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    Fibronectin type III domain based scaffold compositions, methods and uses
    1.
    发明授权
    Fibronectin type III domain based scaffold compositions, methods and uses 有权
    纤连蛋白III型结构域的支架组合物，方法和用途

    公开(公告)号：US09200059B2

    公开(公告)日：2015-12-01

    申请号：US13595484

    申请日：2012-08-27

    申请人： Steve Jacobs ,  Karyn O'Neil

    发明人： Steve Jacobs ,  Karyn O'Neil

    IPC分类号： C40B50/06 ,  C07K14/78

    CPC分类号： C07K14/78 ,  C40B40/08 ,  C40B50/06

    摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

    摘要翻译： 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

    Fibronectin type III domain based scaffold compositions, methods and uses
    2.
    发明授权
    Fibronectin type III domain based scaffold compositions, methods and uses 有权
    纤连蛋白III型结构域的支架组合物，方法和用途

    公开(公告)号：US08293482B2

    公开(公告)日：2012-10-23

    申请号：US12704824

    申请日：2010-02-12

    申请人： Steven Jacobs ,  Karyn O'Neil

    发明人： Steven Jacobs ,  Karyn O'Neil

    IPC分类号： C07K16/00 ,  G01N33/53

    CPC分类号： C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C40B40/08 ,  C40B50/06

    摘要： A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.

    摘要翻译： 基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。 特别地，已经鉴定了基于共有序列与IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。

    Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses
    7.
    发明申请
    Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses 有权
    纤连蛋白III型域支架组合物，方法和用途

    公开(公告)号：US20130096019A1

    公开(公告)日：2013-04-18

    申请号：US13595484

    申请日：2012-08-27

    申请人： Steven Jacobs ,  Karyn O'Neil

    发明人： Steven Jacobs ,  Karyn O'Neil

    IPC分类号： C07K14/78

    CPC分类号： C07K14/78 ,  C40B40/08 ,  C40B50/06

    摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

    摘要翻译： 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

    Methods of Predicting Antibody Solubility
    8.
    发明申请
    Methods of Predicting Antibody Solubility 审中-公开
    预测抗体溶解度的方法

    公开(公告)号：US20110189790A1

    公开(公告)日：2011-08-04

    申请号：US12863489

    申请日：2009-01-20

    申请人： Karyn O'Neil ,  Steven Jacobs ,  Shong-Juin Wu ,  Deldra Bethea ,  Ylqing Feng

    发明人： Karyn O'Neil ,  Steven Jacobs ,  Shong-Juin Wu ,  Deldra Bethea ,  Ylqing Feng

    IPC分类号： G01N30/02

    CPC分类号： G01N33/6854 ,  B01D15/3809

    摘要： The invention provides methods for testing and ranking therapeutic antibody candidates for biophysical properties related to solubility and the susceptibility of the antibody to aggregate in aqueous solutions. The methods are useful for selecting among antibody libraries or variants for candidates which can be formulated at high concentrations.

    摘要翻译： 本发明提供了用于测试和评估与溶解度相关的生物物理性质的治疗性抗体候选物和抗体在水溶液中聚集的易感性的方法。 该方法可用于在可以以高浓度配制的候选物之间选择抗体文库或变体。