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公开(公告)号:US20080254487A1
公开(公告)日:2008-10-16
申请号:US10586318
申请日:2005-01-14
申请人: Stephen J. Klaus , David Y. Liu , Irina Aizman
发明人: Stephen J. Klaus , David Y. Liu , Irina Aizman
IPC分类号: G01N33/566 , C07H3/00 , C12Q1/02
CPC分类号: G01N33/74 , A61K31/737 , G01N2500/02
摘要: The present invention provides compounds and agents that modulate CTGF-mediated cell adhesion and/or binding of CTGF to cells. The invention further provides assays that may be used to identify additional modulators of CTGF-mediated cell adhesion and CTGF binding to cells, and assays that may be used to identify compounds or agents that modulate interaction of CTGF with HSPGs.
摘要翻译: 本发明提供调节CTGF介导的细胞粘附和/或CTGF与细胞结合的化合物和试剂。 本发明进一步提供可用于鉴定CTGF介导的细胞粘附和CTGF与细胞结合的其它调节剂的测定法,以及可用于鉴定调节CTGF与HSPG相互作用的化合物或试剂的测定法。
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公开(公告)号:US20070293575A1
公开(公告)日:2007-12-20
申请号:US11455202
申请日:2006-06-15
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K31/198
CPC分类号: A61K31/47
摘要: The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.
摘要翻译: 本发明涉及治疗癌症贫血的方法和化合物。 特别地,在具有癌症的受试者中治疗癌症的贫血的方法和增加网织红细胞的方法,增加血红蛋白,增加血细胞比容,以及增加患有贫血的受试者的红细胞计数,其中这些受试者对重组人治疗是难以治疗的 红细胞生成素(EPO)包括在本文中。
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公开(公告)号:US08530404B2
公开(公告)日:2013-09-10
申请号:US11455199
申请日:2006-06-15
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A01N61/00
CPC分类号: A61K31/4745 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/63 , A61K38/16
摘要: The invention relates to methods and compounds for treating or preventing cancer. Methods for treating or preventing cancer, for inhibiting tumor growth, reducing tumor volume, inhibiting tumor progression, inhibiting metastasis, and improving survival are provided herein.
摘要翻译: 本发明涉及治疗或预防癌症的方法和化合物。 本文提供了治疗或预防癌症,抑制肿瘤生长,减少肿瘤体积,抑制肿瘤进展,抑制转移和改善生存的方法。
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公开(公告)号:US20110015223A1
公开(公告)日:2011-01-20
申请号:US12806589
申请日:2010-08-16
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K31/472 , A61P7/06
CPC分类号: A61K31/47
摘要: The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.
摘要翻译: 本发明涉及治疗癌症贫血的方法和化合物。 特别地,在具有癌症的受试者中治疗癌症的贫血的方法和增加网织红细胞的方法,增加血红蛋白,增加血细胞比容,以及增加患有贫血的受试者的红细胞计数,其中这些受试者对重组人治疗是难以治疗的 红细胞生成素(EPO)包括在本文中。
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5.
公开(公告)号:US20100204269A1
公开(公告)日:2010-08-12
申请号:US12798856
申请日:2010-04-13
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K31/472
CPC分类号: A61K45/06 , A61K31/472
摘要: The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
摘要翻译: 本发明涉及治疗化疗诱发性贫血的方法和化合物。 特别地,本文包括在用重组人促红细胞生成素治疗难治的受试者中治疗化疗诱导的贫血的方法。
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公开(公告)号:US07713986B2
公开(公告)日:2010-05-11
申请号:US11455200
申请日:2006-06-15
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K31/505
CPC分类号: A61K45/06 , A61K31/472
摘要: The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
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7.
公开(公告)号:US20070292433A1
公开(公告)日:2007-12-20
申请号:US11455200
申请日:2006-06-15
申请人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
发明人: Todd W. Seeley , David Y. Liu , Stephen J. Klaus
IPC分类号: A61K39/395 , A61K38/46 , A61K31/7072 , A61K31/704 , A61K31/66 , A61K31/56 , A61K31/525 , A61K31/522 , A61K31/454 , A61K31/337
CPC分类号: A61K45/06 , A61K31/472
摘要: The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
摘要翻译: 本发明涉及治疗化疗诱发性贫血的方法和化合物。 特别地,本文包括在用重组人促红细胞生成素治疗难治的受试者中治疗化疗诱导的贫血的方法。
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公开(公告)号:US09775902B2
公开(公告)日:2017-10-03
申请号:US13180262
申请日:2011-07-11
IPC分类号: A61K31/121 , A61K31/194 , A61K45/06 , A61K38/49
CPC分类号: A61K45/06 , A61K31/121 , A61K31/194 , A61K38/49 , A61K2300/00
摘要: The present invention relates to methods and agents useful for the treatment of stroke, including ischemic stroke and hemorrhagic stroke. In particular, methods and agents for treating stroke in a subject are provided, wherein the agent is administered prior to diagnosis of the stroke as an ischemic stroke or a hemorrhagic stroke.
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公开(公告)号:US08728468B2
公开(公告)日:2014-05-20
申请号:US13611494
申请日:2012-09-12
IPC分类号: A61K39/395
CPC分类号: A61K39/395 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K14/71 , C07K16/22 , G01N33/57438 , G01N2333/475
摘要: The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing melanoma tumor survival, expansion, and metastasis. The invention also provides agents for use in the methods, particularly agents that reduce the level or activity of connective tissue growth factor (CTGF).
摘要翻译: 本发明提供了减少肿瘤存活,扩张和转移的方法。 特别地,本发明提供了减少黑素瘤肿瘤存活,扩张和转移的方法。 本发明还提供用于该方法的试剂,特别是降低结缔组织生长因子(CTGF)的水平或活性的试剂。
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公开(公告)号:US08604013B2
公开(公告)日:2013-12-10
申请号:US12804042
申请日:2010-07-12
申请人: Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
发明人: Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
CPC分类号: C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要: The present invention relates to methods for treating anemia in a subject having a low percent transferrin saturation by administering to the subject an effective amount of a compound that inhibits hypoxia-inducible factor prolyl hydroxylase activity.
摘要翻译: 本发明涉及通过向受试者施用有效量的抑制缺氧诱导因子脯氨酰羟化酶活性的化合物来治疗具有低转铁蛋白饱和度的受试者的贫血的方法。
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