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    Medical articles that stimulate endothelial cell migration
    3.
    发明授权
    Medical articles that stimulate endothelial cell migration 失效
    刺激内皮细胞迁移的医学文章

    公开(公告)号：US08118857B2

    公开(公告)日：2012-02-21

    申请号：US11947150

    申请日：2007-11-29

    申请人： Daniel VanCamp ,  Rajesh Radhakrishnan ,  Eric Nielson ,  Verivada Chandrasekaran

    发明人： Daniel VanCamp ,  Rajesh Radhakrishnan ,  Eric Nielson ,  Verivada Chandrasekaran

    IPC分类号： A61F2/82

    CPC分类号： A61N1/326 ,  A61L27/04 ,  A61L27/50 ,  A61L31/022 ,  A61L31/14 ,  A61N1/30

    摘要： A medical article that includes (a) an electronically conductive substrate having a specific conductivity of at least 1 μS/cm and (b) a galvanic couple that includes a first member and a second member arranged in sufficient proximity to each other to generate a localized electric field under physiological conditions. The first and second members are selected such that the galvanic couple exhibits an average plateau current density of at least 25 microamps/cm2 when short circuited in a zero resistance ammeter test at room temperature using a saline electrolyte.

    摘要翻译： 一种医疗制品，其包括（a）具有至少1μS/ cm的比电导率的电子导电基底和（b）包括彼此足够接近地布置的第一构件和第二构件的电偶，以产生局部 生理条件下的电场。 选择第一和第二构件，使得当在室温下使用盐水电解质的零电阻电流表试验中短路时，电偶对的平均平均电流密度至少为25微安/ cm2。

    MEDICAL ARTICLES THAT STIMULATE ENDOTHELIAL CELL MIGRATION
    4.
    发明申请
    MEDICAL ARTICLES THAT STIMULATE ENDOTHELIAL CELL MIGRATION 失效
    刺激内皮细胞迁移的医学文章

    公开(公告)号：US20090143856A1

    公开(公告)日：2009-06-04

    申请号：US11947150

    申请日：2007-11-29

    申请人： Daniel VanCamp ,  Rajesh Radhakrishnan ,  Eric Nielson ,  Verivada Chandrasekaran

    发明人： Daniel VanCamp ,  Rajesh Radhakrishnan ,  Eric Nielson ,  Verivada Chandrasekaran

    IPC分类号： A61F2/82

    CPC分类号： A61N1/326 ,  A61L27/04 ,  A61L27/50 ,  A61L31/022 ,  A61L31/14 ,  A61N1/30

    摘要： A medical article that includes (a) an electronically conductive substrate having a specific conductivity of at least 1 μS/cm and (b) a galvanic couple that includes a first member and a second member arranged in sufficient proximity to each other to generate a localized electric field under physiological conditions. The first and second members are selected such that the galvanic couple exhibits an average plateau current density of at least 25 microamps/cm2 when short circuited in a zero resistance ammeter test at room temperature using a saline electrolyte.

    摘要翻译： 一种医疗制品，其包括（a）具有至少1μS/ cm的比电导率的电子导电基底和（b）包含第一构件和第二构件的电偶，所述第一构件和第二构件布置成彼此足够接近以产生局部 生理条件下的电场。 选择第一和第二构件，使得当在室温下使用盐水电解质的零电阻电流表试验中短路时，电偶对的平均平均电流密度至少为25微安/ cm2。

    Tube feeding apparatus
    6.
    发明授权
    Tube feeding apparatus 失效
    管饲机

    公开(公告)号：US06494353B2

    公开(公告)日：2002-12-17

    申请号：US09991086

    申请日：2001-11-16

    申请人： Derrick S. Small ,  Eric Nielson ,  Arthur E. Givens ,  Sean Peterson ,  Douglas L. Sagarsee

    发明人： Derrick S. Small ,  Eric Nielson ,  Arthur E. Givens ,  Sean Peterson ,  Douglas L. Sagarsee

    IPC分类号： B65H2024

    CPC分类号： B23D36/0058 ,  B21D3/05 ,  Y10T83/145 ,  Y10T83/2192

    摘要： A supply of continuous thin wall tubing which is drawn by a pair of opposed conveyor belts frictionally engaging the outside surfaces of the tubing first through a tube straightening device before the tube walls become engaged with the aforesaid conveyor belts so that straightened tubing is always subjected to engagement with the surfaces on the conveyor belts. The conveyor belts effect a longitudinal driving movement of the tubing into and through a tube cutting device and thence into a tube length control for accurately positioning the tube relative to the tube cutters in the tube cutting device and before the tube is cut. Once the tube length detection circuitry in the tube length control has been satisfied by the positioning of the tubing, the tube cutters in the tube cutting device is activated to sever the tubing.

    摘要翻译： 供应连续的薄壁管道，其被一对相对的输送带牵引，其在管壁与前述传送带接合之前首先通过管矫正装置摩擦地接合管道的外表面，使得矫直管总是经受 与传送带上的表面接合。 传送带影响管道进入管道切割装置并通过管道切割装置的纵向驱动运动，然后进入管子长度控制器，用于相对于管切割装置中的管切割器精确地定位管子，并且在管切割之前。 一旦管长度控制中的管长度检测电路已经通过管的定位得到满足，管切割装置中的管切割器被激活以切断管。

    Internal medical devices containing peroxide-converting catalysts
    7.
    发明申请
    Internal medical devices containing peroxide-converting catalysts 审中-公开
    含有过氧化物转化催化剂的内部医疗器械

    公开(公告)号：US20070154466A1

    公开(公告)日：2007-07-05

    申请号：US11322924

    申请日：2005-12-30

    申请人： Jan Weber ,  Eric Nielson

    发明人： Jan Weber ,  Eric Nielson

    IPC分类号： A61F2/02 ,  A61K38/44 ,  A61K31/727

    CPC分类号： A61L31/082 ,  A61K31/727 ,  A61K38/44 ,  A61L31/128 ,  A61L31/148 ,  C12Y111/01006

    摘要： The present invention is directed to implantable and insertable medical devices (also referred to herein as internal medical devices), which contain one or more peroxide-converting catalysts. According to an aspect of the invention, internal medical devices are provided, which contain (a) a substrate and (b) a peptide-containing, peroxide-converting catalyst disposed over at least a portion of the substrate. According to another aspect of the invention, internal medical devices are provided which contain a catalyst binding entity. The catalyst binding entity is adapted to bind to endogenous peroxide-converting catalyst upon implantation or insertion of the devices into patients. In another aspect of the invention, internal medical devices are provided which contain a biodegradable region that in turn contains a peroxide-converting catalyst. These devices release the catalyst in conjunction with degradation of the biodegradable region. In yet another aspect of the invention, internal medical devices are provided which contain a substrate, a multilayer region disposed over at least a portion of the substrate, and a peroxide-converting catalyst disposed within the multilayer region. The multilayer region, in turn, contains a plurality of charged layers of alternating charge, which charged layers further contain a plurality of polyelectrolyte containing layers.

    摘要翻译： 本发明涉及含有一种或多种过氧化物转化催化剂的可植入和可插入医疗装置（本文也称为内部医疗装置）。 根据本发明的一个方面，提供了内部医疗装置，其包含（a）底物和（b）设置在所述基底的至少一部分上的含肽的过氧化物转化催化剂。 根据本发明的另一方面，提供了含有催化剂结合实体的内部医疗装置。 催化剂结合实体适于在将装置植入或插入患者体内时结合内源性过氧化物转化催化剂。 在本发明的另一方面，提供了含有可生物降解区域的内部医疗装置，其又含有过氧化物转化催化剂。 这些装置与可生物降解区域的降解一起释放催化剂。 在本发明的另一方面，提供了内置医疗装置，其包含基材，设置在基材的至少一部分上的多层区域和设置在多层区域内的过氧化物转化催化剂。 多层区域又包含多个交替电荷的带电层，该带电层还含有多个含聚电解质的层。