公开(公告)号：US20240359179A1

公开(公告)日：2024-10-31

申请号：US18537233

申请日：2023-12-12

申请人： HANDYLAB, INC.

发明人： Jeff Williams ,  Kerry Wilson ,  Kalyan Handique

IPC分类号： B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  B01L9/00 ,  B01L9/06 ,  F16K99/00 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

CPC分类号： B01L3/502761 ,  B01L3/0275 ,  B01L3/5027 ,  B01L3/52 ,  B01L7/52 ,  B01L9/06 ,  B01L9/527 ,  F16K99/0001 ,  F16K99/003 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0061 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/045 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0442 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0611 ,  B01L2400/0677 ,  B01L2400/0683 ,  F16K2099/0084 ,  G01N2035/00881 ,  G01N35/026 ,  G01N2035/0425 ,  G01N2035/0436

摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

公开(公告)号：US12083521B2

公开(公告)日：2024-09-10

申请号：US16626647

申请日：2018-07-02

申请人： BLINK AG

发明人： Torsten Schulz ,  Eugen Ermantraut ,  Katrin Steinmetzer ,  Alrik Wolff

IPC分类号： B01F35/513 ,  B01F23/411 ,  B01F31/20 ,  B01L3/00 ,  B01L7/00 ,  B01L99/00 ,  C12M1/00 ,  C12M1/34 ,  G01N15/00 ,  G01N15/1433 ,  G01N15/14

CPC分类号： B01L7/52 ,  B01F23/4111 ,  B01F31/20 ,  B01F35/513 ,  B01L3/502776 ,  B01L3/505 ,  C12M41/14 ,  G01N15/1433 ,  B01L2200/0636 ,  B01L2200/0684 ,  B01L2300/042 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/1822 ,  B01L2400/0409 ,  B01L2400/0457 ,  B01L2400/0481 ,  B01L2400/049 ,  B01L2400/0655 ,  G01N2015/1493

摘要： The present invention relates to a sample cartridge for incubating and/or analyzing a dispersion of particles, cells or droplets and/or for performing biochemical reactions with or in such dispersion. The present invention furthermore relates to a device for incubating a dispersion of particles, cells or droplets and/or for performing a biochemical reaction therewith. Moreover, the present invention also relates to the use of a sample cartridge or of a device for generating and/or processing a dispersion of particles, cells or droplets. Moreover, the present invention relates to a method of processing a dispersion of particles, cells or droplets. Furthermore, the present invention relates to a method of generating a dispersion of droplets and to a method of generating a dispersion of solid or semi-solid particles.

公开(公告)号：US20240269680A1

公开(公告)日：2024-08-15

申请号：US18627417

申请日：2024-04-04

申请人： Biofire Defense, LLC

发明人： Kirk Max Ririe ,  David E. Jones ,  Christopher Paul Pasko ,  Anson Cole Chamberlain ,  Derek David ,  Aaron Wernerehl ,  Jonathan Allen Bruns

IPC分类号： B01L7/00 ,  B01L3/00 ,  C12Q1/686

CPC分类号： B01L7/525 ,  B01L3/50273 ,  C12Q1/686 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2300/1816 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0481

摘要： Instruments, methods, and kits are disclosed for performing fast thermocycling.

公开(公告)号：US12053780B2

公开(公告)日：2024-08-06

申请号：US17470615

申请日：2021-09-09

申请人： CUE HEALTH INC.

发明人： Ayub Khattak ,  Clinton Sever ,  Paul Nelson ,  Ryan Cooper ,  Thomas Congdon ,  Justin Demartino ,  Raphael Shapiro ,  Mark Duncan

IPC分类号： B01L3/00 ,  A61B10/00 ,  A61B10/02 ,  B65D83/00 ,  B65D83/04 ,  B65D83/08 ,  G01N27/327 ,  G01N33/543 ,  G01N35/00 ,  G01N35/10 ,  A61B5/157 ,  C12Q1/6825

CPC分类号： B01L3/508 ,  A61B10/0045 ,  A61B10/02 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/5029 ,  B01L3/523 ,  B65D83/005 ,  B65D83/04 ,  B65D83/0817 ,  B65D83/0858 ,  G01N27/3273 ,  G01N33/54366 ,  G01N35/0098 ,  G01N35/10 ,  A61B5/157 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/047 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  C12Q1/6825

摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US12029398B2

公开(公告)日：2024-07-09

申请号：US17575196

申请日：2022-01-13

申请人： Zhejiang Orient Gene Biotech Co., Ltd ,  Healgen Scientific Limited

发明人： Siyu Lei ,  Jianqiu Fang ,  Lili Shen

IPC分类号： A61B10/00 ,  A61B5/15 ,  B01L3/00

CPC分类号： A61B10/0051 ,  A61B10/0096 ,  B01L3/502 ,  A61B5/150358 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0481

摘要： The present invention discloses an apparatus for detecting analyte in a liquid sample, comprising a cup body; a first receiving area for receiving a liquid sample; a flow-guiding channel through which a sample can be added or collected; the flow-guiding channel is in communication with the first receiving area, the bottom surface of the flow-guiding channel is a slope; wherein, the first receiving area and the flow-guiding channel are disposed in the cup body; the apparatus further comprises a secondary sampling port; the flow-guiding channel is a groove, in which is provided with a second receiving area; and the second receiving area includes a corner area for collecting samples for secondary sampling. The present invention further provides a method of using the apparatus for detecting an analyte in a liquid sample. The apparatus of the present invention can be used for detecting the presence or amount of an analyte in a liquid sample. When a liquid sample has extremely poor fluidity and/or the sample size is very small, the apparatus is still capable of detecting liquid samples, to facilitate operators to draw liquid samples for second confirmatory detection.

公开(公告)号：US12023157B2

公开(公告)日：2024-07-02

申请号：US16891394

申请日：2020-06-03

申请人： MANN+HUMMEL GmbH

发明人： Dagmar Winkler ,  Heike Rupp ,  Steffen Schuetz ,  Dietmar Talmon-Gros ,  Michael Fasold ,  Alfons-Alois Schwinghammer ,  Frank Bartel ,  Sascha Bauer ,  Patrick Nytz

IPC分类号： A61B5/15 ,  A61B5/153 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  B01D39/20 ,  B01D63/02 ,  B01D65/00 ,  B01D67/00 ,  B01L3/00 ,  G01N1/40 ,  G01N33/49

CPC分类号： A61B5/150755 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150251 ,  A61M1/34 ,  A61M1/3496 ,  A61M1/36 ,  A61M1/3633 ,  B01D63/0233 ,  B01D63/028 ,  B01D63/031 ,  B01D65/00 ,  B01D67/0088 ,  G01N1/4005 ,  G01N33/491 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/153 ,  A61M1/0281 ,  A61M2205/3331 ,  B01D39/2068 ,  B01D2311/02 ,  B01D2313/10 ,  B01D2313/12 ,  B01D2313/24 ,  B01D2313/901 ,  B01D2323/04 ,  B01D2323/20 ,  B01L3/502 ,  B01L2300/0681 ,  B01L2400/0478 ,  B01L2400/0481 ,  G01N2001/4016 ,  G01N2201/0221 ,  G01N2201/0222 ,  G01N2800/22

摘要： A whole blood filtration device is provided with a filter membrane separating a feeding volume and a clean side of the filter membrane from each other. The feeding volume communicates with a first feeding side opening and with a second feeding side opening. The filter membrane has pores with a pore size that ensures permeability of the filter membrane to blood plasma/serum and that retains blood cells. The first feeding side opening can be coupled to a first blood pump for feeding blood from the first feeding side opening into the feeding volume so that blood plasma/serum permeates the filter membrane and blood cells, retained by the filter membrane, exit from the feeding volume through the second feeding side opening.

公开(公告)号：US11998939B2

公开(公告)日：2024-06-04

申请号：US17451310

申请日：2021-10-18

申请人： BioDot, Inc.

发明人： Yehuda Ivri ,  Thomas C. Tisone ,  Eric P. Kuo ,  Shane Gunsalus

IPC分类号： B05B17/06 ,  B01J19/00 ,  B01L3/02

CPC分类号： B05B17/0669 ,  B01J19/0046 ,  B01L3/0268 ,  B05B17/0684 ,  B01J2219/00367 ,  B01J2219/00378 ,  B01J2219/00722 ,  B01L2300/0838 ,  B01L2300/123 ,  B01L2300/165 ,  B01L2400/0481

摘要： A dispenser and methods for transferring liquids are disclosed. The dispenser may include a capillary tube with tip having an aperture, a piezoelectric actuator coupled to the capillary tube at a location. Actuation of the piezoelectric actuator causes a pressure wave to propagate along the capillary tube toward the tip such that radial motion at the location is transmitted as distally extending axial motion of the tip, thereby causing a droplet of a predetermined volume to be ejected from the aperture. In some embodiments, the capillary tube has a modulus of elasticity in a range which dampens acoustical noise from the actuation and provides single drop stability over a range of drop sizes.

公开(公告)号：US11969731B2

公开(公告)日：2024-04-30

申请号：US17103354

申请日：2020-11-24

申请人： BIOFIRE DEFENSE, LLC

发明人： Kirk Max Ririe ,  David E. Jones ,  Christopher Paul Pasko ,  Anson Cole Chamberlain ,  Derek David ,  Aaron Wernerehl ,  Jonathan Allen Bruns

IPC分类号： B01L7/00 ,  B01L3/00 ,  C12Q1/686

CPC分类号： B01L7/525 ,  B01L3/50273 ,  C12Q1/686 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2300/1816 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0481 ,  C12Q1/686 ,  C12Q2527/101 ,  C12Q2537/143 ,  C12Q2537/149 ,  C12Q2561/113 ,  C12Q2563/107 ,  C12Q2563/143

摘要： Instruments, methods, and kits are disclosed for performing fast thermocycling.

公开(公告)号：US20240123444A1

公开(公告)日：2024-04-18

申请号：US18395585

申请日：2023-12-24

申请人： Leslie Don Roberts

发明人： Leslie Don Roberts

IPC分类号： B01L3/00 ,  G01N35/00 ,  G01N35/10

CPC分类号： B01L3/502715 ,  B01L3/502 ,  G01N35/0092 ,  G01N35/10 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0683 ,  B01L2400/082 ,  G01N35/00 ,  G01N2035/00326 ,  G01N2035/0094 ,  G01N35/1079

摘要： A modular system for constructing a variety of self-contained analytical cartridges enabled to perform a number of symmetrical or asymmetrical tests on a single sample source within a single device. Said cartridges are embodied as a readily reversible assemblage of two or more modules that are, in turn, operable to perform one or more tasks of an analytical test as discrete articles-of-manufacture.

公开(公告)号：US20240116682A1

公开(公告)日：2024-04-11

申请号：US18278111

申请日：2022-03-21

申请人： SILGAN DISPENSING SYSTEMS (WUXI) CO. LTD.

发明人： Zhigang LI

IPC分类号： B65D47/18 ,  A45D34/04 ,  B01L3/02 ,  B65D41/04 ,  G01F11/02

CPC分类号： B65D47/18 ,  A45D34/04 ,  B01L3/0272 ,  B65D41/0492 ,  G01F11/028 ,  A45D2200/055 ,  B01L2300/042 ,  B01L2400/0478 ,  B01L2400/0481

摘要： The present invention relates to a cap assembly configured to be attached to a container, the cap assembly comprising: a top cap which includes a rest position and a pressable position; a piston rod connected to the top cap, the piston rod being connected to a piston at the bottom to actuate the piston to move vertically, the piston rod further comprising an inclined upper guiding surface; a deformable element bearing at the top end against the upper guiding surface of the piston rod so that the deformable element is movable along the upper guiding surface; a support which is vertically movable to move the top cap from the rest position to the pressable position, the support including an inclined lower guiding surface against which the bottom end of the deformable element is supported so that the deformable element is movable along the lower guiding surface; when the top cap is pressed, the piston rod moves downwards and actuates the piston to move downwards to dispense material from a dispensing chamber while forcing the deformable element to deform from an initial state and to move along the upper guiding surface and the lower guiding surface; and when the top cap is released, the deformable element returns to the initial state.