公开(公告)号：US4261977A

公开(公告)日：1981-04-14

申请号：US937736

申请日：1978-08-29

Applicant: Stephen J. Box ,  John D. Hood

Inventor： Stephen J. Box ,  John D. Hood

IPC: C07D477/00 ,  A61K31/397 ,  A61K31/40 ,  A61K35/74 ,  A61K36/06 ,  A61P31/04 ,  C07D477/20 ,  C07G11/00 ,  C12N9/99 ,  C12P1/06 ,  C12P17/18 ,  A61K35/00

CPC classification number: C07D477/20 ,  C12P17/184 ,  C12R1/58

Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained from many organisms so that it shows a synergistic antibacterical effect when combined with .beta.-lactam antibiotics.

Abstract translation: 本文定义的新型抗生素MM 17880可以从橄榄油链霉菌和相关生物的菌株的培养获得。 除了是有效的抗菌剂外，MM 17880及其盐抑制从许多生物体获得的β-内酰胺酶，因此当与β-内酰胺抗生素组合时，其显示出协同的抗菌作用。

公开(公告)号：US4072569A

公开(公告)日：1978-02-07

申请号：US726135

申请日：1976-09-24

Applicant: Stephen J. Box

Inventor： Stephen J. Box

IPC: C12P7/46 ,  C07D503/00 ,  C12P17/18 ,  C12R1/465 ,  C12D9/14

CPC classification number: C07D503/00 ,  C12P17/188 ,  Y10S435/803 ,  Y10S435/852 ,  Y10S435/886

Abstract: Clavulanic acid and its salts may be produced by cultivating a strain of Streptomyces jumonjinensis.

Abstract translation: 克拉维酸及其盐可以通过培养链霉菌（Streptomyces jumonjinensis）菌株来生产。

公开(公告)号：US4179498A

公开(公告)日：1979-12-18

申请号：US717336

申请日：1976-08-24

Applicant: Stephen J. Box ,  John D. Hood

Inventor： Stephen J. Box ,  John D. Hood

IPC: C07D477/20 ,  C12P17/18 ,  A61K25/00

CPC classification number: C07D477/20 ,  C12P17/184 ,  C12R1/58 ,  Y10S435/902

Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained from many organisms so that it shows a synergistic antibacterial effect when combined with .beta.-lactam antibiotics.

Abstract translation: 本文定义的新型抗生素MM 17880可以从橄榄油链霉菌和相关生物的菌株的培养获得。 除了有效的抗菌剂外，MM 17880及其盐抑制从许多生物体获得的β-内酰胺酶，因此当与β-内酰胺抗生素结合时，其显示出协同的抗菌作用。

公开(公告)号：US4163051A

公开(公告)日：1979-07-31

申请号：US725864

申请日：1976-09-23

Applicant: Stephen J. Box ,  John D. Hood

Inventor： Stephen J. Box ,  John D. Hood

IPC: C07D477/20 ,  A61K35/00

CPC classification number: C07D477/20

Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained from may organisms so that it shows a synergistic antibacterial effect when combined with .beta.-lactam antibiotics.

Abstract translation: 本文定义的新型抗生素MM 17880可以从橄榄油链霉菌和相关生物的菌株的培养获得。 除了有效的抗菌剂外，MM 17880及其盐可抑制从有机体获得的β-内酰胺酶，以便与β-内酰胺抗生素组合时显示出协同的抗菌作用。

公开(公告)号：US4421760A

公开(公告)日：1983-12-20

申请号：US274464

申请日：1981-06-17

Applicant: Stephen J. Box

Inventor： Stephen J. Box

IPC: C12N1/20 ,  A61K31/397 ,  A61K31/40 ,  A61P31/04 ,  C07D477/00 ,  C07D477/20 ,  C12P17/18 ,  C12R1/465 ,  C12R1/58 ,  C07D487/04

CPC classification number: C07D477/20 ,  C12P17/184 ,  C12R1/58

Abstract: The compound of the formula (VI): ##STR1## pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof, are useful for their antibacterial activity and for their .beta.-lactamase inhibitory activity. They may be combined in a synergistically effective amount with a penicillin or cephalosporin for the treatment of bacterial infections in humans and animals.

Abstract translation: 式（VI）的化合物：其药学上可接受的盐和药学上可接受的酯可用于其抗菌活性和β-内酰胺酶抑制活性。 它们可以以协同有效量与青霉素或头孢菌素组合用于治疗人和动物的细菌感染。

公开(公告)号：US4221870A

公开(公告)日：1980-09-09

申请号：US916768

申请日：1978-06-19

Applicant: Stephen J. Box

Inventor： Stephen J. Box

IPC: C12P17/18

CPC classification number: C12R1/465 ,  C12P17/184 ,  Y10S435/886

Abstract: This invention provides a process for the preparation of salts of the .beta.-lactamase inhibitory antibiotics MM4550A, MM13902 and MM17880, which are the compounds of the formulae (I)-(III), respectively: ##STR1## which process comprises cultivating a strain of Streptomyces gedanensis and isolating a salt of at least one of MM4550A, MM13902 and MM17880.

Abstract translation: 本发明提供了分别制备式（I） - （III）化合物的β-内酰胺酶抑制性抗生素MM4550A，MM13902和MM17880的盐的方法： （III），该方法包括培养一种链霉菌（Streptomyces gedanensis）菌株并分离MM4550A，MM13902和MM17880中的至少一种的盐。

公开(公告)号：US4162304A

公开(公告)日：1979-07-24

申请号：US725677

申请日：1976-09-22

Applicant: Stephen J. Box ,  John D. Hood

Inventor： Stephen J. Box ,  John D. Hood

IPC: C07D477/20 ,  A61K35/00

CPC classification number: C07D477/20

Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained fromm many organisms so that it shows a synergistic antibacterial effect when combined with .beta.-lactam antibiotics.

Abstract translation: 本文定义的新型抗生素MM 17880可以从橄榄油链霉菌和相关生物的菌株的培养获得。 除了有效的抗菌剂外，MM 17880及其盐抑制了许多生物体获得的β-内酰胺酶，因此当与β-内酰胺抗生素结合时，其显示出协同的抗菌作用。