-
公开(公告)号:US20130005592A1
公开(公告)日:2013-01-03
申请号:US13394936
申请日:2010-09-10
申请人: Steven Stone , Alexander Gutin , Darl Flake , Francisco J. Esteva , Dihua Yu
发明人: Steven Stone , Alexander Gutin , Darl Flake , Francisco J. Esteva , Dihua Yu
IPC分类号: C40B30/04 , C12Q1/68 , G01N33/574 , C07H21/04
CPC分类号: C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要: The invention generally relates to molecular diagnostics, and particularly to molecular markers for cancer therapy response and methods of use thereof.
摘要翻译: 本发明一般涉及分子诊断,特别涉及癌症治疗反应的分子标记及其使用方法。
-
公开(公告)号:US20130302242A1
公开(公告)日:2013-11-14
申请号:US13819963
申请日:2011-08-30
申请人: Steven Stone , Alexander Gutin , Susanne Wagner , Julia Reid
发明人: Steven Stone , Alexander Gutin , Susanne Wagner , Julia Reid
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/20
摘要: Biomarkers and methods using the biomarkers for molecular detection and classification of disease and, particularly, molecular markers for cancer diagnosis and prognosis and methods of use thereof are provided.
摘要翻译: 提供了使用生物标志物进行分子检测和分类疾病的生物标志物和方法,特别是用于癌症诊断和预后的分子标志物及其使用方法。
-
公开(公告)号:US20120041274A1
公开(公告)日:2012-02-16
申请号:US13177887
申请日:2011-07-07
申请人: Steven Stone , Alexander Gutin , Susanne Wagner , Julia Reid
发明人: Steven Stone , Alexander Gutin , Susanne Wagner , Julia Reid
CPC分类号: C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G16B20/00 , G16B40/00
摘要: Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.
摘要翻译: 提供了使用生物标志物预测患者癌症复发风险的生物标志物和方法。
-
公开(公告)号:US20120053253A1
公开(公告)日:2012-03-01
申请号:US13178380
申请日:2011-07-07
申请人: Steven Stone , Alexander Gutin , Susanne Wagner , Julia Reid
发明人: Steven Stone , Alexander Gutin , Susanne Wagner , Julia Reid
CPC分类号: C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
摘要: Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.
摘要翻译: 提供了使用生物标志物预测患者癌症复发风险的生物标志物和方法。
-
公开(公告)号:US09605319B2
公开(公告)日:2017-03-28
申请号:US13819963
申请日:2011-08-30
申请人: Steven Stone , Alexander Gutin , Susanne Wagner , Julia Reid
发明人: Steven Stone , Alexander Gutin , Susanne Wagner , Julia Reid
CPC分类号: C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/20
摘要: Biomarkers and methods using the biomarkers for molecular detection and classification of disease and, particularly, molecular markers for cancer diagnosis and prognosis and methods of use thereof are provided.
-
公开(公告)号:US20130143747A1
公开(公告)日:2013-06-06
申请号:US13310916
申请日:2011-12-05
CPC分类号: C12Q1/6886 , C12Q2600/156 , G16H50/20
摘要: Methods and compositions involving molecular markers for the detection and characterization of cancer in a patient are provided.
摘要翻译: 提供了涉及用于患者癌症检测和表征的分子标记物的方法和组合物。
-
公开(公告)号:US07794933B1
公开(公告)日:2010-09-14
申请号:US11326603
申请日:2006-01-04
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要: The invention relate to the discovery of a depression associated AKAP9 predisposing variant. The invention provides for detecting the variant. The invention also provides methods for screening for antidepressants based on modulating AKAP9 mediated signaling.
摘要翻译: 本发明涉及发现抑郁症相关的AKAP9易感性变体。 本发明提供了检测变体。 本发明还提供了基于调节AKAP9介导的信号传导来筛选抗抑郁药的方法。
-
公开(公告)号:US20120015050A1
公开(公告)日:2012-01-19
申请号:US13164499
申请日:2011-06-20
IPC分类号: A61K33/24 , A61K31/28 , A61K31/704 , A61P35/00 , A61K31/166 , A61K31/501 , A61K31/4184 , C12Q1/68 , A61K31/4375
CPC分类号: C12Q1/6886 , C12Q1/6827 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G16B20/00 , C12Q2537/16
摘要: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
摘要翻译: 本文件提供了评估样品(例如癌细胞)中存在杂合性(LOH)特征丧失的方法和材料。 例如,提供了用于确定细胞(例如,癌细胞)是否包含LOH标记的方法和材料。 还提供了用于鉴别具有同源性定向修复(HDR)缺陷的细胞(例如癌细胞)的材料和方法以及用于鉴定可能对特定癌症治疗方案作出反应的癌症患者的材料和方法。
-
公开(公告)号:US20090029362A1
公开(公告)日:2009-01-29
申请号:US11944269
申请日:2007-11-21
申请人: Kirsten Timms , Alexander Gutin , Victor Abkevich , Jerry Lanchbury , Julie A. DeLoia , Alfred Guirguis , Esther Elishaev
发明人: Kirsten Timms , Alexander Gutin , Victor Abkevich , Jerry Lanchbury , Julie A. DeLoia , Alfred Guirguis , Esther Elishaev
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6886 , C12Q2600/112
摘要: The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a common source.
摘要翻译: 本发明涉及拷贝数分布分析。 具体来说,使用拷贝数分布分析来确定单个个体中两个或更多个单独的肿瘤是否源于共同来源。
-
公开(公告)号:US20070082347A1
公开(公告)日:2007-04-12
申请号:US11450909
申请日:2006-06-08
申请人: Jerry Lanchbury , Alexander Gutin , Andrey Zharkikh , Julia Reid , Kirsten Timms , Susanne Wagner , Ann-Marie Woodland
发明人: Jerry Lanchbury , Alexander Gutin , Andrey Zharkikh , Julia Reid , Kirsten Timms , Susanne Wagner , Ann-Marie Woodland
CPC分类号: C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要: Variants in TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 and AMFR genes are disclosed which are useful as biomarkers for predicting the TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 or AMFR gene expression level and the biological functions associated thereof.
摘要翻译: 公开了TLK1,WARS2,ARTS2,MSR,AKAP9,DNAJD1,GOLPH4,RABEP1,TAP2,NARG2,DDX58,CD39,FKBP1a,SRI,XRRA1,IRF5和AMFR基因中的变体,其用作预测TLK1,WARS2, ARTS2,MSR,AKAP9,DNAJD1,GOLPH4,RABEP1,TAP2,NARG2,DDX58,CD39,FKBP1a,SRI,XRRA1,IRF5或AMFR基因表达水平及其相关生物学功能。
-
-
-
-
-
-
-
-
-