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公开(公告)号:US20140045704A1
公开(公告)日:2014-02-13
申请号:US13886068
申请日:2013-05-02
申请人: Stevan Bogdan Jovanovich , luliu I. Balga , Allen R. Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
发明人: Stevan Bogdan Jovanovich , luliu I. Balga , Allen R. Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
CPC分类号: C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2300/0896 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B82Y30/00 , F16K99/0001
摘要: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.
摘要翻译: 本发明公开了可编程微流体电路的集成,以实现处理生化和化学反应的实际应用并整合这些反应。 在一些实施方案中,组合用于生化反应或化学工作流程的工作流程。 公开了诸如具有Y阀和流过阀的可编程微流体电路的微型阀。 在一些实施方案中,本发明的微型阀用于混合流体,其可以是整合过程的一部分。 这些过程包括将样品和移动反应混合到用于模块化微流体的边缘或储存器,使用捕获区域以及将其注入分离装置中的分析装置中。 在一些实施例中,使用星形和嵌套星形设计,或者通过微通道中的通道的横截面积的改变来进行珠捕获。 使用固定温度和通过微型泵将样品移动进一步公开了温度区之间样品的移动。