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公开(公告)号:US20080254487A1
公开(公告)日:2008-10-16
申请号:US10586318
申请日:2005-01-14
申请人: Stephen J. Klaus , David Y. Liu , Irina Aizman
发明人: Stephen J. Klaus , David Y. Liu , Irina Aizman
IPC分类号: G01N33/566 , C07H3/00 , C12Q1/02
CPC分类号: G01N33/74 , A61K31/737 , G01N2500/02
摘要: The present invention provides compounds and agents that modulate CTGF-mediated cell adhesion and/or binding of CTGF to cells. The invention further provides assays that may be used to identify additional modulators of CTGF-mediated cell adhesion and CTGF binding to cells, and assays that may be used to identify compounds or agents that modulate interaction of CTGF with HSPGs.
摘要翻译: 本发明提供调节CTGF介导的细胞粘附和/或CTGF与细胞结合的化合物和试剂。 本发明进一步提供可用于鉴定CTGF介导的细胞粘附和CTGF与细胞结合的其它调节剂的测定法,以及可用于鉴定调节CTGF与HSPG相互作用的化合物或试剂的测定法。
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公开(公告)号:US20070293575A1
公开(公告)日:2007-12-20
申请号:US11455202
申请日:2006-06-15
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K31/198
CPC分类号: A61K31/47
摘要: The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.
摘要翻译: 本发明涉及治疗癌症贫血的方法和化合物。 特别地,在具有癌症的受试者中治疗癌症的贫血的方法和增加网织红细胞的方法,增加血红蛋白,增加血细胞比容,以及增加患有贫血的受试者的红细胞计数,其中这些受试者对重组人治疗是难以治疗的 红细胞生成素(EPO)包括在本文中。
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公开(公告)号:US08530404B2
公开(公告)日:2013-09-10
申请号:US11455199
申请日:2006-06-15
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A01N61/00
CPC分类号: A61K31/4745 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/63 , A61K38/16
摘要: The invention relates to methods and compounds for treating or preventing cancer. Methods for treating or preventing cancer, for inhibiting tumor growth, reducing tumor volume, inhibiting tumor progression, inhibiting metastasis, and improving survival are provided herein.
摘要翻译: 本发明涉及治疗或预防癌症的方法和化合物。 本文提供了治疗或预防癌症,抑制肿瘤生长,减少肿瘤体积,抑制肿瘤进展,抑制转移和改善生存的方法。
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公开(公告)号:US20110015223A1
公开(公告)日:2011-01-20
申请号:US12806589
申请日:2010-08-16
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K31/472 , A61P7/06
CPC分类号: A61K31/47
摘要: The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.
摘要翻译: 本发明涉及治疗癌症贫血的方法和化合物。 特别地,在具有癌症的受试者中治疗癌症的贫血的方法和增加网织红细胞的方法,增加血红蛋白,增加血细胞比容,以及增加患有贫血的受试者的红细胞计数,其中这些受试者对重组人治疗是难以治疗的 红细胞生成素(EPO)包括在本文中。
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5.
公开(公告)号:US20100204269A1
公开(公告)日:2010-08-12
申请号:US12798856
申请日:2010-04-13
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K31/472
CPC分类号: A61K45/06 , A61K31/472
摘要: The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
摘要翻译: 本发明涉及治疗化疗诱发性贫血的方法和化合物。 特别地,本文包括在用重组人促红细胞生成素治疗难治的受试者中治疗化疗诱导的贫血的方法。
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公开(公告)号:US07713986B2
公开(公告)日:2010-05-11
申请号:US11455200
申请日:2006-06-15
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K31/505
CPC分类号: A61K45/06 , A61K31/472
摘要: The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
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7.
公开(公告)号:US20070292433A1
公开(公告)日:2007-12-20
申请号:US11455200
申请日:2006-06-15
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K39/395 , A61K38/46 , A61K31/7072 , A61K31/704 , A61K31/66 , A61K31/56 , A61K31/525 , A61K31/522 , A61K31/454 , A61K31/337
CPC分类号: A61K45/06 , A61K31/472
摘要: The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
摘要翻译: 本发明涉及治疗化疗诱发性贫血的方法和化合物。 特别地,本文包括在用重组人促红细胞生成素治疗难治的受试者中治疗化疗诱导的贫血的方法。
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公开(公告)号:US08314059B2
公开(公告)日:2012-11-20
申请号:US12802373
申请日:2010-06-03
申请人: Allan Flyvbjerg , Guangjie Guo , David Y. Liu , Thomas B. Neff , Noelynn A. Oliver , William R. Usinger , Qingjian Wang
发明人: Allan Flyvbjerg , Guangjie Guo , David Y. Liu , Thomas B. Neff , Noelynn A. Oliver , William R. Usinger , Qingjian Wang
CPC分类号: A61K38/556 , A61K31/00 , A61K39/395 , A61K2039/505 , C07K16/22 , A61K2300/00
摘要: The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.
摘要翻译: 本发明涉及用于治疗糖尿病肾病的特异性早期方面和晚期方面的方法和化合物。 还提供了用于治疗与早期和晚期糖尿病肾病相关的各种生理特征的方法和化合物。
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9.
公开(公告)号:US06589954B1
公开(公告)日:2003-07-08
申请号:US09316761
申请日:1999-05-21
IPC分类号: A61K31495
CPC分类号: C07D401/06 , C07D209/08 , C07D209/24 , C07D235/06 , C07D401/14 , C07D403/06 , C07D471/04
摘要: Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful in treating cardiac conditions associated with heart failure and in treating conditions characterized by proinflammation.
摘要翻译: 在5或6位被取代基的吲哚,苯并咪唑和苯并三唑与包含通过哌嗪环连接到所述吲哚,苯并咪唑或苯并三唑的芳族部分的取代基可用于治疗与心力衰竭相关的心脏病症和治疗以促炎症为特征的病症 。
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公开(公告)号:US07268139B2
公开(公告)日:2007-09-11
申请号:US10651934
申请日:2003-08-29
IPC分类号: A61K31/497 , A61K31/445 , A61K31/415 , A61K31/38 , A61K31/385
CPC分类号: A61K31/404 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/517 , A61K31/53
摘要: The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxillary reconstruction, mandibular reconstruction or tooth extraction, enhancing long bone extension, enhancing prosthetic ingrowth, and increasing bone synostosis by administering a p38 MAP kinase inhibitor.
摘要翻译: 本发明涉及通过施用p38MAP激酶抑制剂的骨愈合方法。 本发明涉及治疗骨折,骨疾病,骨移植,特别是增强面部重建后的骨愈合,上颌骨重建,下颌骨重建或拔牙,增强长骨延伸,增强假体向内生长以及增加骨愈合的方法,通过施用 p38 MAP激酶抑制剂。
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