Connective Tissue Growth Factor Signaling
    1.
    发明申请
    Connective Tissue Growth Factor Signaling 审中-公开
    结缔组织生长因子信号传导

    公开(公告)号:US20080254487A1

    公开(公告)日:2008-10-16

    申请号:US10586318

    申请日:2005-01-14

    IPC分类号: G01N33/566 C07H3/00 C12Q1/02

    摘要: The present invention provides compounds and agents that modulate CTGF-mediated cell adhesion and/or binding of CTGF to cells. The invention further provides assays that may be used to identify additional modulators of CTGF-mediated cell adhesion and CTGF binding to cells, and assays that may be used to identify compounds or agents that modulate interaction of CTGF with HSPGs.

    摘要翻译: 本发明提供调节CTGF​​介导的细胞粘附和/或CTGF与细胞结合的化合物和试剂。 本发明进一步提供可用于鉴定CTGF介导的细胞粘附和CTGF与细胞结合的其它调节剂的测定法,以及可用于鉴定调节CTGF​​与HSPG相互作用的化合物或试剂的测定法。

    Compounds and methods for treatment of cancer-related anemia
    2.
    发明申请
    Compounds and methods for treatment of cancer-related anemia 审中-公开
    用于治疗癌症相关性贫血的化合物和方法

    公开(公告)号:US20070293575A1

    公开(公告)日:2007-12-20

    申请号:US11455202

    申请日:2006-06-15

    IPC分类号: A61K31/198

    CPC分类号: A61K31/47

    摘要: The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.

    摘要翻译: 本发明涉及治疗癌症贫血的方法和化合物。 特别地,在具有癌症的受试者中治疗癌症的贫血的方法和增加网织红细胞的方法,增加血红蛋白,增加血细胞比容,以及增加患有贫血的受试者的红细胞计数,其中这些受试者对重组人治疗是难以治疗的 红细胞生成素(EPO)包括在本文中。

    Compounds and methods for treatment of cancer-related anemia
    4.
    发明申请
    Compounds and methods for treatment of cancer-related anemia 审中-公开
    用于治疗癌症相关性贫血的化合物和方法

    公开(公告)号:US20110015223A1

    公开(公告)日:2011-01-20

    申请号:US12806589

    申请日:2010-08-16

    IPC分类号: A61K31/472 A61P7/06

    CPC分类号: A61K31/47

    摘要: The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.

    摘要翻译: 本发明涉及治疗癌症贫血的方法和化合物。 特别地,在具有癌症的受试者中治疗癌症的贫血的方法和增加网织红细胞的方法,增加血红蛋白,增加血细胞比容,以及增加患有贫血的受试者的红细胞计数,其中这些受试者对重组人治疗是难以治疗的 红细胞生成素(EPO)包括在本文中。