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    Process for the enzymatic reduction of enoates
    1.
    发明授权
    Process for the enzymatic reduction of enoates 有权
    烯酸酶的还原方法

    公开(公告)号：US08709767B2

    公开(公告)日：2014-04-29

    申请号：US13658328

    申请日：2012-10-23

    申请人： Stephan Maurer ,  Bernhard Hauer ,  Melanie Bonnekessel ,  Kurt Faber ,  Clemens Stückler

    发明人： Stephan Maurer ,  Bernhard Hauer ,  Melanie Bonnekessel ,  Kurt Faber ,  Clemens Stückler

    IPC分类号： C12P7/24 ,  C12P7/40 ,  C12P7/26

    CPC分类号： C12P7/24 ,  C12N9/001 ,  C12P7/22 ,  C12P7/26 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/62 ,  C12P17/10 ,  C12Y103/01031

    摘要： A process for the enzymatic reduction of an enoate (1) wherein the C═C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, in which A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R═H or optionally substituted C1-C6-alkyl radical, R1, R2 and R3 are independently of one another H, —O—C1-C6-alkyl, —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1 is linked to R3 so as to become part of a 4-8-membered cycle, or R1 is linked to R so as to become part of a 4-8-membered cycle, with the proviso that R1, R2 and R3 may not be identical.

    摘要翻译： 在酸酐（1）的酶促还原方法中，其中将enoate（1）的C = C键在烯醇还原酶和可氧化共底物（2）存在下立体选择性氢化， 的NAD（P）H，其中A是酮基（-CRO），醛基（-CHO），羧基（-COOR），R = H或任选取代的C 1 -C 6 - 烷基，R 1 ，R2和R3彼此独立地为H，-O-C1-C6-烷基，-O-W，其中W为羟基保护基，可被取代的C1-C6-烷基，C2-C6-烯基，羧基 或任选取代的碳 - 或杂环芳族或非芳族基团，或者R 1，R 2和R 3中的一个是-OH基团，或R 1与R 3连接，以便成为4-8元环的一部分，或 R1与R连接成为4-8元环的一部分，条件是R1，R2和R3可能不相同。

    PROCESS FOR THE ENZYMATIC REDUCTION OF ENOATES
    2.
    发明申请
    PROCESS FOR THE ENZYMATIC REDUCTION OF ENOATES 有权
    减少臭氧的方法

    公开(公告)号：US20130045513A1

    公开(公告)日：2013-02-21

    申请号：US13658328

    申请日：2012-10-23

    申请人： Stephan Maurer ,  Bernhard Hauer ,  Melanie Bonnekessel ,  Kurt Faber ,  Clemens Stückler

    发明人： Stephan Maurer ,  Bernhard Hauer ,  Melanie Bonnekessel ,  Kurt Faber ,  Clemens Stückler

    IPC分类号： C12P17/10 ,  C12P7/42 ,  C12P7/38 ,  C12P7/44 ,  C12P7/24 ,  C12P7/26

    CPC分类号： C12P7/24 ,  C12N9/001 ,  C12P7/22 ,  C12P7/26 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/62 ,  C12P17/10 ,  C12Y103/01031

    摘要： A process for the enzymatic reduction of an enoate (1) wherein the C═C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, a. b. in which c. A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R═H or optionally substituted C1-C6-alkyl radical, d. R1, R2 and R3 are independently of one another H, —O—C1-C6-alkyl, —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1 is linked to R3 so as to become part of a 4-8-membered cycle, or R1 is linked to R so as to become part of a 4-8-membered cycle, with the proviso that R1, R2 and R3 may not be identical.

    摘要翻译： 在酸酐（1）的酶促还原方法中，其中将enoate（1）的C = C键在烯醇还原酶和可氧化共底物（2）存在下立体选择性氢化，所述方法是游离的 的NAD（P）H，a。 b。 其中c。 A是酮基（-CRO），醛基（-CHO），羧基（-COOR），R = H或任选取代的C 1 -C 6烷基，d。 R 1，R 2和R 3彼此独立地为H，-O-C 1 -C 6 - 烷基，-O-W，其中W =羟基保护基，可被取代的C 1 -C 6烷基，C 2 -C 6 - 烯基， 羧基或任选取代的碳 - 或杂环芳族或非芳族基团，或者R 1，R 2和R 3中的一个是-OH基团，或R 1与R 3连接，以便成为4-8元环的一部分， 或R 1与R连接，以便成为4-8元环的一部分，条件是R 1，R 2和R 3可以不相同。