Integrated footwear construction and related method of manufacture
    1.
    发明申请
    Integrated footwear construction and related method of manufacture 有权
    综合鞋类建设及相关制造方法

    公开(公告)号:US20050022429A1

    公开(公告)日:2005-02-03

    申请号:US10848670

    申请日:2004-05-19

    摘要: An integrated article of footwear including a waterproofing membrane direct attached to an upper of the footwear. An outsole is further secured to the membrane and/or the upper. In one embodiment, the membrane includes a visible aesthetic bead in the footwear forefoot region, but not the heel region. The membrane may be of greater thickness in the forefoot region to provide added rigidity. A heel cradle is positioned in the footwear heel region between the upper and the outsole. The footwear provides the durability of a direct attach construction in the forefoot and the comfort and cushion of an athletic construction in the heel of the shoe. A method for constructing the footwear includes direct attaching the membrane to an upper of the shoe. Optionally, a heel cradle is disposed in the heel region of the shoe, and the outsole is secured to the heel cradle and/or upper there.

    摘要翻译: 包括直接连接到鞋的鞋面的防水膜的整体鞋类物品。 外底进一步固定在膜和/或鞋面上。 在一个实施例中,膜包括鞋类前脚掌区域中的可见的美观珠,但不包括鞋跟区域。 在前足区域中膜可以具有更大的厚度以提供附加的刚性。 脚跟支架位于鞋帮和鞋底之间的鞋跟跟部区域中。 该鞋类提供了前脚掌中的直接附接结构的耐久性以及鞋跟中运动结构的舒适性和缓冲性。 用于构造鞋类的方法包括将膜直接附接到鞋的鞋面。 任选地,脚跟支架设置在鞋的跟部区域中,并且外底固定到脚跟支架和/或上方。

    INTEGRATED FOOTWEAR CONSTRUCTION AND RELATED METHOD OF MANUFACTURE
    2.
    发明申请
    INTEGRATED FOOTWEAR CONSTRUCTION AND RELATED METHOD OF MANUFACTURE 审中-公开
    一体化鞋类结构及相关制造方法

    公开(公告)号:US20060265908A1

    公开(公告)日:2006-11-30

    申请号:US11426181

    申请日:2006-06-23

    IPC分类号: A43B13/20

    摘要: An integrated article of footwear including a waterproofing membrane direct attached to an upper of the footwear. An outsole is further secured to the membrane and/or the upper. In one embodiment, the membrane includes a visible aesthetic bead in the footwear forefoot region, but not the heel region. The membrane may be of greater thickness in the forefoot region to provide added rigidity. A heel cradle is positioned in the footwear heel region between the upper and the outsole. The footwear provides the durability of a direct attach construction in the forefoot and the comfort and cushion of an athletic construction in the heel of the shoe. A method for constructing the footwear includes direct attaching the membrane to an upper of the shoe. Optionally, a heel cradle is disposed in the heel region of the shoe, and the outsole is secured to the heel cradle and/or upper there.

    摘要翻译: 包括直接连接到鞋的鞋面的防水膜的整体鞋类物品。 外底进一步固定在膜和/或鞋面上。 在一个实施例中,膜包括鞋类前脚掌区域中的可见的美观珠,但不包括鞋跟区域。 在前足区域中膜可以具有更大的厚度以提供附加的刚性。 脚跟支架位于鞋帮和鞋底之间的鞋跟跟部区域中。 该鞋类提供了前脚掌中的直接附接结构的耐久性以及鞋跟中运动结构的舒适性和缓冲性。 用于构造鞋类的方法包括将膜直接附接到鞋的鞋面。 任选地,脚跟支架设置在鞋的跟部区域中,并且外底固定到脚跟支架和/或上方。

    Methods of inducing ovulation
    7.
    发明授权
    Methods of inducing ovulation 失效
    诱导排卵的方法

    公开(公告)号:US07078236B2

    公开(公告)日:2006-07-18

    申请号:US11169183

    申请日:2005-06-28

    IPC分类号: A61K38/24 C12N15/15

    摘要: The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.

    摘要翻译: 本发明涉及在雌性宿主中诱导排卵的方法,包括向雌性宿主施用非多肽环状腺苷一磷酸(cAMP)水平调节剂。 另一方面,本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂,特别是磷酸二酯酶4同种型的抑制剂。