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    Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
    4.
    发明授权
    Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection 有权
    用于治疗RNA依赖性RNA病毒感染的核苷芳基氨基磷酸酯

    公开(公告)号：US07879815B2

    公开(公告)日：2011-02-01

    申请号：US12223940

    申请日：2007-02-12

    申请人： Malcolm MacCoss ,  David B. Olsen ,  Monica Donghi ,  Cristina Gardelli ,  Steven Harper ,  Malte Meppen ,  Frank Narjes ,  Barbara Pacini

    发明人： Malcolm MacCoss ,  David B. Olsen ,  Monica Donghi ,  Cristina Gardelli ,  Steven Harper ,  Malte Meppen ,  Frank Narjes ,  Barbara Pacini

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07H19/06

    摘要： The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.

    摘要翻译： 本发明提供结构式（I）的核苷芳基氨基磷酸酯，其是RNA依赖性RNA病毒聚合酶抑制剂的前体。 这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的含有这种核苷芳基氨基磷酸酯的药物组合物。 还公开了本发明的核苷芳基氨基磷酸酯抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

    Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection
    5.
    发明申请
    Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection 审中-公开
    用于治疗Rna依赖性Rna病毒感染的氟化吡咯并[2,3-D]嘧啶核苷

    公开(公告)号：US20080280842A1

    公开(公告)日：2008-11-13

    申请号：US11664564

    申请日：2005-10-17

    申请人： Malcolm MacCoss ,  David B. Olsen ,  Joseph Leone ,  Philippe L. Durette

    发明人： Malcolm MacCoss ,  David B. Olsen ,  Joseph Leone ,  Philippe L. Durette

    IPC分类号： A61K31/7064 ,  C07H19/04 ,  A61P31/12

    CPC分类号： C07H19/14

    摘要： The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such fluorinated pyrrolo[2,3-d]pyrimidine nucleoside alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the fluorinated pyrrolo[2,3-d]pyrimidine nucleoside of the present invention.

    摘要翻译： 本发明提供了作为RNA依赖性RNA病毒聚合酶抑制剂的氟化吡咯并[2,3，d]嘧啶核苷化合物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。 本发明还描述了含有这种氟化吡咯并[2,3-d]嘧啶核苷的药物组合物，或者与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合。 还公开了本发明的氟化吡咯并[2,3-d]嘧啶核苷抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

    DNA polymerase extension assay
    7.
    发明授权
    DNA polymerase extension assay 失效
    DNA聚合酶延伸测定

    公开(公告)号：US6100028A

    公开(公告)日：2000-08-08

    申请号：US973139

    申请日：1998-07-31

    申请人： James L. Cole ,  Lawrence C. Kuo ,  David B. Olsen

    发明人： James L. Cole ,  Lawrence C. Kuo ,  David B. Olsen

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6806

    摘要： The present invention provides rapid accurate sensitive assays specific for the detection of at least one a single stranded oligonucleotide produced by the action of an enzyme on a substrate. The assays are useful to detect the presence in a sample of an enzyme which acts on an oligonucleotide substrate to generate a single stranded oligonucleotide product and to detect inhibitors of such an enzyme.

    摘要翻译： PCT No.PCT / US96 / 08330 Sec。 371日期：1998年7月31日 102（e）1998年7月31日PCT PCT 1996年6月3日PCT公布。 出版物WO96 / 40994 日期1996年12月19日本发明提供了对通过酶在基质上的作用产生的至少一种单链寡核苷酸的检测特异性的快速精确的敏感性测定。 测定法可用于检测在寡核苷酸底物上作用于酶的样品中的存在以产生单链寡核苷酸产物并检测这种酶的抑制剂。