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16 条记录 (耗时 0.033 秒)

    Cap with conforming ear band
    1.
    发明申请
    Cap with conforming ear band 审中-公开
    帽子符合耳环

    公开(公告)号：US20070033707A1

    公开(公告)日：2007-02-15

    申请号：US11201471

    申请日：2005-08-11

    申请人： Steven Stone

    发明人： Steven Stone

    IPC分类号： A42B1/06

    CPC分类号： A42B1/066 ,  A42B1/22

    摘要： An improved self adjusting cap for all weather use is disclosed. The improvement lies in the modified attached ear protecting band. The band has an upper edge attached to the crown and a shorter lower edge generally parallel to the upper edge. The lower edge has a shorter linear length than the upper edge so the band more closely conforms to the head of the wearer. Also, the band conforms to the head of the wearer when folded up into the cap without any bunching of material. Additionally, the two forward edges running from the upper edge to the lower edge have an arcuate shape which allows more of the face of the wearer to be protected without obstructing the peripheral vision of the wearer.

    摘要翻译： 公开了一种用于所有天气使用的改进的自调节盖。 改进在于修改的附着耳保护带。 带具有附接到冠部的上边缘和大体平行于上边缘的较短下边缘。 下边缘具有比上边缘更短的线性长度，因此该带更紧密地符合佩戴者的头部。 此外，当折叠到帽子中时，带子符合穿戴者的头部，而没有任何材料的聚束。 此外，从上边缘延伸到下边缘的两个前边缘具有弓形形状，其允许更多的佩戴者的脸部被保护而不会妨碍佩戴者的周边视觉。

    Mouse MTSI gene
    3.
    发明授权
    Mouse MTSI gene 失效
    小鼠MTSI基因

    公开(公告)号：US5843756A

    公开(公告)日：1998-12-01

    申请号：US508735

    申请日：1995-07-28

    申请人： Steven Stone ,  Ping Jiang ,  Alexander Kamb

    发明人： Steven Stone ,  Ping Jiang ,  Alexander Kamb

    IPC分类号： C07H21/04 ,  C12N1/20 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85

    CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The present invention relates to the Multiple Tumor Suppressor (MTS) genes in mice, their expression products, and their homology to the human MTS genes. The human MTS genes are involved in human cancers. The invention is further related to the use of the MTS genes in the therapy, diagnosis and prognosis of human cancer. The invention further relates to mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

    摘要翻译： 本发明涉及小鼠中的多重肿瘤抑制因子（MTS）基因，其表达产物及其与人MTS基因的同源性。 人类MTS基因涉及人类癌症。 本发明进一步涉及MTS基因在人类癌症的治疗，诊断和预后中的应用。 本发明还涉及MTS基因中的突变及其在诊断黑素瘤，白血病，星形细胞瘤，成胶质细胞瘤，淋巴瘤，神经胶质瘤，霍奇金淋巴瘤，CLL和胰腺，乳腺，甲状腺，卵巢，子宫， 睾丸，肾，胃和直肠。 本发明还涉及在MTS基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 最后，本发明涉及用于癌症治疗的药物的筛选。

    Obesity gene and use thereof
    5.
    发明授权
    Obesity gene and use thereof 有权
    肥胖基因及其用途

    公开(公告)号：US08034564B2

    公开(公告)日：2011-10-11

    申请号：US11740378

    申请日：2007-04-26

    申请人： Donna M. Shattuck ,  Steven Stone ,  Deanna L. Russell ,  Victor Abkevich ,  Steven Hunt

    发明人： Donna M. Shattuck ,  Steven Stone ,  Deanna L. Russell ,  Victor Abkevich ,  Steven Hunt

    IPC分类号： C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  G01N2800/044

    摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human obesity and diabetes predisposing gene, specifically the TBC1D1 gene, some mutant alleles of which cause susceptibility to obesity and/or diabetes. More specifically, the invention relates to germline mutations in the TBC1D1 gene and their use in the diagnosis of predisposition to obesity and diabetes. Finally, the invention relates to the screening of the TBC1D1 gene for mutations/alterations, which are useful for diagnosing the predisposition to obesity.

    摘要翻译： 本发明一般涉及人类遗传学领域。 具体而言，本发明涉及用于分离和检测人类肥胖症和糖尿病易感基因，特别是TBC1D1基因的一些突变等位基因导致肥胖和/或糖尿病易感性的方法和材料。 更具体地，本发明涉及TBC1D1基因中的种系突变及其在诊断肥胖和糖尿病易感性中的用途。 最后，本发明涉及用于突变/改变的TBC1D1基因的筛选，其可用于诊断肥胖倾向。

    BI-DIRECTIONAL LED SAFETY WEAR
    6.
    发明申请
    BI-DIRECTIONAL LED SAFETY WEAR 审中-公开
    双向LED安全磨损

    公开(公告)号：US20110235311A1

    公开(公告)日：2011-09-29

    申请号：US12731597

    申请日：2010-03-25

    申请人： Steven STONE

    发明人： Steven STONE

    IPC分类号： F21V21/084 ,  F21V21/08

    CPC分类号： A42B3/044 ,  A41D13/01

    摘要： An apparatus and method of protecting a pedestrian or cyclist from accidental collision with a vehicle wherein a first strip is directly or indirectly mounted on the rear of a user; the first strip including a plurality of light emitting devices that emit red light upon activation by a power means; and a second strip that is directly or indirectly mounted on the front of a user; the second strip including a plurality of light emitting devices that emit white, near white light upon activation by a power means; the first and second strips preferably forming an integral part of a garment worn by the user.

    摘要翻译： 一种保护行人或骑自行车者免受与车辆的意外碰撞的装置和方法，其中第一条直接或间接地安装在用户的后部; 所述第一条带包括多个发光装置，所述多个发光装置在通过动力装置激活时发出红光; 以及直接或间接地安装在使用者的前面上的第二条带; 所述第二条带包括多个发光器件，所述多个发光器件在通过功率器件激活时发出白色近白光; 第一和第二条优选地形成由使用者佩戴的衣服的整体部分。

    Mouse MTS2 gene
    7.
    发明授权
    Mouse MTS2 gene 有权
    小鼠MTS2基因

    公开(公告)号：US06210949B1

    公开(公告)日：2001-04-03

    申请号：US09201139

    申请日：1998-11-30

    申请人： Steven Stone ,  Ping Jiang ,  Alexander Kamb

    发明人： Steven Stone ,  Ping Jiang ,  Alexander Kamb

    IPC分类号： C07H2104

    CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The present invention relates to the Multiple Tumor Suppressor (MTS) genes in mice, their expression products, and their homology to the human MTS genes. The human MTS genes are involved in human cancers. The invention is further related to the use of the MTS genes in the therapy, diagnosis and prognosis of human cancer. The invention further relates to mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

    摘要翻译： 本发明涉及小鼠中的多重肿瘤抑制因子（MTS）基因，其表达产物及其与人MTS基因的同源性。 人类MTS基因涉及人类癌症。 本发明进一步涉及MTS基因在人类癌症的治疗，诊断和预后中的应用。 本发明还涉及MTS基因中的突变及其在诊断黑色素瘤，白血病，星形细胞瘤，成胶质细胞瘤，淋巴瘤，神经胶质瘤，霍奇金淋巴瘤，CLL和胰腺，乳腺，甲状腺，卵巢，子宫， 睾丸，肾，胃和直肠。 本发明还涉及在MTS基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 最后，本发明涉及用于癌症治疗的药物的筛选。

    Method for ligating adaptors to nucleic acids which methods are useful for obtaining the ends of genes
    8.
    发明授权
    Method for ligating adaptors to nucleic acids which methods are useful for obtaining the ends of genes 失效
    将衔接子与核酸连接的方法，该方法可用于获得基因的末端

    公开(公告)号：US5789206A

    公开(公告)日：1998-08-04

    申请号：US499787

    申请日：1995-07-07

    申请人： Sean V. Tavtigian ,  Steven Stone ,  Ping Jiang ,  Alexander Kamb

    发明人： Sean V. Tavtigian ,  Steven Stone ,  Ping Jiang ,  Alexander Kamb

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6853

    摘要： The present invention is directed to cloning the ends of genes. Traditionally it has been very difficult to recover the 5' end of a gene. The present invention greatly eases this problem. The invention is a variation on RACE and uses a combination of techniques. Specific genes are purified by using three enrichment steps--1) a polymerase chain reaction, 2) a hybrid capture step, and 3) a second polymerase chain reaction. The inclusion of the hybrid capture step results in a greater enrichment than occurs with RACE. The ends of the gene are retained by use of a novel technique of attaching adaptors at the ends of the nucleic. The 5' end of the gene is conserved by preparing a first strand of cDNA and ligating to this an adaptor which is partially double stranded wherein the overhang or single stranded region of the adaptor is degenerate which allows for a fraction of the adaptor population to hybridize with the first strand of cDNA at the 3' end of the cDNA. This hybridization holds the adaptor in conjunction with the cDNA during the ligation step thereby resulting in a highly efficient ligation. The unique portion of the adaptor is used to design an oligomer to prime the second strand synthesis. None of the 5' sequence is lost in this method thereby allowing for a greater possibility of recovering the extreme 5' end of the gene.

    摘要翻译： 本发明涉及克隆基因的末端。 传统上，恢复基因的5'末端是非常困难的。 本发明大大减轻了这个问题。 本发明是RACE的变体，并且使用技术的组合。 通过使用三个富集步骤-1）聚合酶链反应，2）杂交捕获步骤和3）第二聚合酶链反应来纯化特异性基因。 包含杂交捕获步骤导致比RACE发生的更大的富集。 通过使用在核酸末端连接衔接子的新技术来保留基因的末端。 基因的5'末端通过制备第一条cDNA链并连接到该部分双链的衔接子来保守，其中衔接子的突出端或单链区域是简并的，其允许一部分衔接子群体杂交 cDNA的第一条cDNA在cDNA的3'末端。 该杂交在连接步骤期间使衔接子与cDNA结合，从而导致高效连接。 适配器的独特部分用于设计低聚物以引发第二链合成。 在该方法中没有一个5'序列丢失，从而允许更大的恢复基因的极端5'末端的可能性。

    Trolling line depressor
    9.
    发明授权
    Trolling line depressor 失效
    拖钓线抑制器

    公开(公告)号：US4951413A

    公开(公告)日：1990-08-28

    申请号：US356242

    申请日：1989-05-24

    申请人： Bruce D. Blevins ,  Steven Stone

    发明人： Bruce D. Blevins ,  Steven Stone

    IPC分类号： A01K91/08

    CPC分类号： A01K91/08

    摘要： A troll line depressor includes a pair of triangular wings with a dihedral angle of about 100 degrees therebetween. A rigid bridle connected between the upper and lower ends of the depressor provides a sliding connection for a ring at the end of a towing line, so that the depressor normally develops hydrodynanmic forces to depress the end of the towing line, but can tilt backward to an inoperative position when a fish strikes, or forward to an inoperative position if the depressor engages river bottom debris.

    摘要翻译： 拖钓线压路器包括一对三角形翼片，其间具有大约100度的二面角。 连接在压降器的上端和下端之间的刚性连杆提供了在牵引线端部的环的滑动连接，使得压力机通常产生流体动力以压下牵引线的端部，但是可以向后倾斜 当鱼罢工时，它处于不能工作的位置，或者如果压力器接触河底碎屑，则转向不工作的位置。