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公开(公告)号：US5716644A
公开(公告)日：1998-02-10
申请号：US478502
申请日：1995-06-07
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K9/51 , A61K9/52 , A61K38/17 , A61K38/18 , A61K38/22 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/42 , A61P7/00
CPC分类号： B82Y5/00 , A61K38/1816 , A61K9/0019 , A61K9/1611 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5052 , A61K9/5153 , A61K9/5169 , A61K47/02 , A61K47/26 , A61K9/1694 , Y10S514/963 , Y10S514/965
摘要： A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, aggregation-stabilized EPO, wherein said particles are dispersed within the biocompatible polymer. The method of the invention for producing a composition for the sustained release of biologically active EPO, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, aggregation-stabilized EPO in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said EPO particles. The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated erythropoietin in a subject for a sustained period. In this method, a subject is administered an effective dose of the sustained release composition of the present invention.
摘要翻译： 用于持续释放非聚集的，生物活性的促红细胞生成素（EPO）的组合物和形成和使用所述组合物的方法。 本发明的持续释放组合物包含生物相容性聚合物的聚合物基质和生物活性聚集稳定的EPO颗粒，其中所述颗粒分散在生物相容性聚合物内。 用于制备用于持续释放生物活性EPO的组合物的本发明的方法包括将生物相容性聚合物溶解在聚合物溶剂中以形成聚合物溶液，将生物活性聚集稳定的EPO的颗粒分散在聚合物溶液中，然后 固化聚合物以形成含有所述EPO颗粒的分散体的聚合物基质。 使用本发明组合物的方法是在持续时间内在受试者中提供治疗有效的血液中生物活性，非聚集的促红细胞生成素的方法。 在该方法中，给予受试者有效剂量的本发明的持续释放组合物。
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公开(公告)号：US5674534A
公开(公告)日：1997-10-07
申请号：US483318
申请日：1995-06-07
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K9/51 , A61K9/52 , A61K38/17 , A61K38/18 , A61K38/22 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/42 , B01J13/02 , B32B5/16
CPC分类号： A61K9/1611 , A61K38/1816 , A61K9/0019 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5052 , A61K9/5153 , A61K9/5169 , A61K47/02 , A61K47/26 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, aggregation-stabilized EPO, wherein said particles are dispersed within the biocompatible polymer. The method of the invention for producing a composition for the sustained release of biologically active EPO, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, aggregation-stabilized EPO in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said EPO particles. The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated erythropoietin in a subject for a sustained period. In this method, a subject is administered an effective dose of the sustained release composition of the present invention.
摘要翻译： 用于持续释放非聚集的，生物活性的促红细胞生成素（EPO）的组合物和形成和使用所述组合物的方法。 本发明的持续释放组合物包含生物相容性聚合物的聚合物基质和生物活性聚集稳定的EPO颗粒，其中所述颗粒分散在生物相容性聚合物内。 用于制备用于持续释放生物活性EPO的组合物的本发明的方法包括将生物相容性聚合物溶解在聚合物溶剂中以形成聚合物溶液，将生物活性聚集稳定的EPO的颗粒分散在聚合物溶液中，然后 固化聚合物以形成含有所述EPO颗粒的分散体的聚合物基质。 使用本发明组合物的方法是在持续时间内在受试者中提供治疗有效的血液中生物活性，非聚集的促红细胞生成素的方法。 在该方法中，给予受试者有效剂量的本发明的持续释放组合物。
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