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    Method and apparatus for noninvasive glucose concentration estimation through near-infrared spectroscopy
    2.
    发明申请
    Method and apparatus for noninvasive glucose concentration estimation through near-infrared spectroscopy 审中-公开
    通过近红外光谱法进行非侵入性葡萄糖浓度估算的方法和装置

    公开(公告)号：US20050107676A1

    公开(公告)日：2005-05-19

    申请号：US10971447

    申请日：2004-10-21

    申请人： George Acosta ,  James Henderson ,  N. Abul-Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

    发明人： George Acosta ,  James Henderson ,  N. Abul-Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B2560/0223 ,  A61B2560/0233

    摘要： A near-infrared spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and is used to collect spectral measurements of a tissue sample. The spectral readings are used to estimate a biological parameter in the sampled tissue noninvasively, such as glucose concentration. The preferred apparatus is a near-infrared analyzer that includes a base module and a sample module connected together with a communication bundle. The base module contains the bulk of the analyzer, such as a spectrograph and a central processing unit with an algorithm used for converting the optical signal into a glucose concentration. The sample module is typically in a smaller module that interfaces to a tissue sample. The sample module is preferably handheld and provides minimal sampling distortion due to heat or pressure.

    摘要翻译： 基于近红外光谱仪的分析仪连续地或半连续地连接到人类受试者，并用于收集组织样本的光谱测量。 光谱读数用于非侵入性地估计采样组织中的生物学参数，如葡萄糖浓度。 优选的装置是近红外分析器，其包括与通信束连接在一起的基本模块和样本模块。 基本模块包含分析仪的大部分，例如光谱仪和具有用于将光信号转换为葡萄糖浓度的算法的中央处理单元。 样品模块通常在与组织样品接口的较小模块中。 样品模块优选是手持式的，并且由于热或压力而提供最小的采样失真。

    APPARATUS AND METHOD FOR EASING USE OF A SPECTROPHOTOMETRIC BASED NONINVASIVE ANALYZER
    6.
    发明申请
    APPARATUS AND METHOD FOR EASING USE OF A SPECTROPHOTOMETRIC BASED NONINVASIVE ANALYZER 有权
    用于分光光度计的非分析分析仪的设备和方法

    公开(公告)号：US20070293743A1

    公开(公告)日：2007-12-20

    申请号：US11848139

    申请日：2007-08-30

    申请人： Stephen Monfre ,  George Acosta ,  Thomas Blank ,  Kevin Hazen

    发明人： Stephen Monfre ,  George Acosta ,  Thomas Blank ,  Kevin Hazen

    IPC分类号： A61B5/00

    CPC分类号： A61B5/6841 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/359 ,  G01N21/474

    摘要： A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.

    摘要翻译： 公开了一种具有改进的水合诱导塞的放置引导装置，其用于将非侵入性分析器耦合到取样部位以确定人体中的分析物。 水合诱导塞包括至少一种可用作偶联剂的含氟聚合物。 引导装置还可以包括自动化或半自动化耦合流体输送系统。 使用这些耦合剂中的任一种可减轻与相关技术相关的问题，并增强非侵入性分析物测量，例如基于近红外漫反射的非侵入性葡萄糖浓度分析仪。

    Sampling interface system for in-vivo estimation of tissue analyte concentration
    9.
    发明申请
    Sampling interface system for in-vivo estimation of tissue analyte concentration 审中-公开
    用于体内估计组织分析物浓度的采样界面系统

    公开(公告)号：US20050187439A1

    公开(公告)日：2005-08-25

    申请号：US11031103

    申请日：2005-01-06

    申请人： Thomas Blank ,  George Acosta ,  Stephen Monfre ,  Roxanne Abul-Haj ,  Kevin Hazen ,  Sedar Brown ,  Benjamin Richie ,  James Henderson ,  Barry Elliott ,  Josh Hope

    发明人： Thomas Blank ,  George Acosta ,  Stephen Monfre ,  Roxanne Abul-Haj ,  Kevin Hazen ,  Sedar Brown ,  Benjamin Richie ,  James Henderson ,  Barry Elliott ,  Josh Hope

    IPC分类号： A61B5/00 ,  G01N21/35

    CPC分类号： G01N21/359 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2562/146

    摘要： Sampling is controlled to enhance analyte concentration estimation derived from noninvasive sampling. Means of assuring that the same tissue sample volume is repeatably sampled are presented, thus minimizing sampling errors due to mechanical tissue distortion, specular reflectance, and probe placement. In a first embodiment of the invention, sampling is controlled using automated delivery of a coupling fluid to a region between a tip of a sample probe and a tissue measurement site in a manner requiring minimal user interaction. In a second embodiment of the invention, sampling is controlled by controlling temperature variations, preferably with a coupling fluid, at a region about the tip of a sample probe and a sample site. In a third embodiment, sampling is procedurally controlled via timing and location of coupling fluid delivery to a sample site.

    摘要翻译： 控制采样以增强从无创采样得到的分析物浓度估计。 呈现确保相同组织样本体积被重复采样的方法，从而最小化由于机械组织变形，镜面反射率和探针放置引起的采样误差。 在本发明的第一实施例中，采用自动化方式将耦合流体以需要最少用户相互作用的方式自动传送到样品探针的尖端和组织测量部位之间的区域进行控制。 在本发明的第二实施例中，通过在围绕样品探针的尖端的区域和样品位置处控制温度变化来控制采样，优选地通过耦合流体进行控制。 在第三实施例中，通过将流体输送到样品位置的定时和位置程序地控制采样。