公开(公告)号：US20090264858A1

公开(公告)日：2009-10-22

申请号：US12107527

申请日：2008-04-22

申请人： Stephen Nash ,  Patricia O'Beirne ,  David Johnson ,  Stephen Gormley ,  Grace Kelly

发明人： Stephen Nash ,  Patricia O'Beirne ,  David Johnson ,  Stephen Gormley ,  Grace Kelly

IPC分类号： A61M31/00 ,  A61M25/00

CPC分类号： A61M25/0069 ,  A61M2025/0057 ,  A61M2025/1093

摘要： A catheter is disclosed that has a detachable tip for delivery of a therapeutic substance to a chronic total occlusion (CTO) within a body vessel. The tip is made from a biodegradable material and includes an active agent dispersed therethrough. The detachable tip pierces into the calcified lesion, detaches from the catheter, and remains embedded within the lesion as the tip degrades, thereby releasing the active agent. The active agent is a therapeutic substance effective to treat of a CTO. The active agent may be a drug, an enzyme, bacteria, or a parasite that degrades or softens the calcified lesion.

摘要翻译： 公开了一种导管，其具有用于将治疗物质递送至体内容器内的慢性完全闭塞（CTO）的可拆卸末端。 尖端由可生物降解的材料制成并且包括分散在其中的活性剂。 可拆卸的尖端刺入钙化的病变，从导管分离，并且随着尖端降解而保持嵌入损伤内，从而释放活性剂。 活性剂是有效治疗CTO的治疗物质。 活性剂可以是降解或软化钙化病变的药物，酶，细菌或寄生虫。

公开(公告)号：US08016799B2

公开(公告)日：2011-09-13

申请号：US12107527

申请日：2008-04-22

申请人： Stephen Nash ,  Patricia O'Beirne ,  David Johnson ,  Stephen Gormley ,  Grace Kelly

发明人： Stephen Nash ,  Patricia O'Beirne ,  David Johnson ,  Stephen Gormley ,  Grace Kelly

IPC分类号： A61M5/32

CPC分类号： A61M25/0069 ,  A61M2025/0057 ,  A61M2025/1093

摘要： A catheter is disclosed that has a detachable tip for delivery of a therapeutic substance to a chronic total occlusion (CTO) within a body vessel. The tip is made from a biodegradable material and includes an active agent dispersed therethrough. The detachable tip pierces into the calcified lesion, detaches from the catheter, and remains embedded within the lesion as the tip degrades, thereby releasing the active agent. The active agent is a therapeutic substance effective to treat of a CTO. The active agent may be a drug, an enzyme, bacteria, or a parasite that degrades or softens the calcified lesion.

摘要翻译： 公开了一种导管，其具有用于将治疗物质递送至体内容器内的慢性完全闭塞（CTO）的可拆卸末端。 尖端由可生物降解的材料制成并且包括分散在其中的活性剂。 可拆卸的尖端刺入钙化的病变，从导管分离，并且随着尖端降解而保持嵌入损伤内，从而释放活性剂。 活性剂是有效治疗CTO的治疗物质。 活性剂可以是降解或软化钙化病变的药物，酶，细菌或寄生虫。

公开(公告)号：US08873900B2

公开(公告)日：2014-10-28

申请号：US13091319

申请日：2011-04-21

申请人： Patricia O'Beirne ,  Aram Jamous ,  John Kelly

发明人： Patricia O'Beirne ,  Aram Jamous ,  John Kelly

IPC分类号： G02B6/00 ,  A61M29/00 ,  A61M25/10 ,  G01L1/24

CPC分类号： A61M25/104 ,  A61M2205/3306 ,  G01L1/246

摘要： An apparatus and method for determining an expanded diameter of a catheter balloon. An optical sensor includes an elongated optical fiber with at least one diffraction grating formed in a core of a distal portion thereof. The fiber distal portion is coupled to the inflatable balloon. Broadband light is transmitted to the diffraction grating by an optical interrogator. A portion of the light is reflected from the diffraction grating and is received by a wavelength detector. The wavelength of the reflected portion of light is dependent on the strain applied to the diffraction grating. The wavelength detector determines the strain in the balloon and correlates the strain to the diameter of the balloon.

摘要翻译： 一种用于确定导管球囊的扩大直径的装置和方法。 光学传感器包括细长光纤，其中至少一个衍射光栅形成在其远端部分的芯中。 纤维远端部分连接到可充气球囊。 宽光束通过光学询问器传输到衍射光栅。 一部分光从衍射光栅反射并被波长检测器接收。 光的反射部分的波长取决于施加到衍射光栅的应变。 波长检测器确定球囊中的应变并将应变与球囊的直径相关联。

公开(公告)号：US08795352B2

公开(公告)日：2014-08-05

申请号：US12326525

申请日：2008-12-02

申请人： Patricia O'Beirne ,  Nasser Rafiee

发明人： Patricia O'Beirne ,  Nasser Rafiee

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61B17/0487 ,  A61B2017/00243 ,  A61B2017/00783 ,  A61B2017/0409 ,  A61B2017/0441 ,  A61B2017/0496 ,  A61F2/2427 ,  A61F2/2442 ,  A61F2/2466

摘要： A system for treating mitral valve regurgitation includes a tensioning device having a plurality of helical anchors and a tensioning filament. One embodiment of the invention includes a method for attaching a tensioning device to the annulus of a mitral valve in a trans-leaflet configuration, and applying a tension force to the tension filament in order to exert force vectors on the annulus, thereby reshaping the mitral valve annulus so that the coaption of the anterior and posterior leaflets of the mitral is improved during ventricular contraction.

摘要翻译： 用于治疗二尖瓣反流的系统包括具有多个螺旋锚和张紧丝的张紧装置。 本发明的一个实施例包括一种用于将张紧装置附接到跨瓣构造的二尖瓣环上的方法，并且向张力丝施加张力以在环上施加力矢量，从而重新形成二尖瓣 瓣膜环，使得在心室收缩期间二尖瓣的前叶和后叶的结构得到改善。

公开(公告)号：US20120271339A1

公开(公告)日：2012-10-25

申请号：US13091319

申请日：2011-04-21

申请人： Patricia O'Beirne ,  Aram Jamous ,  John Kelly

发明人： Patricia O'Beirne ,  Aram Jamous ,  John Kelly

IPC分类号： A61M29/02

CPC分类号： A61M25/104 ,  A61M2205/3306 ,  G01L1/246

摘要： An apparatus and method for determining an expanded diameter of a catheter balloon. An optical sensor includes an elongated optical fiber with at least one diffraction grating formed in a core of a distal portion thereof. The fiber distal portion is coupled to the inflatable balloon. Broadband light is transmitted to the diffraction grating by an optical interrogator. A portion of the light is reflected from the diffraction grating and is received by a wavelength detector. The wavelength of the reflected portion of light is dependent on the strain applied to the diffraction grating. The wavelength detector determines the strain in the balloon and correlates the strain to the diameter of the balloon.

摘要翻译： 一种用于确定导管球囊的扩大直径的装置和方法。 光学传感器包括细长光纤，其中至少一个衍射光栅形成在其远端部分的芯中。 纤维远端部分连接到可充气球囊。 宽光束通过光学询问器传输到衍射光栅。 一部分光从衍射光栅反射并被波长检测器接收。 光的反射部分的波长取决于施加到衍射光栅的应变。 波长检测器确定球囊中的应变并将应变与球囊的直径相关联。

公开(公告)号：US20090259304A1

公开(公告)日：2009-10-15

申请号：US12326525

申请日：2008-12-02

申请人： Patricia O'Beirne ,  Nasser Rafiee

发明人： Patricia O'Beirne ,  Nasser Rafiee

IPC分类号： A61F2/24 ,  A61B17/04

CPC分类号： A61F2/2445 ,  A61B17/0487 ,  A61B2017/00243 ,  A61B2017/00783 ,  A61B2017/0409 ,  A61B2017/0441 ,  A61B2017/0496 ,  A61F2/2427 ,  A61F2/2442 ,  A61F2/2466

摘要： A system for treating mitral valve regurgitation includes a tensioning device having a plurality of helical anchors and a tensioning filament. One embodiment of the invention includes a method for attaching a tensioning device to the annulus of a mitral valve in a trans-leaflet configuration, and applying a tension force to the tension filament in order to exert force vectors on the annulus, thereby reshaping the mitral valve annulus so that the coaption of the anterior and posterior leaflets of the mitral is improved during ventricular contraction.

摘要翻译： 用于治疗二尖瓣反流的系统包括具有多个螺旋锚和张紧丝的张紧装置。 本发明的一个实施例包括一种用于将张紧装置附接到跨瓣构造的二尖瓣环上的方法，并且向张力丝施加张力以在环上施加力矢量，从而重新形成二尖瓣 瓣膜环，使得在心室收缩期间二尖瓣的前叶和后叶的结构得到改善。