公开(公告)号：US20080066332A1

公开(公告)日：2008-03-20

申请号：US11569907

申请日：2005-06-01

申请人： Stephen Metcalf ,  Ian Fletcher

发明人： Stephen Metcalf ,  Ian Fletcher

IPC分类号： G01B21/10 ,  G01C25/00

CPC分类号： G01B11/08

摘要： Method of detecting a potentially void inhaler can valve (30), which valve (30) is attached to a can (10) by a ferrule crimp (80), comprising the steps: placing the can (10) in a can jig (220) that is arranged to retain the can (10) at a predetermined measurement height with respect to a diameter measuring means (230), measuring the diameter of the ferrule crimp (80) at the predetermined height, and comparing the measured crimp diameter with a predefined interval of acceptance, and if the measured diameter is outside a predefined interval classifying the inhaler can valve (30) as potentially void. There is also provided a crimp diameter measuring device (200) comprising: a base (210), a diameter measuring means (230) supported by the base (210), and a can jig (220) supported by the base (210), the can jig (220) being arranged to retain a can (10) placed therein at a predetermined measurement height with respect to a diameter measuring means (230).

摘要翻译： 检测潜在空隙吸入器罐阀（30）的方法，所述阀（30）通过套圈压接（80）将所述阀（30）附接到罐（10），所述方法包括以下步骤：将罐（10）放置在罐夹具 ），其被设置成相对于直径测量装置（230）将罐（10）保持在预定的测量高度，测量套圈卷曲（80）在预定高度的直径，并将测量的卷曲直径与 预定的接受间隔，以及如果测量的直径在预定的间隔之外，则将吸入器罐阀（30）分类为潜在的空隙。 还提供了一种压接直径测量装置（200），包括：基座（210），由基座（210）支撑的直径测量装置（230）和由基座（210）支撑的罐夹具（220） 罐夹具（220）布置成相对于直径测量装置（230）以预定的测量高度保持放置在其中的罐（10）。

公开(公告)号：US20080011291A1

公开(公告)日：2008-01-17

申请号：US11664739

申请日：2005-10-06

申请人： Ian Fletcher ,  Stephen Metcalf ,  Darren Hodson

发明人： Ian Fletcher ,  Stephen Metcalf ,  Darren Hodson

IPC分类号： A61M11/00

CPC分类号： B65D83/38 ,  B65D83/52

摘要： Inhaler valve (30) comprising a gathering ring (70) comprised of a non-elastomeric polymer-material, wherein at least one annular section (110, 140, 160, 180) of the gathering ring (70) is formed to be deformable in the radial direction in order to absorb over compression of the ring outer periphery when crimping the valve (30) onto a container (20). There is also provided an inhaler container (10) with such an inhaler valve.

摘要翻译： 吸入阀（30）包括由非弹性聚合物材料组成的聚集环（70），其中聚集环（70）的至少一个环形部分（110,140,​​160,180）形成为可变形 径向方向，以便在将阀（30）压接到容器（20）上时吸收环外周的过度压缩。 还提供了具有这种吸入器阀的吸入器容器（10）。

公开(公告)号：US06820463B2

公开(公告)日：2004-11-23

申请号：US10476900

申请日：2003-11-04

申请人： Ian Fletcher ,  Stephen Metcalf

发明人： Ian Fletcher ,  Stephen Metcalf

IPC分类号： G01M302

CPC分类号： G01N7/14 ,  A61M15/009 ,  A61M2205/3331 ,  A61M2209/02 ,  B65D83/38

摘要： The invention relates to testing apparatus (1) for testing a container (2) of a suspension of a substance (3). The substance may in particular, but not solely, comprise a pharmaceutical substance. The substance (3) is suspended in a propellant (4), which is under pressure. The container (2) itself comprises a body (5), which defines a chamber and has a valve stem (6), which extends from a head of the body. A metering chamber is selectively communicable, by means of the valve stem, with the atmosphere and the chamber (7). The valve stem providing via a L-shaped conduit, which extends between the free end and the side wall thereof the outlet of the container (2) through which metered doses of the substance are released from the container (2). The testing apparatus (1) includes a gallery (8) for communicating, in use, in a fluid-tight manner with the said valve stem and actuating means, in use, actuating the valve stem so as to discharge a metered dose of substance and/or propellant into the gallery, repeatedly if necessary, until the pressure within the gallery is substantially equalised with the pressure within the container (2). The testing apparatus further includes pressure-measuring means (9) in communication with said gallery to provide a measurement of the pressure therein and hence the pressure within the container (2).

摘要翻译： 本发明涉及一种用于测试物质（3）的悬浮液的容器（2）的测试装置（1）。 该物质可以特别但不仅仅包含药物物质。 物质（3）悬浮在压力下的推进剂（4）中。 容器（2）本身包括主体（5），该主体限定了一个室，并具有从主体的头部延伸的阀杆（6）。 计量室通过阀杆与大气和室（7）可选地可连接。 所述阀杆通过L形导管提供，所述L形导管在其自由端和侧壁之间延伸出容器（2）的出口，通过该容器（2）的计量剂量从容器（2）释放。 测试装置（1）包括用于在使用中以流体密封的方式与所述阀杆和致动装置在使用中在致动阀杆以便排出计量剂量的物质的通道的通道（8） /或推进剂反复进入画廊，如有必要，直到画廊内的压力与容器（2）内的压力基本相等。 测试装置还包括与所述外壳连通的压力测量装置（9），以提供其中的压力的​​测量值，并因此测量容器（2）内的压力。

公开(公告)号：US20060228570A1

公开(公告)日：2006-10-12

申请号：US10554967

申请日：2004-04-26

申请人： Stephen Burns ,  Ian Fletcher ,  Stephen Metcalf

发明人： Stephen Burns ,  Ian Fletcher ,  Stephen Metcalf

IPC分类号： B32B15/08

CPC分类号： A61K9/008 ,  B01J19/02 ,  B01J2219/0245 ,  Y10T428/31692

摘要： The invention relates to the use of a coated manufacturing vessel in pharmaceutical production. A polymer coating (ECTFE, PVDF, PFA) avoids the adhesion or sticking of compounds within the vessel.

摘要翻译： 本发明涉及在药物生产中使用涂覆的制造容器。 聚合物涂层（ECTFE，PVDF，PFA）避免了化合物在容器内的粘附或粘附。

公开(公告)号：US06786023B2

公开(公告)日：2004-09-07

申请号：US10376270

申请日：2003-03-03

申请人： John Brennan ,  Ian Fletcher ,  Stephen Metcalf ,  Yogesh Pancholi ,  David Smith

发明人： John Brennan ,  Ian Fletcher ,  Stephen Metcalf ,  Yogesh Pancholi ,  David Smith

IPC分类号： B65B3100

CPC分类号： B65B31/003

摘要： A filling apparatus for, a filling system for and a method of introducing into a container a suspension or solution of a substance, in particular a pharmaceutical substance, in a propellant under pressure, the filling apparatus comprising: a main body (4) including a passageway (20) having an inlet opening (21) and first and second outlet openings (25, 22), the first outlet opening (25) communicating, in use, with a valve stem (144) extending from a head (141) of a body (139) of a container (138); a fill actuator (7) in communication with the inlet opening (21) of the passageway (20) comprising a filling valve assembly (29) for selectively introducing propellant under pressure containing a substance in a suspension or solution into the passageway (20); an exhaust actuator (10) in communication with the second outlet opening (22) of the passageway (20) comprising an exhaust valve assembly (48) for selectively exhausting propellant under pressure containing substance from the passageway (20) and including at least one exhaust gas conduit (84, 92, 93) having an outlet (86, 94, 95) configured so as, in use, to provide a flow of exhaust gas substantially aligned with a flow of propellant containing substance from the second outlet opening (22) of the passageway (20); and a container-engaging body (16) for receiving, in use, the head (141) of the body (139) of the container (138) which includes the valve stem (144).

摘要翻译： 一种用于填充装置的灌装装置，以及一种在压力下向推进剂中引入物质特别是药物的悬浮液或溶液的容器的方法，所述填充装置包括：主体（4），包括： 通道（20）具有入口开口（21）和第一和第二出口开口（25,22），第一出口开口（25）在使用中与从其头部（141）延伸的阀杆（144）连通， 容器（138）的主体（139）; 与所述通道（20）的入口（21）连通的填充致动器（7）包括用于在压力下将推进剂选择性地引入悬浮液或溶液的通道（20）中的填充阀组件（29）; 与所述通道（20）的第二出口（22）连通的排气致动器（10）包括排气阀组件（48），用于在压力下选择性地排出推进剂，所述推进剂含有来自所述通道（20）的物质，并且包括至少一个排气 具有出口（86,94,95）的气体导管（84,92,93）构造成在使用中提供与来自第二出口开口（22）的含有推进剂的物质的流体基本对齐的废气流， 的通道（20）; 以及用于在使用中接收包括所述阀杆（144）的所述容器（138）的主体（139）的头部（141）的容器接合体（16）。

公开(公告)号：US07245824B2

公开(公告)日：2007-07-17

申请号：US10220954

申请日：2001-03-07

申请人： Ian Fletcher

发明人： Ian Fletcher

IPC分类号： H04N5/91 ,  H04N7/00

CPC分类号： G06F17/30799

摘要： An image indexing system comprising a video frame store, an averager which provides a first signal indicative of the average brightness level of each frame stored, an image splitter and averager which divides each frame into contiguous blocks of pixels, and provides for each block, a second signal indicative of its average brightness level, a comparator which compares each of the second signals with the first signal so as to produce in respect of each block a binary signal indicative of whether or not its brightness level, as indicated by the first signal, is greater or less than the average brightness level for the frame as indicated by the first signal, thereby to produce for each frame, an index signal comprising one binary bit for each block which serves to identify each frame for indexing purposes.

摘要翻译： 一种图像索引系统，包括视频帧存储器，平均器，其提供指示存储的每个帧的平均亮度级别的第一信号;图像分离器和平均器，其将每个帧划分成连续的像素块，并且为每个块提供一个 指示其平均亮度级的第二信号，比较器，其将每个第二信号与第一信号进行比较，以便针对每个块产生指示其亮度级别（如第一信号所指示）是否为二进制信号的二进制信号， 大于或小于由第一信号指示的帧的平均亮度级，从而为每个帧产生索引信号，该索引信号包括用于每个块的一个二进制位，用于识别每个帧用于索引目的。

公开(公告)号：USD1017502S1

公开(公告)日：2024-03-12

申请号：US29813421

申请日：2021-10-28

申请人： Ian Fletcher

设计人： Ian Fletcher

摘要： FIG. 1 is a front perspective view of a wheel cover;
FIG. 2 is a rear perspective view of the wheel cover;
FIG. 3 is a front upper right perspective exploded view of the wheel cover;
FIG. 4 is a front left perspective view of a rear component of the wheel cover;
FIG. 5 is a front elevational view of the rear component of the wheel cover;
FIG. 6 is a rear upper right perspective exploded view of the wheel cover.
FIG. 7 is a rear upper right perspective view of a front component of the wheel cover;
FIG. 8 is a rear elevational view of the front component of the wheel cover;
FIG. 9 is a front elevational view of the wheel cover;
FIG. 10 is a rear elevational view of the wheel cover;
FIG. 11 is a left side elevational view of the wheel cover;
FIG. 12 is a right side elevational view of the wheel cover;
FIG. 13 is a top plan view of the wheel cover; and,
FIG. 14 is a bottom plan view of the wheel cover.

公开(公告)号：US20090106996A1

公开(公告)日：2009-04-30

申请号：US12258003

申请日：2008-10-24

申请人： Ian Fletcher

发明人： Ian Fletcher

IPC分类号： G01D21/00

CPC分类号： G01B5/25

摘要： In one implementation, an inhaler valve alignment measurement device includes an extended pointer arranged in alignment with a first canister member, e.g. a valve stem or a valve base, and an extended reference member arranged in alignment with a second canister member, e.g. a valve base or a canister wall. The extended reference member includes a visual alignment indicator indicative of the relative alignment of the extended pointer and the extended reference member at a predetermined distance from the canister members.

摘要翻译： 在一个实施方案中，吸入器阀对准测量装置包括布置成与第一罐构件对准的延伸指示器，例如， 阀杆或阀座，以及与第二罐构件对准布置的延伸的基准构件，例如。 阀座或罐壁。 扩展的参考构件包括指示扩展指针和扩展的参考构件在距离罐构件预定距离处的相对对准的视觉对准指示器。

公开(公告)号：US20100276459A1

公开(公告)日：2010-11-04

申请号：US12666763

申请日：2008-06-27

申请人： Christophe Marie ,  Ian Fletcher

发明人： Christophe Marie ,  Ian Fletcher

IPC分类号： B65D83/00

CPC分类号： B65D83/36 ,  B65D83/38 ,  B65D83/54

摘要： A ring (10) for disposing around a valve body (21) of an aerosol dispenser valve (20) that is mounted by means of a fastener element (50), such as a crimpable capsule, on a reservoir (1) containing fluid to be dispensed, said ring (10) comprising at least an outer portion (15) and an inner portion (11, 11′) that co-operates with said valve body (21), said ring (10) being made as a single piece that is substantially rigid, said outer portion (15) being adapted to co-operate in leaktight manner, by deformation of its material, with a portion of the reservoir (1) while the fastener element (50) is being assembled on the reservoir (1).

摘要翻译： 一种用于在气溶胶分配阀（20）的阀体（21）周围设置的环（10），其通过诸如可卷缩胶囊的紧固元件（50）安装在储存器（1）上，所述容器（1）包含流体 所述环（10）至少包括外部部分（15）和与所述阀体（21）配合的内部部分（11,11'），所述环（10）制成单件 所述外部部分（15）适于通过其材料的变形与所述储存器（1）的一部分相配合，同时所述紧固元件（50）组装在所述储存器（1）上， 1）。

公开(公告)号：US20060155124A1

公开(公告)日：2006-07-13

申请号：US10534315

申请日：2003-11-11

申请人： Goetz Scheffler ,  Peter Rohringer ,  Ian Fletcher

发明人： Goetz Scheffler ,  Peter Rohringer ,  Ian Fletcher

IPC分类号： C07D487/00

CPC分类号： D21H21/30

摘要： The present invention provides novel bis-triazinylaminostilbene amphoteric fluorescent whitening agents, comprising both individual components and mixtures thereof, a process for their preparation, intermediates useful for their prepartion and use of the fluorescent whitening agents for the fluorescents whitening of paper.

摘要翻译： 本发明提供了新颖的双 - 三嗪基氨基芪两性荧光增白剂，其包括单独组分及其混合物，其制备方法，可用于其制备的中间体和使用荧光增白剂用于荧光增白纸。