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公开(公告)号：US20160016140A1
公开(公告)日：2016-01-21
申请号：US14804675
申请日：2015-07-21
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译： 本发明提供用于执行综合分析的系统，设备，方法和套件。 综合分析可以包括样品处理，库构建，扩增和测序。 集成分析可以在一个或多个流体连接的模块中进行。 一个或多个模块可以由计算机控制和/或自动化。 可以对组织样品，临床样品或环境样品进行综合分析。 集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。
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公开(公告)号：US20110039303A1
公开(公告)日：2011-02-17
申请号：US12526015
申请日：2008-02-05
申请人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
发明人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2300/0896 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B82Y30/00 , F16K99/0001
摘要： The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.
摘要翻译： 本发明公开了可编程微流体电路的集成，以实现处理生化和化学反应的实际应用并整合这些反应。 在一些实施方案中，组合用于生化反应或化学工作流程的工作流程。 公开了诸如具有Y阀和流过阀的可编程微流体电路的微型阀。 在一些实施方案中，本发明的微型阀用于混合流体，其可以是整合过程的一部分。 这些过程包括将样品和移动反应混合到用于模块化微流体的边缘或储存器，使用捕获区域以及将其注入到分离设备上的分析装置中。 在一些实施例中，使用星形和嵌套星形设计，或者通过微通道中的通道的横截面积的改变来进行珠捕获。 使用固定温度和通过微型泵将样品移动进一步公开了温度区之间样品的移动。
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公开(公告)号：US08557518B2
公开(公告)日：2013-10-15
申请号：US12845650
申请日：2010-07-28
申请人： Stevan Bogdan Jovanovich , Iuliu I. Blaga , Michael Nguyen , William D. Nielsen , Mattias Vangbo
发明人： Stevan Bogdan Jovanovich , Iuliu I. Blaga , Michael Nguyen , William D. Nielsen , Mattias Vangbo
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2300/0896 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B82Y30/00 , F16K99/0001
摘要： The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.
摘要翻译： 本发明公开了可编程微流体电路的集成，以实现处理生化和化学反应的实际应用并整合这些反应。 在一些实施方案中，组合用于生化反应或化学工作流程的工作流程。 公开了诸如具有Y阀和流过阀的可编程微流体电路的微型阀。 在一些实施方案中，本发明的微型阀用于混合流体，其可以是整合过程的一部分。 这些过程包括将样品和移动反应混合到用于模块化微流体的边缘或储存器，使用捕获区域以及将其注入到分离设备上的分析装置中。 在一些实施例中，使用星形和嵌套星形设计，或者通过微通道中的通道的横截面积的改变来进行珠捕获。 使用固定温度和通过微型泵将样品移动进一步公开了温度区之间样品的移动。
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公开(公告)号：US20080054630A1
公开(公告)日：2008-03-06
申请号：US11930215
申请日：2007-10-31
IPC分类号： F16L5/00
CPC分类号： F16K99/0001 , F15C5/00 , F16K99/0013 , F16K2099/0084
摘要： A connector is provided for selectively coupling one or more lines or wires (19′, 19″) to a receiving and/or transporting device (27). The connector comprises at least one line or wire receiving ferrule (7) having a plurality of line and/or wire receiving holes (17′-17″) each capable of receiving one of said one or more lines or wires (19′, 19″), wherein said connector further comprises a body (3) for receiving said ferrule (7) and clamping means (9, 11) for exerting a force on said ferrule (7) in order to simultaneously exert a line or wire clamping force on all said line and/or wire receiving holes (17′-17″). In this way all the fluid lines or wires can be clamped at the same time.
摘要翻译： 提供连接器用于选择性地将一个或多个线或线（19'，19“）耦合到接收和/或传送装置（27）。 连接器包括至少一个线或线接收套圈（7），其具有多个线和/或线接收孔（17'-17“），每个线和/或线接收孔能够接收所述一条或多条线或线（19' 19“），其中所述连接器还包括用于接收所述套圈（7）的主体（3）和用于在所述套圈（7）上施加力的夹紧装置（9,11），以便同时施加线或线夹紧 在所有所述线和/或电线接收孔（17'-17“）上的力。 以这种方式，所有流体管线或电线可以同时夹紧。
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公开(公告)号：US20050012327A1
公开(公告)日：2005-01-20
申请号：US10493011
申请日：2002-10-15
CPC分类号： F16K99/0001 , F15C5/00 , F16K99/0013 , F16K2099/0084
摘要： A connector is provided for selectively coupling one or more lines or wires (19′, 19″) to a receiving and/or transporting device (27). The connector comprises at least one line or wire receiving ferrule (7) having a plurality of line and/or wire receiving holes (17′-17″) each capable of receiving one of said one or more lines or wires (19′, 19″), wherein said connector further comprises a body (3) for receiving said ferrule (7) and clamping means (9, 11) for exerting a force on said ferrule (7) in order to simultaneously exert a line or wire clamping force on all said line and/or wire receiving holes (17′-17″). In this way all the fluid lines or wires can be clamped at the same time.
摘要翻译： 提供连接器用于选择性地将一个或多个线或线（19'，19“）耦合到接收和/或传送装置（27）。 连接器包括至少一个线或线接收套圈（7），其具有多个线和/或线接收孔（17'-17“），每个线和/或线接收孔能够接收所述一条或多条线或线（19' 19“），其中所述连接器还包括用于接收所述套圈（7）的主体（3）和用于在所述套圈（7）上施加力的夹紧装置（9,11），以便同时施加线或线夹紧 在所有所述线和/或电线接收孔（17'-17“）上的力。 以这种方式，所有流体管线或电线可以同时夹紧。
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公开(公告)号：US20130203634A1
公开(公告)日：2013-08-08
申请号：US13202884
申请日：2011-08-20
IPC分类号： C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译： 本发明提供用于执行综合分析的系统，设备，方法和套件。 综合分析可以包括样品处理，库构建，扩增和测序。 集成分析可以在一个或多个流体连接的模块中进行。 一个或多个模块可以由计算机控制和/或自动化。 可以对组织样品，临床样品或环境样品进行综合分析。 集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。
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7.发明申请UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权通用样品制备系统及其在综合分析系统中的应用公开(公告)号：US20110005932A1
公开(公告)日：2011-01-13
申请号：US12795515
申请日：2010-06-07
申请人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
发明人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
IPC分类号： G01N27/447 , H01J5/16 , G01J1/58 , G01N21/64
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
摘要翻译： 本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。 例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。 该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。 在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。 在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。 墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。 该系统适合不超过10英尺3的外壳。 并且可以是封闭的，便携式的和/或电池供电的系统。 该系统可用于在不到4小时内从原始样品进行分析。
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8.发明申请Universal sample preparation system and use in an integrated analysis system 审中-公开通用样品制备系统，用于综合分析系统公开(公告)号：US20090253181A1
公开(公告)日：2009-10-08
申请号：US12321594
申请日：2009-01-21
申请人： Mattias Vangbo , William D. Nielsen , Lullu I. Blaga , Seth Stern , Joanne Horn , Michael Van Nguyen , Stevan B. Jovanovich
发明人： Mattias Vangbo , William D. Nielsen , Lullu I. Blaga , Seth Stern , Joanne Horn , Michael Van Nguyen , Stevan B. Jovanovich
CPC分类号： G01N1/34 , B01D17/06 , B01L3/50273 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/0647 , B01L2200/10 , B01L2300/0819 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , G01N1/40 , G01N27/44791 , G01N35/1095 , G01N2035/00158 , Y10T436/143333 , Y10T436/25375
摘要： The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.
摘要翻译： 本发明提供用于将微芯片连接到墨盒和气动歧管的装置和方法。 墨盒，微芯片和气动歧管可以与下游制备装置（如热调节装置和分离和分析装置）集成。
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公开(公告)号：US20140045704A1
公开(公告)日：2014-02-13
申请号：US13886068
申请日：2013-05-02
申请人： Stevan Bogdan Jovanovich , luliu I. Balga , Allen R. Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
发明人： Stevan Bogdan Jovanovich , luliu I. Balga , Allen R. Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2300/0896 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B82Y30/00 , F16K99/0001
摘要： The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.
摘要翻译： 本发明公开了可编程微流体电路的集成，以实现处理生化和化学反应的实际应用并整合这些反应。 在一些实施方案中，组合用于生化反应或化学工作流程的工作流程。 公开了诸如具有Y阀和流过阀的可编程微流体电路的微型阀。 在一些实施方案中，本发明的微型阀用于混合流体，其可以是整合过程的一部分。 这些过程包括将样品和移动反应混合到用于模块化微流体的边缘或储存器，使用捕获区域以及将其注入分离装置中的分析装置中。 在一些实施例中，使用星形和嵌套星形设计，或者通过微通道中的通道的横截面积的改变来进行珠捕获。 使用固定温度和通过微型泵将样品移动进一步公开了温度区之间样品的移动。
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公开(公告)号：US08394642B2
公开(公告)日：2013-03-12
申请号：US12795515
申请日：2010-06-07
申请人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
发明人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
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