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    Substituted pyrimido[1,2-a]azepines useful as HIV integrase inhibitors
    4.
    发明授权
    Substituted pyrimido[1,2-a]azepines useful as HIV integrase inhibitors 有权
    可用作HIV整合酶抑制剂的取代的嘧啶并[1,2-a]吖庚因

    公开(公告)号：US07414045B2

    公开(公告)日：2008-08-19

    申请号：US10540449

    申请日：2003-12-18

    申请人： Benedetta Crescenzi ,  Olaf Kinzel ,  Ester Muraglia ,  Federica Orvieto ,  Giovanna Pescatore ,  Michael Rowley ,  Vincenzo Summa

    发明人： Benedetta Crescenzi ,  Olaf Kinzel ,  Ester Muraglia ,  Federica Orvieto ,  Giovanna Pescatore ,  Michael Rowley ,  Vincenzo Summa

    IPC分类号： A61K31/517 ,  C07D487/04 ,  A61K31/519 ,  C07D239/70

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds of Formula (A): are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein n is an integer equal to zero, 1, 2 or 3, and R1, R3, R4, R12, R14, R16, R30, R32, R34 and R36 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 四氢-4H-吡啶并[1,2-a]嘧啶和式（A）的相关化合物：描述为HIV整合酶和HIV复制抑制剂的抑制剂，其中n是等于0,1,2或3的整数， 和R 1，R 3，R 4，R 12，R 14， ，R 16，R 30，R 32，R 34和R 36， 在本文中定义。 这些化合物可用于预防和治疗艾滋病毒感染以及艾滋病的预防，延迟发作和治疗。 这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

    Tetrahydro--4h-pyrido[1,2-a}pyrimidines and related compounds useful as hiv integrase inhibitors
    6.
    发明申请
    Tetrahydro--4h-pyrido[1,2-a}pyrimidines and related compounds useful as hiv integrase inhibitors 有权
    四氢-4H-吡啶并[1,2-a]嘧啶和有用的化合物可用作hiv整合酶抑制剂

    公开(公告)号：US20060046985A1

    公开(公告)日：2006-03-02

    申请号：US10540449

    申请日：2003-12-18

    申请人： Benedetta Crescenzi ,  Olaf Kinzel ,  Ester Muraglia ,  Federica Orvieto ,  Giovanna Pescatore ,  Michael Rowley ,  Vincenzo Summa

    发明人： Benedetta Crescenzi ,  Olaf Kinzel ,  Ester Muraglia ,  Federica Orvieto ,  Giovanna Pescatore ,  Michael Rowley ,  Vincenzo Summa

    IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/519 ,  C07D487/04

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds of Formula (A): are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein n is an integer equal to zero, 1, 2 or 3, and R1, R3, R4, R12, R14, R16, R30, R32, R34 and R36 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 四氢-4H-吡啶并[1,2-a]嘧啶和式（A）的相关化合物：描述为HIV整合酶和HIV复制抑制剂的抑制剂，其中n是等于0,1,2或3的整数， 和R 1，R 3，R 4，R 12，R 14， ，R 16，R 30，R 32，R 34和R 36， 在本文中定义。 这些化合物可用于预防和治疗艾滋病毒感染以及艾滋病的预防，延迟发作和治疗。 这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

    Tetrahydro-4H-pyrido[1,2-a] pyrimidines useful as HIV integrase inhibitors
    7.
    发明授权
    Tetrahydro-4H-pyrido[1,2-a] pyrimidines useful as HIV integrase inhibitors 有权
    可用作HIV整合酶抑制剂的四氢-4H-吡啶并[1,2-a]嘧啶

    公开(公告)号：US07968553B2

    公开(公告)日：2011-06-28

    申请号：US12075514

    申请日：2008-03-12

    申请人： Benedetta Crescenzi ,  Olaf Kinzel ,  Ester Muraglia ,  Federica Orvieto ,  Giovanna Pescatore ,  Michael Rowley ,  Vincenzo Summa

    发明人： Benedetta Crescenzi ,  Olaf Kinzel ,  Ester Muraglia ,  Federica Orvieto ,  Giovanna Pescatore ,  Michael Rowley ,  Vincenzo Summa

    IPC分类号： A61K31/517 ,  C07D487/04 ,  A61K31/519 ,  C07D239/70

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds of Formula A: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein n is an integer equal to zero, 1, 2 or 3, and R1, R3, R4, R12, R14, R16, R30, R32, R34 and R36 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 四氢-4H-吡啶并[1,2-a]嘧啶和式A的相关化合物被描述为HIV整合酶的抑制剂和HIV复制抑制剂，其中n是等于0,1,2或3的整数，R 1 ，R 3，R 4，R 12，R 14，R 16，R 30，R 32，R 34和R 36如本文所定义。 这些化合物可用于预防和治疗艾滋病毒感染以及艾滋病的预防，延迟发作和治疗。 这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。