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公开(公告)号：US08916135B2
公开(公告)日：2014-12-23
申请号：US12197061
申请日：2008-08-22
CPC分类号： C08F8/42 , A61B5/055 , A61K47/58 , A61K49/00 , A61K49/0054 , A61K49/12 , A61K49/1818 , A61K49/1854 , B82Y5/00 , C07B2200/11 , C07F5/003 , C08F122/36
摘要： The present disclosure is directed generally to lanthanide nanoparticle conjugates, such as gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, conjugation to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
摘要翻译： 本公开通常涉及镧系元素纳米颗粒缀合物，例如钆纳米颗粒缀合物，包括聚合物的纳米颗粒缀合物，与靶向剂和治疗剂的缀合，以及它们在靶向，治疗和/或成像患者体内疾病状态的用途。
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公开(公告)号：US20090060840A1
公开(公告)日：2009-03-05
申请号：US12197061
申请日：2008-08-22
CPC分类号： C08F8/42 , A61B5/055 , A61K47/58 , A61K49/00 , A61K49/0054 , A61K49/12 , A61K49/1818 , A61K49/1854 , B82Y5/00 , C07B2200/11 , C07F5/003 , C08F122/36
摘要： The present disclosure is directed generally to lanthanide nanoparticle conjugates, such as gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, conjugation to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
摘要翻译： 本公开通常涉及镧系元素纳米颗粒缀合物，例如钆纳米颗粒缀合物，包括聚合物的纳米颗粒缀合物，与靶向剂和治疗剂的缀合，以及它们在靶向，治疗和/或成像患者体内疾病状态的用途。
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公开(公告)号：US20090111135A1
公开(公告)日：2009-04-30
申请号：US12260885
申请日：2008-10-29
申请人： Randy Ringold , Renee Parker , Douglas H. Thamm
发明人： Randy Ringold , Renee Parker , Douglas H. Thamm
IPC分类号： C12Q1/48
CPC分类号： G01N33/57407
摘要： The disclosure relates to a method for detecting hemangiosarcoma in canines. The method includes the steps of: (1) obtaining a quantity of blood from the subject canine; (2) separating the quantity of blood into a serum portion and a non-serum portion; (3) contacting the serum portion of the blood with a detector to detect presence of an amount of Thymidine Kinase (TK); and (4) detecting the level of TK in serum and determining whether TK is present in amounts of about 8 units/mL or greater.
摘要翻译： 本公开涉及一种用于检测犬科血管肉瘤的方法。 该方法包括以下步骤：（1）从本犬获得一定量的血液; （2）将血液量分为血清部分和非血清部分; （3）使血清部分与检测器接触以检测一定量的胸苷激酶（TK）的存在; 和（4）检测血清中TK的水平，并确定TK是否以约8单位/ mL或更高的量存在。
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4.发明申请公开(公告)号：US20120156690A1
公开(公告)日：2012-06-21
申请号：US13323670
申请日：2011-12-12
申请人： Randy Ringold , Renee Parker , Douglas H. Thamm
发明人： Randy Ringold , Renee Parker , Douglas H. Thamm
IPC分类号： C12Q1/48 , G01N33/574
CPC分类号： G01N33/57407
摘要： The disclosure relates to a method for detecting hemangiosarcoma in canines. The method includes the steps of: (1) obtaining a quantity of blood from the subject canine; (2) separating the quantity of blood into a serum portion and a non-serum portion; (3) contacting the serum portion of the blood with a detector to detect presence of an amount of Thymidine Kinase (TK); and (4) detecting the level of TK in serum and determining whether TK is present in amounts of about 8 units/L or greater.
摘要翻译： 本公开涉及一种用于检测犬科血管肉瘤的方法。 该方法包括以下步骤：（1）从本犬获得一定量的血液; （2）将血液量分为血清部分和非血清部分; （3）使血清部分与检测器接触以检测一定量的胸苷激酶（TK）的存在; 和（4）检测血清中TK的水平，并确定TK是否以约8单位/ L或更高的量存在。
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5.发明授权Method for diagnosing hemangiosarcoma in canine using detection of thymidine kinase activity 有权使用胸苷激酶活性检测来诊断犬血管肉瘤的方法公开(公告)号：US08097432B2
公开(公告)日：2012-01-17
申请号：US12260885
申请日：2008-10-29
申请人： Randy Ringold , Renee Parker , Douglas H. Thamm
发明人： Randy Ringold , Renee Parker , Douglas H. Thamm
IPC分类号： C12Q1/48
CPC分类号： G01N33/57407
摘要： The disclosure relates to a method for detecting hemangiosarcoma in canines. The method includes the steps of: (1) obtaining a quantity of blood from the subject canine; (2) separating the quantity of blood into a serum portion and a non-serum portion; (3) contacting the serum portion of the blood with a detector to detect presence of an amount of Thymidine Kinase (TK); and (4) detecting the level of TK in serum and determining whether TK is present in amounts of about 8 units/mL or greater.
摘要翻译： 本公开涉及一种用于检测犬科血管肉瘤的方法。 该方法包括以下步骤：（1）从本犬获得一定量的血液; （2）将血液量分为血清部分和非血清部分; （3）使血清部分与检测器接触以检测一定量的胸苷激酶（TK）的存在; 和（4）检测血清中TK的水平，并确定TK是否以约8单位/ mL或更高的量存在。
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