendaal ,  Peter Mazurkewitz

发明人： Tim Nielsen ,  Steffen Weiss ,  Tobias Schaeffter ,  Bernhard Gleich ,  Paul Haaker ,  Udo Van Stevendaal ,  Peter Mazurkewitz

IPC分类号： A61B5/05

CPC分类号： A61K49/225 ,  A61B5/0059 ,  A61K49/0091 ,  G01N21/1717 ,  G01N2021/6441

摘要： The present invention relates to novel methods and compounds for combined opticalultrasound imaging. The compounds of the present invention relate to particles comprising fluorescence donor and acceptor molecules for energy exchange via FRET. The methods of the present invention use ultrasound to modify the distance between donor and acceptor molecules present on the particles, and to consequently modify the fluorescence emitted by the donor and acceptor. The compounds and methods of the present invention are useful in medical or diagnostic imaging.

摘要翻译： 本发明涉及组合光超声成像的新方法和化合物。 本发明的化合物涉及通过FRET进行能量交换的包含荧光供体和受体分子的颗粒。 本发明的方法使用超声波改变存在于颗粒上的供体和受体分子之间的距离，并因此改变由供体和受体发出的荧光。 本发明的化合物和方法可用于医学或诊断成像。

公开(公告)号：US20090281416A1

公开(公告)日：2009-11-12

申请号：US11721565

申请日：2005-12-14

申请人： Bernhard Gleich ,  Juergen Weizenecker ,  Tim Nielsen

发明人： Bernhard Gleich ,  Juergen Weizenecker ,  Tim Nielsen

IPC分类号： A61B5/05

CPC分类号： A61B5/05 ,  A61B5/0515

摘要： The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non- saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area. The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument.

摘要翻译： 本发明涉及一种用于确定检查区域中磁性颗粒的空间分布的装置和方法。 磁场装置用于产生具有低场强的至少一个区域的空间不均匀梯度磁场，其中颗粒的磁化处于非饱和状态，而它们处于饱和状态 剩余地区。 通过使用改变方法在检查区域内移动具有低场强的区域，可以通过检测装置从外部检测磁性颗粒的磁化强度的变化，并且包含关于磁性颗粒的空间分布的信息 在考场。 磁场装置或改变装置或检测装置或这些装置的组合至少部分地布置在医疗器械上。

公开(公告)号：US08355771B2

公开(公告)日：2013-01-15

申请号：US11721371

申请日：2005-12-06

申请人： Bernhard Gleich ,  Jurgen Weizenecker ,  Tim Nielsen

发明人： Bernhard Gleich ,  Jurgen Weizenecker ,  Tim Nielsen

IPC分类号： A61B5/05

CPC分类号： A61B5/0515 ,  A61B5/05 ,  A61B5/7257

摘要： The invention relates to a method of determining a spatial distribution of magnetic particles in an examination zone, in which a magnetic field is generated that has a first sub-zone of lower magnetic field strength and a second sub-zone of higher magnetic field strength. The positions of the two sub-zones are changed, as a result of which the magnetization in the examination zone changes. Measured values that depend on the change in magnetization are acquired. A reference response function by means of which measured values can be determined mathematically from a spatial distribution of magnetic particles is then determined by means of at least extensive magnetic specimen distribution. Finally, the spatial distribution of magnetic particles is reconstructed from the measured values by means of the reference response function.

摘要翻译： 本发明涉及一种确定检测区中的磁性颗粒的空间分布的方法，其中产生具有较低磁场强度的第一子区和较高磁场强度的第二子区的磁场。 两个子区域的位置改变，结果是检查区域的磁化改变。 取决于磁化变化的测量值。 然后可以借助于至少广泛的磁性样本分布来确定参考响应函数，通过该参考响应函数可以从磁性粒子的空间分布以数学方式确定测量值。 最后，通过参考响应函数从测量值重建磁性粒子的空间分布。

公开(公告)号：US07680608B2

公开(公告)日：2010-03-16

申请号：US11721062

申请日：2005-12-05

申请人： Tim Nielsen ,  Bernhard Gleich ,  Jurgen Weizenecker

发明人： Tim Nielsen ,  Bernhard Gleich ,  Jurgen Weizenecker

IPC分类号： G01N31/00 ,  G01C25/00

CPC分类号： A61B5/05 ,  A61B5/0515 ,  A61B5/7257

摘要： The invention relates to a method of determining a spatial distribution of magnetic particles in an examination area, in which a magnetic field is generated which has a first part-region having a relatively low magnetic field strength and a second part-region having a relatively high magnetic field strength. The position of the two part-regions is changed, as a result of which the magnetization in the examination area changes, and real measured values which depend on the change in magnetization are recorded. A dependence distribution which depends on a spatial distribution of magnetic particles is then determined such that a sum which comprises as summands a) the difference of the real measured values from fictitious measured values which are determined by applying a transfer function to the dependence distribution, and b) the product of a regularization parameter and of a regularization value which is determined by applying the regularization functional to the dependence distribution, is minimized. Finally, the spatial distribution of magnetic particles is determined by means of the determined dependence distribution.

摘要翻译： 本发明涉及一种确定检测区域中的磁性颗粒的空间分布的方法，其中产生磁场，其具有磁场强度较低的第一部分区域和具有较高磁场强度的第二部分区域 磁场强度。 两部分区域的位置发生变化，因此检查区域的磁化强度变化，并且记录取决于磁化变化的实测值。 然后确定依赖于磁性颗粒的空间分布的依赖性分布，使得包括作为求和的和a）通过将依赖分布应用传递函数确定的实际测量值与虚构测量值的差异，以及 b）将正则化参数和通过对依赖分布应用正则化函数确定的正则化值的乘积最小化。 最后，通过确定的依赖分布来确定磁性颗粒的空间分布。

公开(公告)号：US20090240135A1

公开(公告)日：2009-09-24

申请号：US11721371

申请日：2005-12-06

申请人： Bernhard Gleich ,  Jürgen Weizenecker ,  Tim Nielsen

发明人： Bernhard Gleich ,  Jürgen Weizenecker ,  Tim Nielsen

IPC分类号： A61B5/05

CPC分类号： A61B5/0515 ,  A61B5/05 ,  A61B5/7257

摘要： The invention relates to a method of determining a spatial distribution of magnetic particles in an examination zone, in which a magnetic field is generated that has a first sub-zone of lower magnetic field strength and a second sub-zone of higher magnetic field strength. The positions of the two sub-zones are changed, as a result of which the magnetization in the examination zone changes. Measured values that depend on the change in magnetization are acquired. A reference response function by means of which measured values can be determined mathematically from a spatial distribution of magnetic particles is then determined by means of at least extensive magnetic specimen distribution. Finally, the spatial distribution of magnetic particles is reconstructed from the measured values by means of the reference response function.

摘要翻译： 本发明涉及一种确定检测区中的磁性颗粒的空间分布的方法，其中产生具有较低磁场强度的第一子区和较高磁场强度的第二子区的磁场。 两个子区域的位置改变，结果是检查区域的磁化改变。 取决于磁化变化的测量值。 然后可以借助于至少广泛的磁性样本分布来确定参考响应函数，通过该参考响应函数可以从磁性粒子的空间分布以数学方式确定测量值。 最后，通过参考响应函数从测量值重建磁性粒子的空间分布。

公开(公告)号：US20090234588A1

公开(公告)日：2009-09-17

申请号：US11721062

申请日：2005-12-05

申请人： Tim Nielsen ,  Bernhard Gleich ,  Jürgen Weizenecker

发明人： Tim Nielsen ,  Bernhard Gleich ,  Jürgen Weizenecker

IPC分类号： G06F19/00

CPC分类号： A61B5/05 ,  A61B5/0515 ,  A61B5/7257

摘要： The invention relates to a method of determining a spatial distribution of magnetic particles in an examination area, in which a magnetic field is generated which has a first part-region having a relatively low magnetic field strength and a second part-region having a relatively high magnetic field strength. The position of the two part-regions is changed, as a result of which the magnetization in the examination area changes, and real measured values which depend on the change in magnetization are recorded. A dependence distribution which depends on a spatial distribution of magnetic particles is then determined such that a sum which comprises as summands a) the difference of the real measured values from fictitious measured values which are determined by applying a transfer function to the dependence distribution, and b) the product of a regularization parameter and of a regularization value which is determined by applying the regularization functional to the dependence distribution, is minimized. Finally, the spatial distribution of magnetic particles is determined by means of the determined dependence distribution.

摘要翻译： 本发明涉及一种确定检测区域中的磁性颗粒的空间分布的方法，其中产生磁场，其具有磁场强度较低的第一部分区域和具有较高磁场强度的第二部分区域 磁场强度。 两部分区域的位置发生变化，因此检查区域的磁化强度变化，并且记录取决于磁化变化的实测值。 然后确定依赖于磁性颗粒的空间分布的依赖性分布，使得包括作为求和的和a）通过将依赖分布应用传递函数确定的实际测量值与虚构测量值的差异，以及 b）将正则化参数和通过对依赖分布应用正则化函数确定的正则化值的乘积最小化。 最后，通过确定的依赖分布来确定磁性颗粒的空间分布。

公开(公告)号：US20070229080A1

公开(公告)日：2007-10-04

申请号：US11568125

申请日：2005-03-30

申请人： Steffen Weiss ,  Tim Nielsen

发明人： Steffen Weiss ,  Tim Nielsen

IPC分类号： G01R33/465 ,  A61B5/05

CPC分类号： G01R33/287 ,  G01R33/34084 ,  G01R33/36 ,  G01R33/3621 ,  G01R33/3692

摘要： A receive coil (46, 46′, 46″) receiving a magnetic resonance signal includes an optical resonant cavity (82, 82′, 82″) having an electro-optically active medium (90, 90′, 90″). A radio frequency antenna (80, 80′, 80″) is coupled with the electro-optically active medium such that reception of the magnetic resonance signal by the radio frequency antenna modulates an optical characteristic of the optical resonant cavity. An interventional instrument (48) is adapted for partial insertion into an associated imaging subject (16). The radio frequency antenna and the optical resonant cavity are disposed on a portion of the interventional instrument that is inserted into the associated imaging subject. At least one optical fiber (52, 54) is optically coupled with the optical resonant cavity. An end of the at least one optical fiber extends outside of the associated imaging subject when the interventional instrument is partially inserted.

摘要翻译： 接收磁共振信号的接收线圈（46,46'，46“）包括具有电光活性介质（90,90'，90”）的光学谐振腔（82,82'，82“）， 。 射频天线（80,80'，80“）与电光活性介质耦合，使得由射频天线接收磁共振信号调制光谐振腔的光学特性。 介入器械（48）适于部分地插入到相关联的成像对象（16）中。 无线电频率天线和光学谐振腔被布置在插入到相关联的成像对象中的介入仪器的一部分上。 至少一个光纤（52,54）与光学谐振腔光学耦合。 当介入器械被部分地插入时，至少一个光纤的一端延伸到相关的成像对象的外部。

公开(公告)号：US08406840B2

公开(公告)日：2013-03-26

申请号：US12066561

申请日：2006-09-07

申请人： Tim Nielsen ,  Thomas Koehler

发明人： Tim Nielsen ,  Thomas Koehler

IPC分类号： A61B5/00

CPC分类号： A61B5/0073 ,  A61B5/14551 ,  A61B5/1495

摘要： In optical tomography, a calibration of the data may be necessary for image reconstruction. According to an exemplary embodiment of the present invention, the object of interest is used for calibration, wherein the image data is acquired during a highly oxygenated phase of the object of interest and wherein the calibration data is acquired during a low oxygenated phase of the object of interest. This may provide for an improved calibration, resulting in improved image quality.

摘要翻译： 在光学层析成像中，图像重构可能需要校准数据。 根据本发明的示例性实施例，感兴趣的对象被用于校准，其中在感兴趣对象的高度充氧阶段期间获取图像数据，并且其中在对象的低氧合期期间获取校准数据 出于兴趣。 这可以提供改进的校准，导致改善的图像质量。

公开(公告)号：US20100238441A1

公开(公告)日：2010-09-23

申请号：US12682939

申请日：2008-10-13

申请人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/49 ,  G01N21/00

CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

摘要翻译： 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。